In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles
Creator
Hong W X; Hu R F; Huang X C; Lu X Q; Czech T; Tang J H
Publisher
Journal of Drug Delivery Science and Technology
Date
2017
2017-10
Description
Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect, folate-conjugated PAA-PPA micelles were synthesized. To evaluate the hypothesis, we assessed the pharmacokinetics and biodistribution of.a new antitumor drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR) loaded into the micelles. We also observed in vivo imaging of 1,1'-dioctadecy1-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) loaded micelles to confirm distribution. The results showed that ATPR-loaded, folate-modified PAA-PPA displayed a prolonged circulation half-life and iinproved the targeting effect. (C) 2017 Elsevier B.V. All tights reserved.