1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90494-e" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90494-e</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-4
Issue
1
Volume
134
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prolactin Stimulates Dopamine Release From The Rat Corpus Striatum In The Absence Of Extracellular Calcium
Publisher
An entity responsible for making the resource available
Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
amphetamine; behavior; binding-sites; brain; calcium; cerebrospinal-fluid; corpus striatum; dopamine; hypothalamus; in-vitro; Neurosciences & Neurology; prolactin; rat
Creator
An entity primarily responsible for making the resource
Laping N J; Dluzen D E; Ramirez V D
Description
An account of the resource
Prolactin (PRL) increased basal dopamine (DA) release and attenuated amphetamine (AMPH)-stimulated DA release in vitro from rat corpus striatum in a concentration-dependent manner with 10(-5) M PRL being the most effective. The effects of PRL on DA release were enhanced in the absence of extracellular calcium. PRL at 10(-5) M did not alter the DA post-superfusion content of the striatal tissue. These results indicate that the stimulatory effect of PRL on basal DA release does not require extra-cellular calcium and the inhibitory effect on AMPH-stimulated DA release is not due to depletion of DA stores.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90494-e" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90494-e</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
amphetamine
Behavior
binding-sites
Brain
calcium
cerebrospinal-fluid
corpus striatum
Dluzen D E
Dopamine
Hypothalamus
in-vitro
Journal Article or Conference Abstract Publication
Laping N J
Neuroscience letters
Neurosciences & Neurology
prolactin
Ramirez V D
rat
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90097-l" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90097-l</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
853-859
Issue
4
Volume
40
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Higher Alpha-noradrenergic Receptors In Paraventricular Nucleus Of Obese Zucker Rats - Decline After Food-deprivation
Publisher
An entity responsible for making the resource available
Pharmacology Biochemistry and Behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
adrenergic receptors; alpha-2-noradrenergic receptors; alpha-noradrenergic receptors; Behavioral Sciences; binding; brain-areas; circulating corticosterone; energy-expenditure; fa-fa; feeding behavior; feeding behavior; hypothalamic neuropeptide-y; hypothalamus; Neurosciences & Neurology; norepinephrine; obesity; paraventricular nucleus; Pharmacology & Pharmacy; zucker rats
Creator
An entity primarily responsible for making the resource
Jhanwaruniyal M; Awad I R; Gearhart G M; Finkelstein J A; Leibowitz S F
Description
An account of the resource
Norepinephrine (NE), acting through alpha-2-noradrenergic receptors in the hypothalamic paraventricular nucleus (PVN), has been implicated in the control of feeding behavior and body weight gain. To determine whether this hypothalamic receptor system is disturbed in genetically obese rats, the binding of radioligands to alpha-2-noradrenergic, as well as to alpha-1-noradrenergic, receptors was examined in seven hypothalamic nuclei of obese Zucker rats relative to their lean littermates. Receptor binding procedures, using the alpha-2-noradrenergic agonist [H-3]p-aminoclonidine ([H-3]PAC) and the alpha-1-noradrenergic antagonist [H-3]prazosin, demonstrated that the obese rats, compared to the lean rats, had significantly greater alpha-2-noradrenergic and alpha-1-noradrenergic receptor binding, specifically in the PVN as opposed to other hypothalamic areas examined. Moreover, the obese rats, compared to the lean rats, exhibited greater responsiveness to the effects of food deprivation (48 h), which caused a significant decline in radioligand binding to both alpha-2 and alpha-1 receptors, specifically in the PVN. A decrease in alpha-2-receptor binding after deprivation in the obese rats was also seen in two basal hypothalamic areas, namely, the supraoptic nucleus and arcuate nucleus-median eminence. The possibility exists that these disturbances in hypothalamic alpha-receptors may be involved in the development and/or maintenance of the genetic obesity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90097-l" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90097-l</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
adrenergic receptors
alpha-2-noradrenergic receptors
alpha-noradrenergic receptors
Awad I R
Behavioral Sciences
Binding
brain-areas
circulating corticosterone
energy-expenditure
fa-fa
Feeding Behavior
Finkelstein J A
Gearhart G M
hypothalamic neuropeptide-y
Hypothalamus
Jhanwaruniyal M
Journal Article or Conference Abstract Publication
Leibowitz S F
Neurosciences & Neurology
Norepinephrine
Obesity
paraventricular nucleus
Pharmacology & Pharmacy
Pharmacology Biochemistry and Behavior
zucker rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/en.131.2.964" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/en.131.2.964</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
964-969
Issue
2
Volume
131
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
QUANTIFICATION OF VASOACTIVE-INTESTINAL-PEPTIDE IMMUNOREACTIVITY IN THE ANTERIOR-PITUITARY GLANDS OF INTACT MALE AND FEMALE, OVARIECTOMIZED, AND ESTRADIOL BENZOATE-TREATED RATS
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-08
Subject
The topic of the resource
serotonin; expression; Endocrinology & Metabolism; estrogen; release; polypeptide; vip; hypothalamus; antisera; passive-immunization; prolactin secretion
Creator
An entity primarily responsible for making the resource
Carrillo A J; Phelps C J
Description
An account of the resource
There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies have generally failed to detect VIP-immunoreactive (IR) cells in the pituitary of the untreated rat, although VIP-IR cells have been observed in the pituitaries of hypothyroid or estrogen-treated rats. This study was designed to examine the cellular distribution and tissue content of VIP in the anterior pituitary gland of rats under selected endocrine conditions known to alter the rates of PRL and VIP synthesis and secretion. To this end, anterior pituitary VIP and PRL content (ICC and RIA) and serum PRL levels were determined in ovariectomized (OVX) and OVX rats 3 days after treatment with 7 or 70-mu-g estradiol benzoate (EB). For comparison, pituitary VIP and PRL content (ICC and RIA) and serum PRL levels in untreated male and diestrous female rats were determined. Immunostaining for VIP was accomplished using a newly developed primary antiserum. Significant numbers of VIP-IR cells per 5-mu-m section were found in the anterior pituitary glands of all animals examined (275 +/- 33 in diestrous to 481 +/- 103 cells in male rats). VIP was not colocalized with PRL in any of the pituitaries regardless of steroid treatment or sex. Furthermore, the number of VIP-IR cells per pituitary gland was not significantly correlated with sex or EB treatment. Treatment with 70-mu-g, but not 7-mu-g, EB significantly increased the pituitary content of VIP and serum PRL levels compared to those after ovariectomy. However, both EB treatments resulted in a significant increase in pituitary PRL content compared to that in untreated OVX rats. Pituitaries from male rats had several-fold more VIP and less PRL content than pituitaries from diestrous rats. These data show that 1) in contrast to previous ICC studies, VIP-IR cells are readily detected in the anterior pituitary of intact male and female and OVX as well as EB-treated rats; 2) VIP is localized to cells other than lactotrophs, regardless of the steroid background; and 3) marked changes in anterior pituitary VIP content are not accompanied by changes in VIP-IR cell number.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/en.131.2.964" target="_blank" rel="noreferrer noopener">10.1210/en.131.2.964</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
antisera
Carrillo A J
Endocrinology
Endocrinology & Metabolism
estrogen
expression
Hypothalamus
Journal Article or Conference Abstract Publication
passive-immunization
Phelps C J
polypeptide
prolactin secretion
release
serotonin
VIP
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0167-0115(91)90061-k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0167-0115(91)90061-k</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
263-270
Issue
2
Volume
36
Search for Full-text
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Dublin Core
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Title
A name given to the resource
ALTERATION OF SOMATOSTATIN BUT NOT GROWTH HORMONE-RELEASING FACTOR PITUITARY BINDING-SITES IN OBESE ZUCKER RATS
Publisher
An entity responsible for making the resource available
Regulatory Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
binding site; cells; defect; Endocrinology & Metabolism; growth hormone-releasing factor; hypothalamus; messenger-rna; Physiology; pituitary; secretion; somatostatin; tissue; zucker rat
Creator
An entity primarily responsible for making the resource
Abribat T; Finkelstein J A; Gaudreau P
Description
An account of the resource
The present study was designed to determine whether the diminution of growth hormone (GH) secretion that occurs in obese Zucker rats is related to alterations of GH-releasing factor (GRF) or somatostatin (SRIF) pituitary binding sites. Cold saturation studies were performed in pituitary homogenates of 4-month-old lean and obese rats, using [I-125-Tyr-10]hGRF(1-44)NH-2 as radioligand and [I-127-Tyr-10]hGRF-(1-44)NH-2 as competitor, and in pituitary membrane preparations, using [I-125-Tyr-0, D-Trp-8]SRIF14 as radioligand and [I-127-Tyr-0, D-Trp-8]SRIF14 as competitor. In lean rats, analysis of the curves by the Ligand program revealed the presence of two distinct classes of GRF binding sites, the first being of high affinity (0.74 +/- 0.11 nM) and low capacity (118 +/- 31 fmol/mg protein), the second being of lower affinity (880 +/- 240 nM) and higher capacity (140 +/- 35 pmol/mg protein), and of a single class of SRIF binding sites (affinity: 0.40 +/- 0.12 nM; capacity: 24 +/- 6 fmol/mg protein). In obese rats, no difference was observed in GRF binding parameters for both classes of sites, but the concentration of somatostatin binding sites was reduced by 67% when compared to their lean littermates. These findings suggest that the SRIF pituitary receptors are down-regulated in obese Zucker rats and indicate that no alteration of GRF pituitary binding sites contribute to the blunted GH secretion observed in this model of obesity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0167-0115(91)90061-k" target="_blank" rel="noreferrer noopener">10.1016/0167-0115(91)90061-k</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Abribat T
binding site
Cells
defect
Endocrinology & Metabolism
Finkelstein J A
Gaudreau P
growth hormone-releasing factor
Hypothalamus
Journal Article or Conference Abstract Publication
messenger-rna
Physiology
pituitary
Regulatory Peptides
secretion
somatostatin
tissue
zucker rat
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(92)91238-a" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(92)91238-a</a>
Pages
367–371
Issue
1
Volume
585
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
*Sex Characteristics; Animals; Catecholamines/*metabolism; Female; Hypothalamus; Inbred Strains; Male; Mice; Middle/*metabolism; Olfactory Bulb/*metabolism; Sexual Maturation/*physiology; Urine/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen D; Guan X; Vandenbergh J G
Description
An account of the resource
In the present experiment peri-pubertal female mice were treated with a partially purified puberty accelerating urine extract (PAUE). Mice treated with the PAUE showed an advance in the onset of puberty as indicated by significantly increased uterine weights. Treatment with the PAUE did not alter basal or potassium- (K+, 30 mM) stimulated release of catecholamines (dopamine or norepinephrine) from either anterior or posterior superfused olfactory bulb tissue fragments. There was, however, an overall significantly greater amount of basal and K(+)-stimulated release of NE from the posterior vs. the anterior olfactory bulb. Potassium-stimulated-, but not basal, release of catecholamines from the medial basal hypothalamus of PAUE-treated female mice were increased, with dopamine showing a statistically significant difference compared to water-treated females. These data demonstrate that treatment with the PAUE is a very effective means to accelerate the onset of puberty and results in accompanying increases in catecholaminergic activity, in particular dopamine, within the medial basal hypothalamus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(92)91238-a" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(92)91238-a</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1992
Animals
Brain research
Catecholamines/*metabolism
Dluzen D
Female
Guan X
Hypothalamus
Inbred Strains
Male
Mice
Middle/*metabolism
Olfactory Bulb/*metabolism
Sexual Maturation/*physiology
Urine/*physiology
Vandenbergh J G