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Text
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URL Address
<a href="http://doi.org/10.1016/j.bmcl.2012.06.096" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2012.06.096</a>
Pages
5675–5678
Issue
17
Volume
22
Dublin Core
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Title
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Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Publisher
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Bioorganic & medicinal chemistry letters
Date
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2012
2012-09
Subject
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Binding Sites; Drug Discovery; Humans; Immediate-Early Proteins/*antagonists & inhibitors/chemistry/metabolism; Ligands; Molecular Docking Simulation; Protein Kinase Inhibitors/*chemistry/*pharmacology; Protein-Serine-Threonine Kinases/*antagonists & inhibitors/chemistry/metabolism
Creator
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Geldenhuys Werner J; Talasila Phani K; Sadana Prabodh
Description
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The serum and glucocorticoid regulated kinase-1 (SGK1) is part of the serine/threonine kinase family and has therapeutic potential in several neurodegenerative diseases such as ischemic stroke and Parkinson's disease. Here we use structure-based virtual screening to identify a novel ligand which inhibits SGK1 activity. The data presented here can be used for future scaffold hopping and possible drug development efforts.
Identifier
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<a href="http://doi.org/10.1016/j.bmcl.2012.06.096" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2012.06.096</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Binding Sites
Bioorganic & medicinal chemistry letters
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug Discovery
Geldenhuys Werner J
Humans
Immediate-Early Proteins/*antagonists & inhibitors/chemistry/metabolism
Ligands
Molecular Docking Simulation
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Protein Kinase Inhibitors/*chemistry/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors/chemistry/metabolism
Sadana Prabodh
Talasila Phani K