1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/hep.32027" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.32027</a> ISSN 1527-3350 0270-9139 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/hep.32027" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/hep.32027</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number July 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Integrative Medical Sciences Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource On the mechanisms of biliary flux. Publisher An entity responsible for making the resource available Hepatology Date A point or period of time associated with an event in the lifecycle of the resource 2021 2021-06-23 Creator An entity primarily responsible for making the resource Vartak N; Drasdo D; Geisler F; Itoh T; Oude Elferink RPJ; van de Graaf SFJ; Chiang J; Keitel Verena; Trauner M; Jansen P; Hengstler JG Description An account of the resource Since the late 1950s transport of bile in the liver has been described by the 'osmotic concept', according to which bile flows into the canaliculi towards the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process. Still, 'osmotic canalicular flow' was a sufficient and plausible explanation for the clearance characteristics of a wide variety of choleretic compounds excreted in bile. Imaging techniques have now been established that allow direct flux analysis in bile canaliculi of the intact liver in living organisms. In contrast to the prevailing osmotic concept these analyses strongly suggest that the transport of small molecules in canalicular bile is diffusion dominated, while canalicular flow is negligibly small. In contrast, with the same experimental approach it could be shown that in the interlobular ducts, diffusion is augmented by flow. Thus, bile canaliculi can be compared to a standing water zone that is connected to a river. The seemingly subtle difference between diffusion and flow is of relevance for therapy of a wide range of liver diseases including cholestasis and NAFLD. Here, we incorporated the latest findings on canalicular solute transport, and align them with extant knowledge to present an integrated and explanatory framework of bile flux that will undoubtedly be refined further in the future. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/hep.32027" target="_blank" rel="noreferrer noopener">10.1002/hep.32027</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2021 Chiang J Department of Integrative Medical Sciences Distinguished University Professor Drasdo D Geisler F Hengstler JG Hepatology Itoh T Jansen P journalArticle July 2021 List Keitel Verena NEOMED College of Medicine Oude Elferink RPJ Trauner M van de Graaf SFJ Vartak N