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Text
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acschembio.0c00380</a>
ISSN
1554-8937
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Update Year & Number
September 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
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Title
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Examining targeted protein degradation from physiological and analytical perspectives: Enabling translation between cells and subjects.
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ACS Chemical Biology
Date
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2020
2020-09-30
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Daurio NA;Zhou H;Chen Y;Sheth PR;Imbriglio JE;McLaren DG;Tawa P;Rachdaoui N;Previs MJ;Kasumov T;O'Neil J;Previs SF
Description
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The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to generate proteolysis targeting chimeras (bifunctional molecules, also referred to as PROTACS) or "molecular glues" to accelerate protein degradation, we suspect that investigations could also benefit by directing attention toward physiological regulation surrounding protein homeostasis, including the methods that can be used to examine changes in protein kinetics. This perspective will first consider some metabolic scenarios that might be of importance when one aims to change protein abundance by increasing protein degradation. Specifically, could protein turnover impact the apparent outcome? We will then outline how to study protein dynamics by coupling stable isotope tracer methods with mass spectrometry-based detection; since the experimental conditions could have a dramatic effect on protein turnover, special attention is directed toward the application of methods for quantifying protein kinetics using in vitro and in vivo models. Our goal is to present key concepts that should enable mechanistically informed studies which test targeted protein degradation strategies.
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">10.1021/acschembio.0c00380</a>
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journalArticle
2020
Acs Chemical Biology
Chen Y
Daurio NA
Department of Pharmaceutical Sciences
Imbriglio JE
journalArticle
Kasumov T
McLaren DG
NEOMED College of Pharmacy
O'Neil J
Previs MJ
Previs SF
Rachdaoui N
September 2020 List
Sheth PR
Tawa P
Zhou H