Findings From A Mineral Density Perimenopausal 10-year Follow-up Of Bone In Competitive Runners
bone mineral density; exercise; follow-up studies; hip; Obstetrics & Gynecology; osteoporosis prevention; perimenopause; postmenopausal women; running; spine
Fanning J; Larrick L; Weinstein L; Horrigan T J; Marcotte M P; Flora R F
Journal of Reproductive Medicine
2007
2007-10
Journal Article or Conference Abstract Publication
n/a
Body Size And Leaping Kinematics In Malagasy Vertical Clingers And Leapers
Anthropology; body size; Evolutionary Biology; hip; hypothesis; indriids; kinematics; leaping; lemurs; locomotion; madagascar; morphometrics; orientation; prosimian primates; similarity; vertebrates
Demes B; Jungers W L; Fleagle J G; Wunderlich R E; Richmond B G; Lemelin P
Journal of Human Evolution
1996
1996-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1006/jhev.1996.0066" target="_blank" rel="noreferrer noopener">10.1006/jhev.1996.0066</a>
The Orthopaedic Manifestations of Pseudoachondroplasia
Achondroplasia; Apoptosis; Arthritis; Biomechanics; Bone (axial); Bone dysplasia; Bones; Cartilage; Cartilage (articular); Cartilage oligomeric matrix protein; Chondrocytes; Chromosome 19; Chromosomes; Dwarfism; Dysplasia; Elbow; Elbow (anatomy); Epiphysis; Extremities; Feet; Gait; Hand (anatomy); Hip; Intelligence; Joint diseases; Knee (anatomy); Kyphosis; Medical Sciences--Pediatrics; Mutation; Orthopedics; Plates (structural members); Proteins; Radiographs; Radiography; Skeleton; Thorax; Vertebra; Vertebrae
October 2019 Update
In 1959, Maroteaux and Lamy initially designated pseudoachondroplasia as a distinct dysplasia different from achondroplasia, which is the most common form of skeletal dysplasia associated with dwarfism. Pseudoachondroplasia is the second-most common form of skeletal dysplasia. Pseudoachondroplasia is caused by a mutation in the COMP gene on chromosome 19p13.1-p12 encoding the cartilage oligomeric matrix protein. The mutation causes an accumulation of mutated COMP protein within the rough endoplastic reticulum of chondrocytes leading to premature chondrocyte apoptosis. This cascade of molecular events eventually results in rendering the articular cartilage and growth plate cartilage incapable of withstanding routine biomechanical loads with resultant deformity of the joints, particularly in the lower extremities. A unique opportunity to review charts and radiographs of 141 patients with pseudoachondroplasia allowed the author to assemble the typical findings in pseudoachondroplasia. This cohort, to our knowledge, represents the largest group of patients describing the typical orthopaedic manifestations of pseudoachondroplasia. The intensive review of this cohort yielded the following clinical and radiographic information: Patients with pseudoachondroplasia have a normal craniofacial appearance and are of normal intelligence. Short stature is not present at birth and generally appears by 2 to 4 years of age. The condition is a form of spondyloepiphyseal dysplasia and the long bones are characterized by dysplastic changes in the epiphysis, metaphysis, and vertebral bodies. The hands have short, stubby fingers, short metacarpals, lax wrists, diminished extension of the elbow, and limitation of shoulder motion. Occasionally odontoid dysplasia is seen with kyphosis, scoliosis, and lumbar lordosis, commonly. The gait is characterized by "waddling". The knees show either genu valgum, genu varum, or "windswept" deformity and the feet and ankles are in pronovalgus position with short, wide feet. Radiographically the long bones have altered appearance and structure of the epiphyses with small irregularly formed or fragmented epiphyses or flattening. The metaphyseal regions of the long bones show flaring, widening, or "trumpeting". The cervical vertebrae show platyspondyly. The thoracic and lumbar vertebrae show either platyspondyly, ovoid, "cod-fish" deformity, or anterior "beaking". Most commonly these distortions of the long bones and the axial skeleton, lead to premature arthritis particularly of the hips and often the knees not uncommonly in the 20- to 30-year-old age group. Vertebral "beaking" (Image 1) Epimetaphyseal dysplasia (Image 2)
Guirguis James; Weiner Dennis S
Pediatrics; Evanston
2019
2019-08
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1542/peds.144.2_MeetingAbstract.755" target="_blank" rel="noreferrer noopener">10.1542/peds.144.2_MeetingAbstract.755</a>
Q & A. Hyperostosis associated with hip surgery?
Syndrome; Hip; Arthroplasty; Replacement; Hyperostosis
Rothschild B M
Journal of Musculoskeletal Medicine
2004
2004-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Trochanteric area pain, the result of a quartet of bursal inflammation.
Bursa; Bursitis; Corticosteroids; Dexamethasone; Hip; Injection; Triamcinolone; Trochanter
Bursitis is quite responsive to therapeutic intervention, once the afflicted area is accurately identified. This is especially notable for some hip complaints. Patients' use of the term "hip" can relate to anything from the low back to groin to lateral thigh pain. Trochanteric area surface localization of "hip" pain may afford an opportunity for immediate cure. Effectiveness of therapeutic intervention is predicated upon injection of not one or two, but all four peri-trochanteric bursa with a depot (minimally water-soluble) corticosteroid. The term trochanteric bursitis suggests that the inflammation is more focal than what is clinically observed. While easier to express, perhaps it is time to refer to inflammation in this area, naming all four affected bursae.
Rothschild Bruce
World journal of orthopedics
2013
2013-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.5312/wjo.v4.i3.100" target="_blank" rel="noreferrer noopener">10.5312/wjo.v4.i3.100</a>
Impact of Tranexamic Acid in Total Knee and Total Hip Replacement.
Aged; Antifibrinolytic Agents/adverse effects/therapeutic use; Arthroplasty; Blood Transfusion; Blood Transfusion/statistics & numerical data; Case-Control Studies; Descriptive Statistics; Female; Hemoglobins – Analysis; Hemoglobins/metabolism; Hip; Hip/*methods; Human; Humans; Knee; Knee/*methods; Length of Stay – Evaluation; Length of Stay/statistics & numerical data; Male; Outcome Assessment; Replacement; Retrospective Design; Retrospective Studies; total hip replacement; total knee replacement; tranexamic acid; Tranexamic Acid – Administration and Dosage; Tranexamic Acid/adverse effects/*therapeutic use; Venous Thromboembolism – Risk Factors; Venous Thromboembolism/epidemiology
OBJECTIVE: To evaluate the net clinical benefit of tranexamic acid use in patients undergoing total knee or total hip replacement. METHODS: This is a retrospective study of patients undergoing total knee or total hip replacement. The primary outcome was the net clinical benefit of tranexamic acid use. Secondary outcomes included length of stay, incidence of venous thromboembolism, change in hemoglobin, and number of units of blood transfused. RESULTS: Four hundred and six patients were screened for inclusion and 327 patients met inclusion criteria; 174 patients received tranexamic acid versus 153 patients who received usual care. Tranexamic acid demonstrated a positive net clinical benefit versus usual care (40.8% vs 13.7%, P \textless .01) but did not affect length of stay (3.39 vs 3.37 days, respectively, P = .76). Venous thromboembolism was comparable between groups (2.3% vs 0.7%, P = .38). Average change in hemoglobin and need for transfusion were lower in the treatment group versus the usual care group, respectively (3.46 vs 4.26 mg/dL, P \textless .01). CONCLUSION: Tranexamic acid demonstrated a significant benefit in decreasing change in hemoglobin as well as the need for blood transfusion with no increase in the risk of venous thromboembolism in patients undergoing total knee or total hip replacement.
Boyle Jaclyn A; Soric Mate M
Journal of pharmacy practice
2017
2017-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1177/0897190015621813" target="_blank" rel="noreferrer noopener">10.1177/0897190015621813</a>
Melanotic schwannoma. An unusual case of an ossified soft tissue mass.
Adult; Biopsy; Chronic Disease; Diagnosis; Differential; Female; Heterotopic/*diagnosis/pathology/surgery; Hip; Humans; Immunohistochemistry; Muscle Neoplasms/*diagnosis/pathology/surgery; Myositis Ossificans/diagnosis; Neurilemmoma/*diagnosis/pathology/surgery; Ossification; Soft Tissue Neoplasms/*diagnosis/pathology/surgery
A case of a melanotic schwannoma presenting as a soft tissue mass of the abductors of the hip is reported. The radiographic findings suggested myositis ossificans, but several subtle findings raised the concern for something else. A bilobed appearance, lack of classic zoning pattern of the ossification, and atypical pain pattern should alert the physician. Biopsy should be considered if the radiographic and clinical presentations are not classic for myositis ossificans.
Junko J T; Agamanolis D; Weiner S D
Clinical orthopaedics and related research
1999
1999-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1097/00003086-199912000-00031" target="_blank" rel="noreferrer noopener">10.1097/00003086-199912000-00031</a>
Circadian rhythms in liver metabolism and disease.
ARC; arcuate nucleus; BMAL1; brain and muscle ARNT-like 1; CAR; cholesterol 7alpha-hydroxylase; circadian locomotor output cycles kaput; Circadian rhythm; CLOCK; constitutive androstane receptor; CRY; cryptochrome; CYP7A1; CYPs; cytochrome P450 enzymes; D-site binding protein; DBP; E-box; emergency medical technician; EMT; enhance box; FAA; familial advanced sleep-phase syndrome; farnesoid-X receptor; FASPS; FEO; food anticipatory activity; food entrainable oscillator; forkhead box O3; FOXO3; FXR; G protein-coupled bile acid receptor; glucose transporter 2; GLUT2; HDAC3; hepatic leukemia factor; HIP; histone deacetylase 3; HLF; hypoxia inducing protein; LDL; Liver; liver receptor homolog 1; low-density lipoprotein; LRH1; Metabolic syndrome; NAD+; nicotinamide adenine dinucleotide; PER; period; retinohypothalamic tract; retinoid-related orphan receptor alpha; RHT; ROR-response element; RORalpha; RORE; SCN; SHP; SIRT1; sirtuin 1; small heterodimer partner; suprachiasmatic nucleus; TEF; TGR5; thyrotroph embryonic factor; transcriptional translational feedback loop; TTFL; Type 2 diabetes
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.
Ferrell Jessica M; Chiang John Y L
Acta pharmaceutica Sinica. B
2015
2015-03
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.apsb.2015.01.003" target="_blank" rel="noreferrer noopener">10.1016/j.apsb.2015.01.003</a>