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Text
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URL Address
<a href="http://doi.org/10.1097/00007611-199108000-00017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00007611-199108000-00017</a>
Pages
1019–1022
Issue
8
Volume
84
Dublin Core
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Title
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Primary hyperparathyroidism and coexisting nephrogenic diabetes insipidus: rapid postoperative correction.
Publisher
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Southern medical journal
Date
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1991
1991-08
Subject
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Diabetes Insipidus/*complications/etiology; Humans; Hypercalcemia/complications; Hyperparathyroidism/*complications/surgery; Hypokalemia/complications; Male; Middle Aged
Creator
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Ellis G; Spirtos G; Polsky F
Description
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Shortly after diagnosis of primary hyperparathyroidism, a patient had serum hyperosmolality, polyuria, isosthenuria, profound potassium depletion, and elevated plasma antidiuretic hormone levels, all consistent with nephrogenic diabetes insipidus. After parathyroidectomy, serum calcium and serum osmolality levels fell concurrently. Profound potassium deficits did not recur. We propose that (1) hypercalcemia produced a concentrating defect and polyuria; (2) renal tubular acidosis and polyuria combined to produce severe potassium depletion; (3) hypokalemia potentiated the nephrogenic diabetes insipidus caused by hypercalcemia; and (4) postoperative disappearance of the diabetes insipidus confirmed its reversible, purely metabolic causes.
Identifier
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<a href="http://doi.org/10.1097/00007611-199108000-00017" target="_blank" rel="noreferrer noopener">10.1097/00007611-199108000-00017</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Diabetes Insipidus/*complications/etiology
Ellis G
Humans
Hypercalcemia/complications
Hyperparathyroidism/*complications/surgery
Hypokalemia/complications
Male
Middle Aged
Polsky F
Southern medical journal
Spirtos G