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40
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Text
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<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
N.PAG-N.PAG
Issue
1
Volume
6
ISSN
23288957
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open Forum Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
antimicrobial resistance; carbapenem-resistant enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Duin David van
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Clev eland Clinic Akron General Hosptial
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Duin David van
Evans Scott
Fowler Vance G
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Journal Article
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
November 2019 Update
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
Pages
ofy351–ofy351
Issue
1
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofx157</a>
Pages
ofx157–ofx157
Issue
3
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-7
Subject
The topic of the resource
carbapenem-resistant Enterobacteriaceae; Klebsiella pneumoniae; ST258; surgical site infections; wound infection
Creator
An entity primarily responsible for making the resource
Henig Oryan; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Marshall Steve; Rudin Susan D; Domitrovic T Nicholas; Hujer Andrea M; Hujer Kristine M; Doi Yohei; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David; Kaye Keith S
Description
An account of the resource
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed. Molecular typing of isolates was performed using repetitive extragenic palindromic polymerase chain reaction (PCR). Carbapenemase genes were detected using PCR. RESULTS: One hundred forty-two patients were included: 62 had SSTI (44%) and 56% were colonized. Mean age was 61 years, and 48% were male: median Charlson score was 3 (interquartile range, 1-5). Forty-eight percent of patients were admitted from long-term care facilities (LTCFs), and 31% were from the community. Two strain types (ST258A and ST258B) were identified (73% of 45 tested). Carbapenemase genes were detected in 40 of 45 isolates (blaKPC-3 [47%], blaKPC-2 [42%]). Sixty-eight patients (48%) underwent surgical intervention, 63% of whom had SSTI. Patients admitted from LTCFs were less likely to undergo surgical intervention (odds ratio [OR], 0.36; 95% confidence interval [CI], 0.18-0.71). In multivariable analysis, among patients with SSTI, those admitted from LTCFs were less likely to undergo debridement (OR, 0.18; 95% CI, 0.04-0.93). CONCLUSIONS: Patients admitted from LTCFs with CRE SSTI were less likely to undergo surgical intervention. Sixteen percent of the patients died, and approximately 50% of survivors required more intensive care upon discharge. These findings suggest a unique, impactful syndrome within the CRE infection spectrum. Further studies are needed to assess the role of surgical debridement in management of CRE-SSTI, particularly among LTCF residents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofx157</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henig Oryan
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumoniae
Marshall Steve
NEOMED College of Medicine
Open forum infectious diseases
Perez Federico
Richter Sandra S
Rudin Susan D
Salata Robert A
ST258
surgical site infections
van Duin David
Watkins Richard R
wound infection
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciw805" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciw805</a>
Pages
711–718
Issue
6
Volume
64
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*beta-Lactam Resistance; *carbapenem-resistant Enterobacteriaceae; *colistin; *Klebsiella pneumoniae; *mortality; *ST258; Aged; Anti-Bacterial Agents/pharmacology/*therapeutic use; beta-Lactamases/genetics; Carbapenems/pharmacology/therapeutic use; Colistin/pharmacology/*therapeutic use; Comorbidity; Female; Humans; Kaplan-Meier Estimate; Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality; Klebsiella pneumoniae/classification/*drug effects/genetics; Male; Microbial Sensitivity Tests; Middle Aged; Phylogeny; Proportional Hazards Models
Creator
An entity primarily responsible for making the resource
Rojas Laura J; Salim Madiha; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Marshall Steve; Rudin Susan D; Domitrovic T Nicholas; Hujer Andrea M; Hujer Kristine M; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David
Description
An account of the resource
Background: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide. Methods: A cohort nested within the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRACKLE) was constructed of patients with infection, or colonization with CRKp isolates tested for colistin susceptibility during the study period of December, 2011 to October, 2014. Reference colistin resistance determination as performed by broth macrodilution was compared to results from clinical microbiology laboratories (Etest) and to polymyxin resistance testing. Each patient was included once, at the time of their first colistin-tested CRKp positive culture. Time to 30-day in-hospital all-cause mortality was evaluated by Kaplan-Meier curves and Cox proportional hazard modeling. Results: In 246 patients with CRKp, 13% possessed ColR CRKp. ColR was underestimated by Etest (very major error rate = 35%, major error rate = 0.4%). A variety of rep-PCR strain types were encountered in both the ColS and the ColR groups. Carbapenem resistance was mediated primarily by blaKPC-2 (46%) and blaKPC-3 (50%). ColR was associated with increased hazard for in-hospital mortality (aHR 3.48; 95% confidence interval, 1.73-6.57; P \textless .001). The plasmid-associated ColR genes, mcr-1 and mcr-2 were not detected in any of the ColR CRKp. Conclusions: In this cohort, 13% of patients with CRKp presented with ColR CRKp. The apparent polyclonal nature of the isolates suggests de novo emergence of ColR in this cohort as the primary factor driving ColR. Importantly, mortality was increased in patients with ColR isolates.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciw805" target="_blank" rel="noreferrer noopener">10.1093/cid/ciw805</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*beta-Lactam Resistance
*carbapenem-resistant Enterobacteriaceae
*Colistin
*Klebsiella pneumoniae
*mortality
*ST258
2017
Aged
Anti-Bacterial Agents/pharmacology/*therapeutic use
beta-Lactamases/genetics
Bonomo Robert A
Carbapenems/pharmacology/therapeutic use
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Cober Eric
Colistin/pharmacology/*therapeutic use
Comorbidity
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Female
Fowler Vance G Jr
Hujer Andrea M
Hujer Kristine M
Humans
Kalayjian Robert C
Kaplan-Meier Estimate
Kaye Keith S
Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality
Klebsiella pneumoniae/classification/*drug effects/genetics
Male
Marshall Steve
Microbial Sensitivity Tests
Middle Aged
NEOMED College of Medicine
Perez Federico
Phylogeny
Proportional Hazards Models
Richter Sandra S
Rojas Laura J
Rudin Susan D
Salata Robert A
Salim Madiha
van Duin David
Watkins Richard R