1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s007050200024" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s007050200024</a>
Pages
763–773
Issue
4
Volume
147
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The ability of an HSV strain to initiate zosteriform spread correlates with its neuroinvasive disease potential.
Publisher
An entity responsible for making the resource available
Archives of virology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Animal; Animals; Disease Models; Ganglia; Herpes Simplex/*physiopathology/virology; Herpesvirus 1; Human/*pathogenicity; Inbred BALB C; Mice; Skin Diseases/*physiopathology/virology; Spinal/*virology; Time Factors; Virulence
Creator
An entity primarily responsible for making the resource
Goel N; Mao H; Rong Q; Docherty J J; Zimmerman D; Rosenthal K S
Description
An account of the resource
The requirements for disease development in the mouse epidermal scarification-zosteriform model of HSV infection are likely to parallel those required for primary HSV disease of humans. HSV-1 strains, which are neuroinvasive in the mouse footpad model of HSV encephalitis, caused local site lesions within 3 days and secondary zosteriform lesions along the dermatome within approximately 5 days. HSV-1 strains, which are not neuroinvasive, failed to progress to zosteriform lesion development and local site lesions were mild or absent. Relative differences in the rate and extent of zosteriform lesion development paralleled the behavior of the viruses in the mouse footpad model of neuroinvasion. In conclusion, the viral properties which are important for neuroinvasiveness appear to also determine the ability of an HSV strain to cause zosteriform disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s007050200024" target="_blank" rel="noreferrer noopener">10.1007/s007050200024</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animal
Animals
Archives of virology
Disease Models
Docherty J J
Ganglia
Goel N
Herpes Simplex/*physiopathology/virology
Herpesvirus 1
Human/*pathogenicity
Inbred BALB C
Mao H
Mice
Rong Q
Rosenthal K S
Skin Diseases/*physiopathology/virology
Spinal/*virology
Time Factors
Virulence
Zimmerman D