1
40
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Text
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URL Address
<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2014.00051</a>
Pages
51–51
Volume
8
Dublin Core
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Title
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Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.
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Frontiers in neural circuits
Date
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2014
1905-07
Subject
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Animals; IPSC; Chick Embryo; Patch-Clamp Techniques; Neurons/*physiology; Auditory Pathways/*physiology; GABAergic inhibition; Inhibitory Postsynaptic Potentials/*physiology; interaural time difference; IPSP; Sound Localization/physiology; Synaptic Transmission/*physiology; tonotopy; voltage-gated low-threshold potassium current; whole-cell patch; Potassium Channels; Voltage-Gated/*physiology
Creator
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Hamlet William R; Liu Yu-Wei; Tang Zheng-Quan; Lu Yong
Description
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Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between intrinsic voltage-gated conductances and extrinsic synaptic conductances in determining neuronal output are not well understood. In chicken, neurons in the nucleus laminaris (NL) encode sound location using interaural time difference (ITD) as a cue. Along the tonotopic axis of NL, there exist robust differences among low, middle, and high frequency (LF, MF, and HF, respectively) neurons in a variety of neuronal properties such as low threshold voltage-gated K(+) (LTK) channels and depolarizing inhibition. This establishes NL as an ideal model to examine the interactions between LTK currents and synaptic inhibition across the tonotopic axis. Using whole-cell patch clamp recordings prepared from chicken embryos (E17-E18), we found that LTK currents were larger in MF and HF neurons than in LF neurons. Kinetic analysis revealed that LTK currents in MF neurons activated at lower voltages than in LF and HF neurons, whereas the inactivation of the currents was similar across the tonotopic axis. Surprisingly, blockade of LTK currents using dendrotoxin-I (DTX) tended to broaden the duration and increase the amplitude of the depolarizing inhibitory postsynaptic potentials (IPSPs) in NL neurons without dependence on coding frequency regions. Analyses of the effects of DTX on inhibitory postsynaptic currents led us to interpret this unexpected observation as a result of primarily postsynaptic effects of LTK currents on MF and HF neurons, and combined presynaptic and postsynaptic effects in LF neurons. Furthermore, DTX transferred subthreshold IPSPs to spikes. Taken together, the results suggest a critical role for LTK currents in regulating inhibitory synaptic strength in ITD-coding neurons at various frequencies.
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<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">10.3389/fncir.2014.00051</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Auditory Pathways/*physiology
Chick Embryo
Department of Anatomy & Neurobiology
Frontiers in neural circuits
GABAergic inhibition
Hamlet William R
Inhibitory Postsynaptic Potentials/*physiology
interaural time difference
IPSC
IPSP
Liu Yu-Wei
Lu Yong
NEOMED College of Medicine
Neurons/*physiology
Patch-Clamp Techniques
Potassium Channels
Sound Localization/physiology
Synaptic Transmission/*physiology
Tang Zheng-Quan
tonotopy
voltage-gated low-threshold potassium current
Voltage-Gated/*physiology
whole-cell patch
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2009.11.070" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2009.11.070</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1490-1500
Issue
4
Volume
165
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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SUPPRESSION OF SPONTANEOUS FIRING IN INFERIOR COLLICULUS NEURONS DURING SOUND PROCESSING
Publisher
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Neuroscience
Date
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2010
2010-02
Subject
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auditory-nerve fibers; awake animal; awake bats; bat; crossed olivocochlear bundle; electrical-stimulation; frequency modulated sweep; guinea-pigs; hair-cells; intracellular recording; intracellular-recordings; IPSP; Neurosciences & Neurology; nucleus; postsynaptic potentials; signal-to-noise ratio; somatosensory systems; ventral cochlear
Creator
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Voytenko S V; Galazyuk A V
Description
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Spontaneous activity is a well-known neural phenomenon that occurs throughout the brain and is essential for normal development of auditory circuits and for processing of sounds. Spontaneous activity could interfere with sound processing by reducing the signal-to-noise ratio. Multiple studies have reported that spontaneous activity in auditory neurons can be suppressed by sound stimuli. The goal of this study was to determine the stimulus conditions that cause this suppression and to identify possible underlying mechanisms. Experiments were conducted in the inferior colliculus (IC) of awake little brown bats using extracellular and intracellular recording techniques. The majority of IC neurons (82%) fired spontaneously, with a median spontaneous firing rate of 6 spikes/s. After offset of a 4 ms sound, more than half of these neurons exhibited suppression of spontaneous firing that lasted hundreds of milliseconds. The duration of suppression increased with sound level. Intracellular recordings showed that a short (<50 ms) membrane hyperpolarization was often present during the beginning of suppression, but it was never observed during the remainder of the suppression. Beyond the initial 50 ms period, the absence of significant changes in input resistance during suppression suggests that suppression is presynaptic in origin. Namely, it may occur on presynaptic terminals and/or elsewhere on presynaptic neurons. Suppression of spontaneous firing may serve as a mechanism for enhancing signal-to-noise ratios during signal processing. Published by Elsevier Ltd on behalf of IBRO.
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<a href="http://doi.org/10.1016/j.neuroscience.2009.11.070" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2009.11.070</a>
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Journal Article
2010
auditory-nerve fibers
awake animal
awake bats
bat
crossed olivocochlear bundle
electrical-stimulation
frequency modulated sweep
Galazyuk A V
guinea-pigs
hair-cells
intracellular recording
intracellular-recordings
IPSP
Journal Article
Neuroscience
Neurosciences & Neurology
nucleus
postsynaptic potentials
Signal-To-Noise Ratio
somatosensory systems
ventral cochlear
Voytenko S V