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Text
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URL Address
<a href="http://doi.org/10.1139/cjpp-2013-0490" target="_blank" rel="noreferrer noopener">http://doi.org/10.1139/cjpp-2013-0490</a>
Pages
598–604
Issue
7
Volume
92
Dublin Core
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Title
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Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts.
Publisher
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Canadian journal of physiology and pharmacology
Date
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2014
2014-07
Subject
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*Cell Differentiation; Animals; Blood Glucose/metabolism; cardiac fibroblast; Cell Movement; Cell Proliferation; Cells; collagen; Collagen/metabolism; collagene; concentration elevee de glucose; Cultured; diabete; diabetes; fibroblaste cardiaque; Fibroblasts/*metabolism/pathology; Fibrosis; high glucose; Hyperglycemia/*metabolism/pathology; Male; migration; Myocardium/*metabolism/pathology; myofibroblast; myofibroblastes; proliferation; Rats; Signal Transduction; Sprague-Dawley
Creator
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Shamhart Patricia E; Luther Daniel J; Adapala Ravi K; Bryant Jennifer E; Petersen Kyle A; Meszaros J Gary; Thodeti Charles K
Description
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Diabetes is an independent risk factor for cardiovascular disease that can eventually cause cardiomyopathy and heart failure. Cardiac fibroblasts (CF) are the critical mediators of physiological and pathological cardiac remodeling; however, the effects of hyperglycemia on cardiac fibroblast function and differentiation is not well known. Here, we performed a comprehensive investigation on the effects of hyperglycemia on cardiac fibroblasts and show that hyperglycemia enhances cardiac fibroblast function and differentiation. We found that high glucose treatment increased collagen I, III, and VI gene expression in rat adult cardiac fibroblasts. Interestingly, hyperglycemia increased CF migration and proliferation that is augmented by collagen I and III. Surprisingly, we found that short term hyperglycemia transiently inhibited ERK1/2 activation but increased AKT phosphorylation. Finally, high glucose treatment increased spontaneous differentiation of cardiac fibroblasts to myofibroblasts with increasing passage compared with low glucose. Taken together, these findings suggest that hyperglycemia induces cardiac fibrosis by modulating collagen expression, migration, proliferation, and differentiation of cardiac fibroblasts.
Identifier
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<a href="http://doi.org/10.1139/cjpp-2013-0490" target="_blank" rel="noreferrer noopener">10.1139/cjpp-2013-0490</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cell Differentiation
2014
Adapala Ravi K
Animals
Blood Glucose/metabolism
Bryant Jennifer E
Canadian journal of physiology and pharmacology
cardiac fibroblast
Cell Movement
Cell Proliferation
Cells
Collagen
Collagen/metabolism
collagene
concentration elevee de glucose
Cultured
Department of Integrative Medical Sciences
diabete
Diabetes
fibroblaste cardiaque
Fibroblasts/*metabolism/pathology
Fibrosis
high glucose
Hyperglycemia/*metabolism/pathology
Luther Daniel J
Male
Meszaros J Gary
migration
Myocardium/*metabolism/pathology
myofibroblast
myofibroblastes
NEOMED College of Medicine
Petersen Kyle A
proliferation
Rats
Shamhart Patricia E
Signal Transduction
Sprague-Dawley
Thodeti Charles K