1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(87)90052-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(87)90052-9</a>
Pages
663–672
Issue
6
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-12
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Kinetics; In Vitro Techniques; Hippocampus/*drug effects/physiology; Evoked Potentials/drug effects; Dronabinol/*pharmacology; Pyramidal Tracts/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Nowicky A V; Teyler T J; Vardaris R M
Description
An account of the resource
The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses tested: 10 picomolar (pM), 100 pM, and 1000 pM, resulted in a biphasic change in population spike amplitude, such that 10 pM resulted in an increase, while 100 and 1000 pM resulted in dose-related decreases as compared to the control treatment. Upon subsequent induction of LTP by tetanizing stimulation, the THC treatments resulted in significant changes in the duration but not magnitude of potentiation. The early component of potentiation, post-tetanic potentiation, or PTP, was not affected by the THC treatments. LTP was seen to decay in an exponential manner over the 121 mini post-tetanus monitoring period. For comparisons of LTP duration, therefore, the half-life (t1/2) of LTP was extrapolated from linear regression analysis. The t1/2 values were determined for each treatment group from the slopes of the linear regression analysis of the logarithmically transformed time course data. While the control group t1/2 was determined as 280 min, the t1/2 for the THC groups were: 350 min (10 pM); 91 min (100 pM); and 33 min (1000 pM) doses, respectively. In context with previous reports of the disruptive action of marihuana intoxication on learning and memory, these results suggest that one possible action of THC may be in modulating hippocampal electrophysiology and its role in short-term memory processes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(87)90052-9" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(87)90052-9</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
Animals
Brain research bulletin
Dronabinol/*pharmacology
Evoked Potentials/drug effects
Hippocampus/*drug effects/physiology
In Vitro Techniques
Kinetics
Male
Nowicky A V
Pyramidal Tracts/drug effects/physiology
Rats
Teyler T J
Time Factors
Vardaris R M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0361-9230(96)00268-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0361-9230(96)00268-7</a>
Pages
297–302
Issue
4
Volume
42
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1905-06
Subject
The topic of the resource
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology; Animals; Anticonvulsants/*pharmacology; Electrophysiology; gamma-Aminobutyric Acid/*pharmacology; Hippocampus/*drug effects/physiology; Inbred Strains; Male; N-Methylaspartate/*pharmacology; Phenobarbital/pharmacology; Phenytoin/pharmacology; Rats; Valproic Acid/pharmacology
Creator
An entity primarily responsible for making the resource
Ko G Y; Brown-Croyts L M; Teyler T J
Description
An account of the resource
The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope of the AMPA-EPSP by 13.4% and facilitated the GABA-IPSP slope by 77.12%. Phenytoin (0.02 mg/ml) had no effects on the NMDA-EPSP, AMPA-EPSP, or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0361-9230(96)00268-7" target="_blank" rel="noreferrer noopener">10.1016/s0361-9230(96)00268-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology
Animals
Anticonvulsants/*pharmacology
Brain research bulletin
Brown-Croyts L M
Electrophysiology
gamma-Aminobutyric Acid/*pharmacology
Hippocampus/*drug effects/physiology
Inbred Strains
Ko G Y
Male
N-Methylaspartate/*pharmacology
Phenobarbital/pharmacology
Phenytoin/pharmacology
Rats
Teyler T J
Valproic Acid/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(95)00187-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(95)00187-5</a>
Pages
117–119
Issue
1
Volume
92
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
*Prenatal Exposure Delayed Effects; Animals; Cocaine/*administration & dosage/pharmacology; Electrophysiology; Female; Hippocampus/*drug effects/physiology; In Vitro Techniques; Long-Term Potentiation/*drug effects; Narcotics/*administration & dosage/pharmacology; Neuronal Plasticity/drug effects; Pregnancy; Rabbits; Reference Values; Synapses/drug effects
Creator
An entity primarily responsible for making the resource
Little J Z; Teyler T J
Description
An account of the resource
Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of gestational cocaine exposure on substrates of learning and memory. Rabbits, 30 to 40 days old, were examined for alterations in synaptic plasticity using an intact hippocampal slice preparation. Extracellular recordings revealed in utero cocaine exposure predisposed slices to larger long-term potentiation compared to controls.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(95)00187-5" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(95)00187-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prenatal Exposure Delayed Effects
1996
Animals
Brain research. Developmental brain research
Cocaine/*administration & dosage/pharmacology
Electrophysiology
Female
Hippocampus/*drug effects/physiology
In Vitro Techniques
Little J Z
Long-Term Potentiation/*drug effects
Narcotics/*administration & dosage/pharmacology
Neuronal Plasticity/drug effects
Pregnancy
Rabbits
Reference Values
Synapses/drug effects
Teyler T J