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Text
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URL Address
<a href="http://doi.org/10.5863/1551-6776-26.2.115" target="_blank" rel="noreferrer noopener">http://doi.org/10.5863/1551-6776-26.2.115</a>
Pages
115-122
Issue
2
Volume
26
ISSN
15516776
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.5863/1551-6776-26.2.115" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.5863/1551-6776-26.2.115</a>
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Update Year & Number
April 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pharmacy Practice
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Title
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Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.
Publisher
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Journal Of Pediatric Pharmacology & Therapeutics
Date
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2021
2021-02
Subject
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amphotericin B; antifungal agents; Candida; candidiasis; DENTAL prophylaxis; fluconazole; FLUCONAZOLE; INVASIVE candidiasis; NEONATAL intensive care units; newborn; pharmacokinetics; PHARMACOKINETICS; PREMATURE infants
Creator
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Hornik CD; Bondi DS; Greene NM; Cober MP; John B
Description
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Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of America provides guidelines on antifungal medications for the prophylaxis and treatment of candidiasis in NICUs; however, there are still variations in practice on the use of fluconazole for prophylaxis and treatment of invasive candidiasis. This review provides specific information regarding fluconazole activity, pharmacokinetics, and a literature evaluation of dosing strategies and comparisons to other treatments in the neonatal population. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.5863/1551-6776-26.2.115" target="_blank" rel="noreferrer noopener">10.5863/1551-6776-26.2.115</a>
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journalArticle
2021
amphotericin B
ANTIFUNGAL agents
April 2021 List
Bondi DS
Candida
Candidiasis
Cober MP
DENTAL prophylaxis
Department of Pharmacy Practice
fluconazole
Greene NM
Hornik CD
INVASIVE candidiasis
John B
Journal Of Pediatric Pharmacology & Therapeutics
journalArticle
NEOMED College of Medicine
NEONATAL intensive care units
Newborn
pharmacokinetics
PREMATURE infants