1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jbn.2012.1361" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jbn.2012.1361</a>
Pages
161–171
Issue
1
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer.
Publisher
An entity responsible for making the resource available
Journal of biomedical nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics; Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics; Cell Line; Cell Survival/drug effects; Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics; Drug Carriers/administration & dosage/chemistry; Drug Stability; Endocytosis/drug effects; Gallium/*administration & dosage/chemistry/pharmacokinetics; Hemolysis/drug effects; Humans; Lung Neoplasms/*drug therapy/metabolism; Materials Testing; Membrane Potential; Mitochondrial/drug effects; Nanoparticles/*administration & dosage/chemistry; Particle Size; Platelet Aggregation/drug effects; Reactive Oxygen Species/metabolism; Transferrin/chemistry/pharmacology; Tumor
Creator
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Wehrung Daniel; Oyewumi Moses O
Description
An account of the resource
The widespread application of gallium (Ga) in cancer therapy has been greatly hampered by lack of specificity resulting in poor tumor accumulation and retention. To address the challenge, two lipophilic gallium (III) compounds (gallium hexanedione; GaH and gallium acetylacetonate; GaAcAc) were synthesized and antitumor studies were conducted in human lung adenocarcinoma (A549) cells. Nanoparticles (NPs) containing various concentrations of the Ga compounds were prepared using a binary mixture of Gelucire 44/14 and cetyl alcohol as matrix materials. NPs were characterized based on size, morphology, stability and biocompatibility. Antitumor effects of free or NP-loaded Ga compounds were investigated based on cell viability, production of reactive oxygen species and reduction of mitochondrial potential. Compared to free Ga compounds, cytotoxicity of NP-loaded Ga (5-150 microg/ml) was less dependent on concentration and incubation time (exposure) with A549 cells. NP-mediated delivery (5-150 microg Ga/ml) enhanced antitumor effects of Ga compounds and the effect was pronounced at: (i) shorter incubation times; and (ii) at low concentrations of gallium (approximately 50 microg/ml) (p \textless 0.0006). Additional studies showed that
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1166/jbn.2012.1361" target="_blank" rel="noreferrer noopener">10.1166/jbn.2012.1361</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics
Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics
Cell Line
Cell Survival/drug effects
Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics
Department of Pharmaceutical Sciences
Drug Carriers/administration & dosage/chemistry
Drug Stability
Endocytosis/drug effects
Gallium/*administration & dosage/chemistry/pharmacokinetics
Hemolysis/drug effects
Humans
Journal of biomedical nanotechnology
Lung Neoplasms/*drug therapy/metabolism
Materials Testing
Membrane Potential
Mitochondrial/drug effects
Nanoparticles/*administration & dosage/chemistry
NEOMED College of Pharmacy
Oyewumi Moses O
Particle Size
Platelet Aggregation/drug effects
Reactive Oxygen Species/metabolism
Transferrin/chemistry/pharmacology
Tumor
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jps.23510" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jps.23510</a>
Pages
1650–1660
Issue
5
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.
Publisher
An entity responsible for making the resource available
Journal of pharmaceutical sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
Alanine Transaminase/blood; Animals; Biocompatible Materials/chemistry/*metabolism/*toxicity; Cell Line; Creatine/blood; Cytokines/analysis; Erythrocytes/drug effects; Hemolysis/drug effects; Inbred BALB C; Kidney/drug effects/pathology; Light; Liver/drug effects/pathology; Macrophages/cytology/drug effects; Mice; Polycarboxylate Cement/chemistry/*metabolism/*toxicity; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Wehrung Daniel; Sun Shuangyi; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O
Description
An account of the resource
Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p \textgreater 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jps.23510" target="_blank" rel="noreferrer noopener">10.1002/jps.23510</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Alanine Transaminase/blood
Animals
Biocompatible Materials/chemistry/*metabolism/*toxicity
Cell Line
Chamsaz Elaheh A
Creatine/blood
Cytokines/analysis
Department of Pharmaceutical Sciences
Erythrocytes/drug effects
Hemolysis/drug effects
Inbred BALB C
Journal of pharmaceutical sciences
Joy Abraham
Kidney/drug effects/pathology
Light
Liver/drug effects/pathology
Macrophages/cytology/drug effects
Mice
NEOMED College of Pharmacy
Oyewumi Moses O
Polycarboxylate Cement/chemistry/*metabolism/*toxicity
Rats
Sprague-Dawley
Sun Shuangyi
Wehrung Daniel