1
40
8
-
Text
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<a href="http://doi.org/10.1177/40.2.1552171" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/40.2.1552171</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
293-307
Issue
2
Volume
40
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Dublin Core
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Title
A name given to the resource
Expression Of Type-specific Mhc Isoforms In Rat Intrafusal Muscle-fibers
Publisher
An entity responsible for making the resource available
Journal of Histochemistry & Cytochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
cat; Cell Biology; differentiation; fiber types; histochemistry; identification; immunocytochemistry; innervation; intrafusal; monoclonal antimyosin antibodies; monoclonal-antibody; motor; muscle fiber typing; muscle spindles; myosin heavy-chain; rat skeletal muscle; skeletal-muscle; spindles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M; Gorza L
Description
An account of the resource
Myosin heavy chain (MHC) expression by intrafusal fibers was studied by immunocytochemistry to determine how closely it parallels MHC expression by extrafusal fibers in the soleus and tibialis anterior muscles of the rat. Among the MHC isoforms expressed in extrafusal fibers, only the slow-twitch MHC of Type 1 extrafusal fibers was expressed along much of the fibers. Monoclonal antibodies (MAb) specific for this MHC bound to the entire length of bag2 fibers and the extracapsular region of bag1 fibers. The fast-twitch MHC isoform strongly expressed by bag2 and chain fibers had an epitope not recognized by MAb to the MHC isoforms characteristic of developing muscle fibers or the three subtypes (2A, 2B, 2X) of Type 2 extrafusal fibers. Therefore, intrafusal fibers may express a fast-twitch MHC that is not expressed by extrafusal fibers. Unlike extrafusal fibers, all three intrafusal fiber types bound MAb generated against mammalian heart and chicken limb muscles. The similarity of the fast-twitch MHC of bag2 and chain fibers and the slow-tonic MHC of bag1 and bag2 fibers to the MHC isoforms expressed in avian extrafusal fibers suggests that phylogenetically primitive MHCs might persist in intrafusal fibers. Data are discussed relative to the origin and regional regulation of MHC isoforms in intrafusal and extrafusal fibers of rat hindlimb muscles.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/40.2.1552171" target="_blank" rel="noreferrer noopener">10.1177/40.2.1552171</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
cat
Cell Biology
differentiation
fiber types
Gorza L
Histochemistry
identification
immunocytochemistry
innervation
intrafusal
Journal Article or Conference Abstract Publication
Journal of Histochemistry & Cytochemistry
Kucera J
monoclonal antimyosin antibodies
monoclonal-antibody
motor
muscle fiber typing
muscle spindles
myosin heavy-chain
rat skeletal muscle
skeletal-muscle
spindles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00266761" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00266761</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
51-57
Issue
1
Volume
96
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Dublin Core
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Title
A name given to the resource
Slow-tonic Mhc Expression In Paralyzed Hindlimbs Of Fetal Rats
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Cell Biology; heavy-chain isoforms; innervation; intrafusal muscle-fibers; numbers; spindles
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
Whether nerve activity and active contraction of myotubes are essential for the assembly and initial differentiation of muscle spindles was investigated by paralyzing fetal rats with tetrodotoxin (TTX) from embryonic day 16 (E16) to E21, prior to and during the period when spindles typically form. TTX-treated soleus muscles were examined by light and electron microscopy for the presence of spindles and expression of myosin heavy chain (MHC) isoforms by the intrafusal fibers. Treatment with TTX did not inhibit the formation of a spindle capsule or the expression of a slow-tonic MHC isoform characteristic of intrafusal fibers, but did retard development of spindles. Spindles of TTX-treated E21 muscles usually consisted of one intrafusal fiber (bag2) only rather than two fibers (bag1 and bag2) typically present in untreated (control) E21 spindles. Intrafusal fibers of TTX-treated spindles also had only one sensory region supplied by multiple afferents, and were devoid of motor innervation. These features are characteristic of spindles in normal E18-E19 muscles. Thus, nerve and/or muscle activity is not essential for the assembly of muscle spindles, formation of a spindle capsule, and transformation of undifferentiated myotubes into the intrafusal fibers containing spindle-specific myosin isoforms. However, activity may promote the maturation of intrafusal bundles, as well as the maturation of afferent and efferent nerve supplies to intrafusal fibers.
Identifier
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<a href="http://doi.org/10.1007/bf00266761" target="_blank" rel="noreferrer noopener">10.1007/bf00266761</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Cell Biology
heavy-chain isoforms
Histochemistry
innervation
intrafusal muscle-fibers
Journal Article or Conference Abstract Publication
Kucera J
numbers
spindles
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00272199" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00272199</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
567-580
Issue
6
Volume
93
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Origin Of Intrafusal Muscle-fibers In The Rat
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00272199" target="_blank" rel="noreferrer noopener">10.1007/bf00272199</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Cell Biology
Histochemistry
Journal Article or Conference Abstract Publication
Kucera J
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00500543" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00500543</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
291-299
Issue
4
Volume
92
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Title
A name given to the resource
Nonuniform Expression Of Myosin Heavy-chain Isoforms Along The Length Of Cat Intrafusal Muscle-fibers
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00500543" target="_blank" rel="noreferrer noopener">10.1007/bf00500543</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Cell Biology
Histochemistry
Journal Article or Conference Abstract Publication
Kucera J
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00500980" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00500980</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
151-160
Issue
2
Volume
90
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Dublin Core
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Title
A name given to the resource
The Effect Of Neonatal Deafferentation Or Deefferentation On Myosin Heavy-chain Expression In Intrafusal Muscle-fibers Of The Rat
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00500980" target="_blank" rel="noreferrer noopener">10.1007/bf00500980</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1988
Cell Biology
Histochemistry
Journal Article or Conference Abstract Publication
Kucera J
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00315994" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00315994</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-390
Issue
5
Volume
96
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Title
A name given to the resource
Aggregation Of Myonuclei And The Spread Of Slow-tonic Myosin Immunoreactivity In Developing Muscle-spindles
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Cell Biology; expression; fibers; heavy-chain isoforms; innervation; motor; rat; skeletal-muscle
Creator
An entity primarily responsible for making the resource
Kucera J; Walro J M
Description
An account of the resource
The pattern of regional expression of a slowtonic myosin heavy chain (MHC) isoform was studied in developing rat soleus intrafusal muscle fibers. Binding of the slow-tonic antibody (ATO) began at the equator of prenatal intrafusal fibers where sensory nerve endings are located, and spread into the polar regions of nuclear bag2 and bag1 fibers but not nuclear chain fibers during ontogeny. The onset of the ATO reactivity coincided with the appearance of equatorial clusters of myonuclei (nuclear bag formations) in bag1 and bag2 fibers. Moreover, the intensity of the ATO reaction was strongest in the region of equatorial myonuclei and decreased with increasing distance from the equator of bag1 and bag2 fibers at all stages of prenatal and postnatal development. The polar expansion of ATO reactivity continued throughout the postnatal development of bag1 fibers, but ceased shortly after birth in bag2 fiber coincident with innervation by motor axons. Thus, afferents that innervate the equator might induce the slow-tonic MHC isoform in bag2 and bag1 fibers by regulating the myosin gene expression by equatorial myonuclei, and efferents or twitch contractile activity might inhibit the spread of the slow-tonic MHC isoform into the poles of bag2 but not bag1 fibers. Absence of ATO binding in chain fibers suggests that chain myotubes may not be as susceptible to the effect of afferents as are myotubes that develop into bag2 and bag1 fibers. The different patterns of slow-tonic MHC expression in the three types of intrafusal fiber may therefore result from the interaction of three elements: sensory neurons, motor neurons, and intrafusal myotubes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00315994" target="_blank" rel="noreferrer noopener">10.1007/bf00315994</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Cell Biology
expression
fibers
heavy-chain isoforms
Histochemistry
innervation
Journal Article or Conference Abstract Publication
Kucera J
motor
rat
skeletal-muscle
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/01.bpo.0000188994.90931.e8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.bpo.0000188994.90931.e8</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
91-93
Issue
1
Volume
26
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Title
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Histologic And Histochemical Analysis Of Muscle Specimens In Idiopathic Talipes Equinovarus
Publisher
An entity responsible for making the resource available
Journal of Pediatric Orthopaedics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-01
Subject
The topic of the resource
club foot; club foot; congenital clubfoot; etiology; histochemistry; muscle biopsy; Orthopedics; pathogenesis; Pediatrics
Creator
An entity primarily responsible for making the resource
Herceg M B; Weiner D S; Agamanolis D P; Hawk D
Description
An account of the resource
Congenital idiopathic talipes equinovarus is a relatively common disorder of uncertain etiology with a wide variance of clinical severity. Many theories have been postulated over the years without universal agreement in regard to the cause of this disorder. These hypotheses include vascular, viral, genetic, anatomic, compartment syndrome, environmental,(13) and positioning considerations.` A great deal of recent discussion has focused on a neuromuscular etiology for this condition. Muscle biopsies from the gastrocnermus, abductor hallucis, flexor digitorum longus, flexor hallucis, and tibialis posterior were obtained during posteromedial surgical release for idiopathic talipes equinovarus from September 1994 to October 2000 at the authors' institution. Ninety-five feet in 68 patients yielded a total of 431 muscle specimens. All of the specimens were processed and examined by light microscopy by an expert neuromuscular pathologist. In addition, 95 tissue samples were further processed for histochemical studies and electron microscopy. Three hundred seventy-two specimens (86.3%) showed no evidence of a pathologic diagnosis with normal fiber-type ratios and no type I fiber grouping indicative of neuromuscular pathology. Only 4 specimens (0.9%) showed type I fiber predominance, and 55 specimens (12.8%) revealed muscle fiber atrophy. The results of this study do not support the theory that a neurormiscular abnormality may be significant in the etiology of idiopathic talipes equinovarus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.bpo.0000188994.90931.e8" target="_blank" rel="noreferrer noopener">10.1097/01.bpo.0000188994.90931.e8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
Agamanolis D P
club foot
congenital clubfoot
Etiology
Hawk D
Herceg M B
Histochemistry
Journal Article or Conference Abstract Publication
Journal of Pediatric Orthopaedics
muscle biopsy
Orthopedics
Pathogenesis
Pediatrics
Weiner D S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00495009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00495009</a>
Pages
1–13
Issue
1
Volume
92
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Innervation of regenerated spindles in muscle grafts of the rat.
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1905-06
Subject
The topic of the resource
Female; Animals; Rats; Cell Differentiation; *Nerve Regeneration; Adenosine Triphosphatases/analysis; Graft Survival; Histocytochemistry; Motor Neurons/enzymology/metabolism/*physiology; Muscle Spindles/enzymology/*physiology; Muscles/transplantation; Nerve Fibers/enzymology/physiology; Neurons; Inbred Strains; Afferent/enzymology/metabolism/*physiology
Creator
An entity primarily responsible for making the resource
Walro J M; Kucera J; Cui F; Staffeld C G
Description
An account of the resource
Features of the nerve supply and the encapsulated fibers of muscle spindles were assessed in grafted and normal extensor digitorum longus (EDL) muscles of rats by analysis of serial 10-microns frozen transverse sections stained for enzymes which delineated motor and sensory endings, oxidative capacity and muscle fiber type. The number of fibers was significantly more variable, and branched fibers were more frequently observed in regenerated spindles than in control spindles. Forty-eight percent of regenerated spindles received sensory innervation. Spindles reinnervated by afferents had a larger periaxial space than did spindles which were not reinnervated by afferents. Regenerated fibers innervated by afferents had small cross-sectional areas, equatorial regions with myofibrils restricted to the periphery of fibers, unpredictable patterns of nonuniform and nonreversible staining along the length of the fiber for 'myofibrillar' adenosine triphosphatase (mATPase) after acid and alkaline preincubation. In contrast, regenerated fibers devoid of sensory innervation resembled extrafusal fibers in that they usually exhibited myofibrils throughout the length of the fiber, no central aggregations of myonuclei, uniform staining for mATPase and a reversal of staining for mATPase after preincubation in an acid or alkaline medium. Approximately thirty percent of encapsulated fibers devoid of sensory innervation stained analogous to a type I extrafusal fiber, a pattern of staining never observed in intrafusal fibers of normal spindles. Groups of encapsulated fibers all exhibiting this pattern of staining reflect that either these fibers may have been innervated by collaterals of skeletomotor axons that originally innervated type I extrafusal fibers or that fibers innervated by only fusimotor neurons express patterns of staining for mATPase similar to extrafusal fibers in the absence of sensory innervation. Sensory innervation may also influence the reestablishment of multiple sites of motor endings on regenerated intrafusal fibers. Those regenerated fibers innervated by afferents had more motor endings than did regenerated fibers devoid of sensory innervation. Differences in size, morphology, and patterns of staining for mATPase and numbers of motor endings between fibers innervated by afferents and fibers devoid of sensory innervation reflect that afferents can influence the differentiation of muscle cells and the reestablishment of motor innervation other than during the late prenatal/early postnatal period when muscle spindles form and differentiate in rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00495009" target="_blank" rel="noreferrer noopener">10.1007/bf00495009</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Nerve Regeneration
1989
Adenosine Triphosphatases/analysis
Afferent/enzymology/metabolism/*physiology
Animals
Cell Differentiation
Cui F
Female
Graft Survival
Histochemistry
Histocytochemistry
Inbred Strains
Kucera J
Motor Neurons/enzymology/metabolism/*physiology
Muscle Spindles/enzymology/*physiology
Muscles/transplantation
Nerve Fibers/enzymology/physiology
Neurons
Rats
Staffeld C G
Walro J M