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Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus.

1. Activation of GABAA receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We…

N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can…

Tags: 1992, 2-Amino-5-phosphonovalerate/*pharmacology, Animals, Electron, Evoked Potentials/drug effects, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Microscopy, N-Methyl-D-Aspartate/*physiology, N-Methylaspartate/*pharmacology, Neuroscience, Pyramidal Tracts/drug effects/*physiology, Rats, Receptors, Teyler T J, Time Factors

Two components of long-term potentiation induced by different patterns of afferent activation.

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Afferent Pathways/physiology, Animals, Calcium/*physiology, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Membrane Potentials, Memory/*physiology, N-Methyl-D-Aspartate/*physiology, Nature, Neuronal Plasticity, Receptors, Synaptic Transmission, Teyler T J, Time Factors

Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.

1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current…

Depotentiation of vdccLTP requires NMDAR activation.

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same…

Comparative aspects of hippocampal and neocortical long-term potentiation.

Long-term potentiation (LTP) is a candidate for the synaptic alternations underlying memory storage in the mammalian CNS. In this chapter LTP in hippocampus and in visual neocortex are compared. Comparisons of the optimal tetanus parameters revealed…

Tags: 1989, Action Potentials, Animals, Electric Stimulation, Evoked Potentials, Hippocampus/*physiology, Journal of neuroscience methods, Memory/physiology, N-Methyl-D-Aspartate, Neurotransmitter/*physiology, Receptors, Teyler T J, Visual Cortex/*physiology

Synaptic plasticity in the hippocampal slice: functional consequences.

There are 3 known forms of synaptic plasticity at CNS synapses: long-term potentiation (LTP) mediated by NMDA receptor activation, LTP mediated by voltage-dependent calcium channel (VDCC) activation, and long-term depression (LTD) mediated by the…

Tags: 1995, Animals, Calcium Channels/physiology, Cavus I, Coussens C, Hippocampus/*physiology, Journal of neuroscience methods, Long-Term Potentiation/physiology, Models, N-Methyl-D-Aspartate/physiology, Neurological, Neuronal Plasticity/*physiology, Receptors, Synapses/*physiology, Teyler T J

The development of long-term potentiation in hippocampus and neocortex.

The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5,…

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