1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.phrs.2017.08.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.phrs.2017.08.007</a> Pages 73–79 Volume 128 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. Publisher An entity responsible for making the resource available Pharmacological research Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-02 Subject The topic of the resource *DNA methylation; *Epigenetics; *HDACs; *lncRNA; *miRNA; *Osteoarthritis; Animals; Epigenesis; Genetic; Histone Deacetylase Inhibitors/*therapeutic use; Humans; Osteoarthritis/*drug therapy/*genetics Creator An entity primarily responsible for making the resource Khan Nazir M; Haqqi Tariq M Description An account of the resource Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications. The aim of this review is to briefly highlight the recent advances in the epigenetics of cartilage and potential of HDACs (Histone deacetylases) inhibitors in the therapeutic management of OA. We summarize the recent studies utilizing HDAC inhibitors as potential therapeutics for inhibiting disease progression and preventing the cartilage destruction in OA. HDACs control normal cartilage development and homeostasis and understanding the impact of HDACs inhibitors on the disease pathogenesis is of interest because of its importance in affecting overall cartilage health and homeostasis. These findings also shed new light on cartilage disease pathophysiology and provide substantial evidence that HDACs may be potential novel therapeutic targets in OA. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.phrs.2017.08.007" target="_blank" rel="noreferrer noopener">10.1016/j.phrs.2017.08.007</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *DNA methylation *Epigenetics *HDACs *lncRNA *miRNA *OSTEOARTHRITIS 2018 Animals Department of Anatomy & Neurobiology Epigenesis Genetic Haqqi Tariq M Histone Deacetylase Inhibitors/*therapeutic use Humans Khan Nazir M NEOMED College of Medicine Osteoarthritis/*drug therapy/*genetics Pharmacological research