Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats.
Wilkinson GS; Adams DM; Haghani A; Lu AT; Zoller J; Breeze CE; Arnold BD; Ball HC; Carter GG; Cooper LN; Dechmann DKN; Devanna P; Fasel NJ; Galazyuk AV; Günther L; Hurme E; Jones G; Knörnschild M; Lattenkamp EZ; Li CZ; Mayer F; Reinhardt JA; Medellin RA; Nagy M; Pope B; Power ML; Ransome RD; Teeling EC; Vernes SC; Zamora-Mejías D; Zhang J; Faure PA; Greville LJ; Horvath S; Herrera MLG; Flores-Martínez JJ
Nature Communications
2021
2021-05-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1038/s41467-021-23129-5" target="_blank" rel="noreferrer noopener">10.1038/s41467-021-23129-5</a>
DNA methylation predicts age and provides insight into exceptional longevity of bats.
DNA Methylation; Aging/genetics; Animals; Carcinogenesis/genetics; Chiroptera/genetics; Chromatin; Epigenesis Genetic; Genetic Techniques; Histones; Immunity Innate/genetics; Longevity/genetics; Phylogeny
Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.
Wilkinson GS; Adams DM; Haghani A; Lu AT; Zoller J; Breeze CE; Arnold BD; Ball HC; Carter GG; Cooper LN; Dechmann DKN; Devanna P; Fasel NJ; Galazyuk AV; Günther L; Hurme E; Jones G; Knörnschild M; Lattenkamp EZ; Li CZ; Mayer F; Reinhardt JA; Medellin RA; Nagy M; Pope B; Power ML; Ransome RD; Teeling EC; Vernes Sonja C; Zamora-Mejías D; Zhang J; Faure PA; Greville LJ; Horvath S
Nature Communications
2021
2021-03-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1038/s41467-021-21900-2" target="_blank" rel="noreferrer noopener">10.1038/s41467-021-21900-2</a>