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Text
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URL Address
<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/1465-9921-8-27</a>
Pages
27–27
Volume
8
Dublin Core
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Title
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Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.
Publisher
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Respiratory research
Date
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2007
2007-03
Subject
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Absorption/drug effects; Animal/*metabolism; Animals; Body Fluids/*metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Fetus/metabolism; Gestational Age; Guinea Pigs; Hydrocortisone/*metabolism; Injections; Interleukin-1beta/administration & dosage/*pharmacology; Lung/*embryology; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/*metabolism; Pregnancy; Rats; Recombinant Proteins/administration & dosage/pharmacology; Subcutaneous
Creator
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Bhattacharjee Reshma; Li Tianbo; Koshy Shyny; Beard LaMonta L; Sharma Kapil; Carter Ethan P; Garat Chrystelle; Folkesson Hans G
Description
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BACKGROUND: We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. METHODS: IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5% albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP kinase expression was measured by western blot. RESULTS: Lung fluid absorption was induced at 61 days (D) gestation and stimulated at 68D gestation by IL-1beta. Maternal IL-1beta pretreatment upregulated ERK and upstream MEK expression at both 61 and 68D gestation, albeit being much more pronounced at 61D gestation. U0126 instillation completely blocked IL-1beta-induced lung fluid absorption as well as IL-1beta-induced/stimulated ERK expression. Cortisol synthesis inhibition by metyrapone attenuated ERK expression and lung fluid absorption in IL-1beta-pretreated fetal lungs. JNK expression after maternal
Identifier
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<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">10.1186/1465-9921-8-27</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Absorption/drug effects
Animal/*metabolism
Animals
Beard LaMonta L
Bhattacharjee Reshma
Body Fluids/*metabolism
Carter Ethan P
Extracellular Signal-Regulated MAP Kinases/metabolism
Female
Fetus/metabolism
Folkesson Hans G
Garat Chrystelle
Gestational Age
Guinea Pigs
Hydrocortisone/*metabolism
Injections
Interleukin-1beta/administration & dosage/*pharmacology
Koshy Shyny
Li Tianbo
Lung/*embryology
Mitogen-Activated Protein Kinase Kinases/metabolism
Mitogen-Activated Protein Kinases/*metabolism
Pregnancy
Rats
Recombinant Proteins/administration & dosage/pharmacology
Respiratory research
Sharma Kapil
Subcutaneous