1
40
2
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Text
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<a href="http://doi.org/10.1152/jappl.1990.69.2.694" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1990.69.2.694</a>
Pages
694–699
Issue
2
Volume
69
Dublin Core
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Title
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Administration of a synthetic antiprotease reduces smoke-induced lung injury.
Publisher
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Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
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*Lung Injury; alpha-Macroglobulins/physiology; Animals; Endopeptidases/physiology; Female; Gabexate; Guanidines/*pharmacology; Neutrophils/physiology; Pulmonary Edema/etiology/prevention & control; Pulmonary Gas Exchange/drug effects; Serine Proteinase Inhibitors/*pharmacology; Sheep; Smoke Inhalation Injury/*drug therapy/etiology/physiopathology
Creator
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Niehaus G D; Kimura R; Traber L D; Herndon D N; Flynn J T; Traber D L
Description
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Our previous studies suggest that a neutrophil-mediated inflammatory injury causes a major fraction of the pulmonary edema that occurs after smoke inhalation. Because activated neutrophils extrude cytotoxic proteases, the current study was conducted to evaluate the role of proteases in the pulmonary microvascular injury. Twelve sheep, instrumented for collection of lung lymph, were insufflated with cotton smoke. The sheep were treated 30 min after smoke inhalation with either gabexate mesilate (an inhibitor of serine proteases) or vehicle. Smoke inhalation resulted in an increased protease activity in the lung interstitium, as evidenced by decreases in both antiprotease activity and immunoreactive alpha 2-macroglobulin. Intravenous infusion of gabexate mesilate prevented the decrease in antiprotease activity. The protease inhibitor significantly attenuated the smoke-induced increase in transvascular fluid and protein flux, with untreated animals exhibiting 460% increases in flux compared with 180% in the inhibitor treated sheep. The protease inhibitor also eliminated the functional degradation in gas exchange that was observed in the untreated sheep. These studies strongly suggest that an increase in pulmonary proteolytic enzyme activity is responsible for a significant fraction of the degradation in microvascular integrity and gas exchange that is associated with smoke inhalation injury.
Identifier
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<a href="http://doi.org/10.1152/jappl.1990.69.2.694" target="_blank" rel="noreferrer noopener">10.1152/jappl.1990.69.2.694</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lung Injury
1990
alpha-Macroglobulins/physiology
Animals
Department of Integrative Medical Sciences
Endopeptidases/physiology
Female
Flynn J T
Gabexate
Guanidines/*pharmacology
Herndon D N
Journal of applied physiology (Bethesda, Md. : 1985)
Kimura R
NEOMED College of Medicine
Neutrophils/physiology
Niehaus G D
Pulmonary Edema/etiology/prevention & control
Pulmonary Gas Exchange/drug effects
Serine Proteinase Inhibitors/*pharmacology
Sheep
Smoke Inhalation Injury/*drug therapy/etiology/physiopathology
Traber D L
Traber L D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
208-215
Issue
2
Volume
104
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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THE EFFECT OF LEUKOCYTE DEPLETION ON SMOKE INHALATION INJURY IN SHEEP
Publisher
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Surgery
Date
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1988
1988-08
Subject
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Surgery
Creator
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Basadre J O; Sugi K; Traber D L; Traber L D; Niehaus G D; Herndon D N
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
1988
Basadre J O
Herndon D N
Journal Article or Conference Abstract Publication
Niehaus G D
Sugi K
Surgery
Traber D L
Traber L D