Browse Items (9 total)
- Tags: Hepatocyte Nuclear Factor 4
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7 alpha-hydroxylase gene (CYP7A1)
Tags: 2000, BILE acids, bile-acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, chicken ovalbumin, cholesterol metabolism, dna-binding, Hepatocyte Nuclear Factor 4, hormone-receptor superfamily, Journal Article, Journal of lipid research, messenger-rna, orphan receptors, promoter, Receptors, Response Elements, retinoic acid, Stroup D, thyroid-hormone, transcriptional regulation, upstream promoter transcription factor II
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.
Tags: *DNA-Binding Proteins, 2002, alpha-Fetoproteins/genetics/*physiology, Animals, Base Sequence, Bile Acids and Salts/*pharmacology, Biochimica et biophysica acta, Cattle, Chiang John Y L, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, DNA, Eggertsen Gosta, Enzymologic/*drug effects/physiology, Gene Expression Regulation, Genetic, Genetic/*drug effects, Hepatocyte Nuclear Factor 4, Messenger/genetics, NEOMED College of Medicine, Phosphoproteins/genetics/*physiology, Promoter Regions, Rats, RNA, Sprague-Dawley, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, Transcription, Transcription Factors/genetics/*physiology, Yang Yizeng, Zhang Ming
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Tags: *Receptors, *Transcription, 2000, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Cultured, Department of Integrative Medical Sciences, DNA Primers, DNA-Binding Proteins/*metabolism, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Luciferases/genetics, Mutation, NEOMED College of Medicine, Phosphoproteins/*metabolism, Promoter Regions, Rats, Recombinant Proteins/metabolism, Reporter, Sprague-Dawley, Steroid, Stroup D, Transcription Factors/*metabolism, Tumor Cells
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Cell Line, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Chromosome Mapping, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Inhibitors/pharmacology, Gene Expression Regulation/*drug effects, Genetic/drug effects, Genetic/physiology, Hepatocyte Nuclear Factor 4, Hepatocytes/metabolism, Humans, Interleukin-1/*pharmacology, Jahan Asmeen, MAP Kinase Signaling System/drug effects/physiology, Messenger/antagonists & inhibitors, Mitogen-Activated Protein Kinase 8/metabolism, Mitogen-Activated Protein Kinases/antagonists & inhibitors, NEOMED College of Medicine, Phosphoproteins/genetics/metabolism, Phosphorylation, Promoter Regions, Response Elements/genetics, RNA, Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics, Transcription, Transcription Factors/genetics/metabolism
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M