1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1200/jco.2007.15.0326" target="_blank" rel="noreferrer noopener">http://doi.org/10.1200/jco.2007.15.0326</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 791-797 Issue 5 Volume 26 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: A National Cancer Institute conference Publisher An entity responsible for making the resource available Journal of Clinical Oncology Date A point or period of time associated with an event in the lifecycle of the resource 2008 2008-02 Subject The topic of the resource Oncology; reconstruction; neoadjuvant chemotherapy; mastectomy; lymph-node biopsy; mri; b-27; local-regional recurrence; pathological tumor size; postmastectomy radiation improves; project protocol; surgical adjuvant breast Creator An entity primarily responsible for making the resource Buchholz T A; Lehman C D; Harris J R; Pockaj B A; Khouri N; Hylton N F; Miller M J; Whelan T; Pierce L J; Esserman L J; Newman L A; Smith B L; Bear H D; Mamounas E P Description An account of the resource Purpose To review the state of the science with respect to diagnostic imaging and locoregional therapy for patients with breast cancer receiving preoperative chemotherapy. Methods Published data relevant to clinical staging, monitoring of tumor response, and locoregional therapy for patients with breast cancer treated with preoperative chemotherapy were reviewed. Results High-quality data from prospective randomized trials are limited. Available data suggest that locoregional therapy decisions should be based on both the pretreatment clinical extent of disease and the pathologic extent of the disease after chemotherapy. Accordingly, physical examination and imaging studies that accurately define the initial extent of disease are required before treatment. Sentinel lymph node biopsy can be performed either before or after preoperative chemotherapy for patients with clinical N0 disease. The success of breast conservation after preoperative chemotherapy depends on careful patient selection and achieving negative surgical margins. Adjuvant breast radiation is indicated for all patients treated with breast conservation. For patients treated with mastectomy, chest-wall and regional nodal radiation should be considered for those who present with clinical stage III disease or have histologically positive lymph nodes after preoperative chemotherapy. Additional prospective studies are needed to determine the value of postmastectomy radiation for patients with stage II breast cancer who have negative lymph nodes after chemotherapy. Conclusion The increased use of preoperative chemotherapy has raised new questions concerning the optimal methods to stage and monitor disease response to treatment and how to optimize locoregional treatment. The available evidence suggests that a multidisciplinary approach improves outcomes. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1200/jco.2007.15.0326" target="_blank" rel="noreferrer noopener">10.1200/jco.2007.15.0326</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2008 b-27 Bear H D Buchholz T A Esserman L J Harris J R Hylton N F Journal Article or Conference Abstract Publication Journal of Clinical Oncology Khouri N Lehman C D local-regional recurrence lymph-node biopsy Mamounas E P Mastectomy Miller M J MRI neoadjuvant chemotherapy Newman L A oncology pathological tumor size Pierce L J Pockaj B A postmastectomy radiation improves project protocol reconstruction Smith B L surgical adjuvant breast Whelan T