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40
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Text
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URL Address
<a href="http://doi.org/10.1002/hep4.1487" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep4.1487</a>
Pages
527-539
Issue
4
Volume
4
ISSN
2471-254X 2471-254X
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine; NEOMED College of Graduate Studies
NEOMED Department
Department of Integrative Medical Sciences; NEOMED Postdoc Publications
Dublin Core
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Title
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Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice.
Publisher
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Hepatology communications
Date
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2020
2020-04
Subject
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decreases blood-lipids; deficiency; dyslipidemia; hepatic steatosis; lipotoxicity; Liver; protects; receptor-alpha; reduces atherosclerosis; transgenic expression
Creator
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Xu Yanyong; Zhu Yingdong; Bawa Fathima Cassim; Hu Shuwei; Pan Xiaoli; Yin Liya; Zhang Yanqiao
Description
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Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions. In this study, we investigate the role of human CES1 in the development of steatohepatitis or dyslipidemia in C57BL/6 mice. Hepatocyte-specific expression of human CES1 prevented Western diet or alcohol-induced steatohepatitis and hyperlipidemia. Mechanistically, human CES1 induced lipolysis and fatty acid oxidation, leading to a reduction in hepatic triglyceride and free fatty acid levels. Human CES1 also reduced hepatic-free cholesterol levels and induced low-density lipoprotein receptor. In addition, human CES1 induced hepatic lipoprotein lipase and apolipoprotein C-II expression. Conclusion: Hepatocyte-specific overexpression of human CES1 attenuates diet-induced steatohepatitis and hyperlipidemia.
Identifier
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<a href="http://doi.org/10.1002/hep4.1487" target="_blank" rel="noreferrer noopener">10.1002/hep4.1487</a>
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journalArticle
2020
Bawa Fathima Cassim
decreases blood-lipids
deficiency
Department of Integrative Medical Sciences
dyslipidemia
hepatic steatosis
Hepatology communications
Hu Shuwei
Journal Article
journalArticle
June 2020 Update I
lipotoxicity
Liver
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
Pan Xiaoli
protects
receptor-alpha
reduces atherosclerosis
transgenic expression
Xu Yanyong
Yin Liya
Zhang Yanqiao
Zhu Yingdong