Browse Items (10 total)
- Tags: Hep G2 Cells
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells.
Tags: *Phytotherapy, *Ribes/chemistry, 2010, Antineoplastic Agents, Antioxidants/*therapeutic use, Bhatia Deepak, Bishayee Anupam, Carcinoma, Cell Proliferation/drug effects, Darvesh Altaf S, Department of Pharmaceutical Sciences, Drug Evaluation, Fruit/chemistry, Haznagy-Radnai Erzsebet, Hep G2 Cells, Hepatocellular/*prevention & control, Hohmann Judit, Humans, Liver Neoplasms/*prevention & control, Mbimba Thomas, Morazzoni Paolo, Natural product communications, NEOMED College of Pharmacy, Phytogenic/analysis, Plant Extracts/pharmacology/therapeutic use, Preclinical, Sipos Peter
Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.
Tags: 2013, Aerial, Antineoplastic Agents, Bishayee Anupam, Carcinoma, Desert Climate, Dose-Response Relationship, Drug, Harlev Eli, Hep G2 Cells, Hepatocellular/*drug therapy/pathology, Humans, Inhibitory Concentration 50, Liver Neoplasms/*drug therapy/pathology, Mandal Animesh, Medicinal/chemistry, Nevo Eviatar, Pharmaceutical biology, Phytogenic/administration & dosage/*pharmacology, Plant Components, Plant Extracts/administration & dosage/*pharmacology, Plants, Tetrazolium Salts/chemistry, Thiazoles/chemistry, Thoppil Roslin J, Time Factors
Tags: *Gene Transfer Techniques, 2016, Animals, Cationic lipids, Cell Line, Cell Survival/drug effects/physiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/*administration & dosage/chemistry, gene therapy, Hep G2 Cells, Humans, macrophage activation, Macrophages/drug effects/physiology, Mice, Nanoparticles, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical development and technology, Polyethylene Glycols/*administration & dosage/chemistry, Sadana Prabodh, Transfection, Wehrung Daniel
Tags: 2010, Calcitriol/*metabolism, Calcitriol/pharmacology, Cell Membrane/drug effects/metabolism, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzyme Activation/drug effects, Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors, Genetic/genetics, Han Shuxin, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*drug effects/enzymology/*metabolism, Humans, Intracellular Space/drug effects/metabolism, Li Tiangang, Ligands, Lithocholic Acid/*pharmacology, Mitogen-Activated Protein Kinase Kinases/metabolism, Molecular endocrinology (Baltimore, Md.), NEOMED College of Medicine, Phosphorylation/drug effects, Phosphotyrosine/metabolism, Promoter Regions, Protein Kinase Inhibitors/pharmacology, Protein Transport/drug effects, Proto-Oncogene Proteins c-raf/metabolism, Receptors, Retinoid X Receptor alpha/metabolism, Signal Transduction/*drug effects, src-Family Kinases/metabolism, Steroid Hydroxylases/genetics/metabolism, Strom Stephen, Vitamin D3 24-Hydroxylase
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Tags: 2010, 3' Untranslated Regions/genetics, Base Sequence, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic/drug effects/*genetics, Fibroblast Growth Factors/pharmacology, Gene Expression Regulation, Genetic/drug effects/genetics, Hep G2 Cells, Hepatocytes/drug effects/enzymology/*metabolism, Humans, Isoxazoles/pharmacology, Journal of lipid research, Li Tiangang, MicroRNAs/*genetics/*metabolism, NEOMED College of Medicine, Oligonucleotide Array Sequence Analysis, Owsley Erika, Post-Transcriptional/drug effects/genetics, RNA Processing, Song Kwang-Hoon, Transcription
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.
Tags: 2013, Animals, Bile Acids and Salts/*biosynthesis, Chiang John Y L, Cholesterol, Cholesterol/*biosynthesis/genetics, Circadian Rhythm/*physiology, Department of Integrative Medical Sciences, Diabetes, Diabetes Mellitus, Enzyme Induction/physiology, Fasting/*metabolism, Fatty Liver/drug therapy/genetics/metabolism/pathology, Group F, Hep G2 Cells, Humans, Li Tiangang, Lipid Metabolism, Member 1/genetics/*metabolism, Mice, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Nuclear Receptor Subfamily 1, Nuclear Receptors, Obesity, Pathak Preeti, Phosphorylation/physiology, Protein Kinases/genetics/metabolism, Response Elements/physiology, Steroid 12-alpha-Hydroxylase/*biosynthesis/genetics, The Journal of biological chemistry, Type 2/drug therapy/genetics/metabolism/pathology
Tags: 2015, Animals, Apolipoproteins E/genetics, Atherosclerosis/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Experimental/genetics/metabolism, Hep G2 Cells, Hepatocyte Nuclear Factor 4/*genetics/metabolism, Humans, Knockout, LDL/genetics, Li Yuanyuan, Lipid Metabolism/*genetics, Lipoproteins/metabolism, Liver/metabolism, Mice, MicroRNAs/*genetics/metabolism, Middle Aged, Nature communications, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease/*genetics/metabolism, Physiological/*genetics, Receptors, Stress, Triglycerides/*metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao