1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1016/s0002-9378(97)70606-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0002-9378(97)70606-9</a>
Pages
819–23; discussion 823–825
Issue
4
Volume
176
Dublin Core
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Title
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The effect of intermittent-release intraperitoneal chemotherapy on wound healing.
Publisher
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American journal of obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-04
Subject
The topic of the resource
Animals; Antineoplastic Agents/administration & dosage/*pharmacology; Carboplatin/administration & dosage/*pharmacology; Infusions; Laparotomy; Male; Paclitaxel/administration & dosage/*pharmacology; Parenteral; Rats; Sprague-Dawley; Tissue Adhesions/chemically induced; Wound Healing/*drug effects
Creator
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Hopkins M P; von Gruenigen V E; Holda S; Weber B
Description
An account of the resource
OBJECTIVE: Our purpose was to study the effect on wound healing when intraperitoneal chemotherapy was instilled on a daily basis. STUDY DESIGN: Intraperitoneal carboplatin, Taxol, or saline solution was instilled daily into 70 rats after they underwent laparotomy. The animals were killed and analyzed for adhesions. An area measuring 5 x 5 cm including the incision was also harvested for biomechanical testing. The wound thickness was measured, and the Shore Western Materials Testing System (Monrovia, Calif.) was used to test the force required to break the wound, the stress, and the stiffness. RESULTS: Groups of 10 rats received saline solution control, carboplatin 6 mg/kg, 7 mg/kg, 8 mg/kg, or Taxol 2.5 mg/kg, 3.0 mg/kg, or 3.5 mg/kg. The total dose was divided into seven equal amounts, administered daily. No significant adhesions developed in any of the animals. The carboplatin group experienced no significant decrease in wound thickness whereas the higher-dose Taxol group had a significant decrease in thickness from 1.06 mm to 0.72 mm (p = 0.02). The wound-breaking strength (force) also decreased for the highest-dose Taxol group from 710 gm to 411 gm (p = 0.02). The wound stiffness was also decreased from 69 gm/mm to 46 gm/mm (p = 0.01). The other measured parameters for both the Taxol and carboplatin groups were not significantly decreased when compared with those of controls. CONCLUSION: The immediate instillation of divided daily carboplatin did not influence wound strength whereas the use of Taxol on a similar schedule significantly decreased wound strength.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0002-9378(97)70606-9" target="_blank" rel="noreferrer noopener">10.1016/s0002-9378(97)70606-9</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
American journal of obstetrics and gynecology
Animals
Antineoplastic Agents/administration & dosage/*pharmacology
Carboplatin/administration & dosage/*pharmacology
Holda S
Hopkins M P
Infusions
Laparotomy
Male
Paclitaxel/administration & dosage/*pharmacology
Parenteral
Rats
Sprague-Dawley
Tissue Adhesions/chemically induced
von Gruenigen V E
Weber B
Wound Healing/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0002-9378(99)70372-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0002-9378(99)70372-8</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1329-1333
Issue
6
Volume
181
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The Effects Of Carbon Dioxide Pneumoperitoneum On Seeding Of Tumor In Port Sites In A Rat Model
Publisher
An entity responsible for making the resource available
American Journal of Obstetrics and Gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-12
Subject
The topic of the resource
colon cancer; implantation; laparoscopy; Obstetrics & Gynecology; ovarian cancer; rats; recurrence; tumor implantation
Creator
An entity primarily responsible for making the resource
Hopkins M P; Dulai R M; Occhino A; Holda S
Description
An account of the resource
OBJECTIVES: The use of laparoscopic surgical techniques for the resection of intraperitoneal malignancies has been rapidly increasing in recent years; concomitantly, tumor recurrences at trocar sites have also been reported. These reports bring into question the appropriateness of pneumoperitoneum and laparoscopic techniques for carcinoma removal. We hypothesized that the carbon dioxide pneumoperitoneum and instrumentation used during laparoscopic procedures contribute to a greater incidence of tumor implantation into the ventral peritoneal wall wound sites than seen with laparotomy. This study, which used port placement and carbon dioxide pneumoperitoneum in an animal model, was designed to determine the relative incidences of tumor implantation into wound sites of the ventral peritoneal wall for laparoscopy and laparotomy STUDY DESIGN: Viable MAT B III rat mammary adenocarcinoma cells were injected into the lower right quadrant of the peritoneal cavity of Fisher 344 rats (1 x 10(5) cells/rat). The animals were then divided into 4 groups: 1 group (n = 9) served as a control group and received no further manipulations; another (n = 8) underwent a midline laparotomy; another (n = 8) had four 18-gauge trocars inserted into the peritoneal cavity; and the last (n = 8) underwent induction of a 7- to 8-mm Hg carbon dioxide pneumoperitoneum in addition to the insertion of four 18-gauge trocars. All animals were maintained under surgical conditions for 2 hours. Animals were killed at 7 days, and the ventral peritoneal wall was examined for macroscopic evidence of tumor formation. RESULTS: A total of 32 possible sites of tumor implantation were measured. The control group showed no significant macroscopic evidence of tumor translocation tio the ventral peritoneal wall. Among the 32 measured sites the laparotomy group had an overall lower incidence of tumor implantation at the peritoneal wall wound sites (n = 5) than did the group with the trocars alone (n = 20) group (P = .003) and the group with trocars plus carbon dioxide insufflation (n = 29, P < .0001). The group with trocars alone had a lower incidence of tumor implantation than did the group with trocars plus carbon dioxide pneumoperitoneum (P = .02). CONCLUSIONS: Trocar use during laparoscopic surgical procedures led to greater translocation of free tumor cells to peritoneal wall wound sites than did laparotomy in this animal model. The addition of carbon dioxide pneumoperitoneum further increased implantation of tumor cells at trocar sites. These results provide evidence that the use of laparoscopic techniques for resection of intraperitoneal malignancy needs further long-term study.
Identifier
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<a href="http://doi.org/10.1016/s0002-9378(99)70372-8" target="_blank" rel="noreferrer noopener">10.1016/s0002-9378(99)70372-8</a>
Format
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Journal Article or Conference Abstract Publication
1999
American journal of obstetrics and gynecology
colon cancer
Dulai R M
Holda S
Hopkins M P
implantation
Journal Article or Conference Abstract Publication
Laparoscopy
Obstetrics & Gynecology
Occhino A
Ovarian cancer
Rats
Recurrence
tumor implantation