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Text
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<a href="http://doi.org/10.1016/j.bone.2020.115470" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bone.2020.115470</a>
Pages
115470
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Student Publications
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Title
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The role of miR-150 regulates bone cell differentiation and function.
Publisher
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Bone
Date
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2020
2020-06
Subject
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Histomorphometry; Micro-CT; miRNA-150; Osteoactivin/GPNMB; Osteoblast; Osteoclast
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Moussa FM; Cook Bryson P; Sondag GR; DeSanto M; Obri MS; McDermott SE; Safadi FF
Description
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BACKGROUND: mir-RNAs play a role in regulating bone homeostasis. In this study we assessed the functional role of mir-RNA 150 in bone homeostasis. We also assess the effects of miR-150 deficiency on osteoblast and osteoclast differentiation and function using in vivo and in vitro approaches. METHODS: Wild type (WT) (C57BL/6J) and miR-150 KO mice were compared for a variety of parameters. Micro-CT imaging was conducted to quantify trabecular bone mass inferior to the distal growth plate of the femur. Von Kossa staining was performed for osteoblast culture mineralization.
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<a href="http://doi.org/10.1016/j.bone.2020.115470" target="_blank" rel="noreferrer noopener">10.1016/j.bone.2020.115470</a>
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journalArticle
2020
Bone
Cook Bryson P
Department of Anatomy & Neurobiology
Desanto M
Histomorphometry
journalArticle
July 2020 List
McDermott SE
Micro-CT
miRNA-150
Moussa FM
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Obri MS
Osteoactivin/GPNMB
OSTEOBLAST
osteoclast
Safadi FF
Sondag GR