Description
We tested the hypothesis that interleukin (IL)-1beta-induced cortisol synthesis stimulates distal lung fluid absorption in fetal guinea pigs via induction of serum- and glucocorticoid-regulated kinase (SGK) and inhibition of neural precursor cell expressed, developmentally downregulated protein 4-2 (Nedd4-2).
Subject
Absorption/drug effects; Animals; Base Sequence; Body Fluids/metabolism; DNA/genetics; Endosomal Sorting Complexes Required for Transport; Epithelial Sodium Channels/metabolism; Female; Guinea Pigs; Hydrocortisone/*biosynthesis/blood/physiology; Immediate-Early Proteins/genetics/*metabolism; Interleukin-1beta/*pharmacology; Lung/*drug effects/*physiology; Molecular Sequence Data; Nedd4 Ubiquitin Protein Ligases; Pregnancy; Protein-Serine-Threonine Kinases/genetics/*metabolism; Recombinant Proteins/pharmacology; Ubiquitin-Protein Ligases/*antagonists & inhibitors/genetics