1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnagi.2020.00027" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnagi.2020.00027</a>
Pages
27-27
Volume
12
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fnagi.2020.00027" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fnagi.2020.00027</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology; NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Density of Perineuronal Nets Increases With Age in the Inferior Colliculus in the Fischer Brown Norway Rat.
Publisher
An entity responsible for making the resource available
Frontiers in aging neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
1905-07
Subject
The topic of the resource
aging; inferior colliculus; GABAergic; perineuronal nets; Wisteria floribunda agglutinin
Creator
An entity primarily responsible for making the resource
Mafi Amir M; Hofer Lindsay N; Russ Matthew G; Young Jesse W; Mellott Jeffrey G
Description
An account of the resource
Age-related hearing loss, one of the most frequently diagnosed disabilities in industrialized countries, may result from declining levels of GABA in the aging inferior colliculus (IC). However, the mechanisms of aging and subsequent disruptions of temporal processing in elderly hearing abilities are still being investigated. Perineuronal nets (PNs) are a specialized form of the extracellular matrix and have been linked to GABAergic neurotransmission and to the regulation of structural and synaptic plasticity. We sought to determine whether the density of PNs in the IC changes with age. We combined Wisteria floribunda agglutinin (WFA) staining with immunohistochemistry to glutamic acid decarboxylase in three age groups of Fischer Brown Norway (FBN) rats. The density of PNs on GABAergic and non-GABAergic cells in the three major subdivisions of the IC was quantified. Results first demonstrate that the density of PNs in the FBN IC increase with age. The greatest increases of PN density from young to old age occurred in the central IC (67% increase) and dorsal IC (117% increase). Second, in the young IC, PNs surround non-GABAergic and GABAergic cells with the majority of PNs surrounding the former. The increase of PNs with age in the IC occurred on both non-GABAergic and GABAergic populations. The average density of PN-surrounded non-GABAergic cells increased from 84.9 PNs/mm(2) in the young to 134.2 PNs/mm(2) in the old. While the density of PN-surrounded GABAergic cells increased from 26 PNs/mm(2) in the young to 40.6 PNs/mm(2) in the old. The causality is unclear, but increases in PN density in old age may play a role in altered auditory processing in the elderly, or may lead to further changes in IC plasticity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnagi.2020.00027" target="_blank" rel="noreferrer noopener">10.3389/fnagi.2020.00027</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2020
Aging
Department of Anatomy & Neurobiology
Frontiers in aging neuroscience
GABAergic
Hofer Lindsay N
inferior colliculus
Mafi Amir M
Mellott Jeffrey G
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
perineuronal nets
Russ Matthew G
Wisteria floribunda agglutinin
Young Jesse W