Immune response to nonspecific and altered tissue antigens in soft tissue allografts.
Anti-Infective Agents; Articular/immunology/physiology/*transplantation; Biomechanical Phenomena; Bone Transplantation/*immunology; Cells; Cultured; Ethanol/pharmacology; Fibroblasts/drug effects; Homologous; Humans; Hydrogen Peroxide/pharmacology; Ligaments; Local/pharmacology; Povidone-Iodine/pharmacology; Therapeutic Irrigation; Tissue Preservation; Transplantation
Soft tissue allografts have many uses in orthopaedic surgery, including knee ligament reconstruction, hand tendon surgery, shoulder instability, and rotator cuff reconstruction. The predictable biologic incorporation of soft tissue allografts without rejection or fear of disease transmission continues to be a goal of basic science researchers. A review of the current knowledge if the immune system response to donor specific, nonspecific, and altered tissue antigens in soft tissue or tendon allografts is presented. An in vitro study was done in an attempt to decrease immunogenicity of a frozen bone-ligament graft by adding irrigation with Betadine scrub solution and hydrogen peroxide to the conventional storage process of freezing. Although the irrigation with cytotoxic agents would undoubtedly further decrease immunogenicity, it also decreased stiffness and maximum load by 15%. Whether this decreased strength and stiffness would compromise the incorporation and long term success of soft tissue allografts would need to be studied by in vitro experiments.
Pinkowski J L; Rodrigo J J; Sharkey N A; Vasseur P B
Clinical orthopaedics and related research
1996
1996-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1097/00003086-199605000-00010" target="_blank" rel="noreferrer noopener">10.1097/00003086-199605000-00010</a>
Fresh-frozen osteochondral allograft reconstruction of a giant cell tumor of the talus.
*Bone Transplantation; *Talus; Adult; Bone Neoplasms/*surgery; Female; Freezing; Giant Cell Tumor of Bone/*surgery; Homologous; Humans; Recurrence; Transplantation
The use of fresh-frozen osteochondral allografts has been reported for the treatment of talar fractures, osteochondral lesions, and tumors of the calcaneus. Currently, we are unaware of any reports in the literature addressing the use of fresh-frozen osteochondral allograft for the treatment of giant cell tumors in the talus. We report our attempt to eradicate an aggressive giant cell tumor of the talus while minimizing morbidity and loss of function via reconstruction with a fresh-frozen osteochondral allograft. This is the first report in the literature to propose such a treatment option for giant cell tumors in the talus. The patient was informed that a report of this case would be submitted for publication.
Schoenfeld Andrew J; Leeson Mark C; Grossman Jordan P
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
2007
2007-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1053/j.jfas.2006.10.004" target="_blank" rel="noreferrer noopener">10.1053/j.jfas.2006.10.004</a>