Browse Items · NEOMED Bibliography Database

A second generation leishmanization vaccine with a markerless attenuated leishmania major strain using CRISPR gene editing

Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted…

The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications.

Parasitic infections pose a wide and varying threat globally, impacting over 25% of the global population with many more at risk of infection. These infections are comprised of, but not limited to, toxoplasmosis, malaria, leishmaniasis and any one…

Serine Proteases in Systemic Lupus Erythematosus: The Other Half of the Story.

Tags: 2016, Female, Humans, Immunity, Immunity – Immunology, Innate/*immunology, Lupus Erythematosus, Mannose-Binding Lectin/*metabolism, Mannose-Binding Protein-Associated Serine Proteases/*metabolism, Proteins – Metabolism, Rothschild Bruce, Systemic – Immunology, Systemic – Physiopathology, Systemic/*immunology/*physiopathology, The Journal of rheumatology

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses.

The development of novel immune adjuvants is emerging as a significant area of vaccine delivery based on the continued necessity to amplify immune responses to a wide array of new antigens that are poorly immunogenic. This article specifically…

Tags: *Microspheres, *Nanoparticles, 2010, Adaptive Immunity, Adjuvants, Animals, Cui Zhengrong, Department of Pharmaceutical Sciences, Expert review of vaccines, Humans, Immunity, Immunologic/*pharmacology, Innate, Kumar Amit, NEOMED College of Pharmacy, Oyewumi Moses O, Particle Size, Vaccines/*immunology

Alterations in gene array patterns in dendritic cells from aged humans.

Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age.…

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq…

An update on the association of vitamin D deficiency with common infectious diseases.

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body…

Putting chemical and environmental sensitivities in perspective.

Chemical sensitivity has been recognized for an extended period. Over the last 30 years or more, there has been a growing number of chemicals to which humans are being exposed. Some people have become sensitive to one or more of these chemicals and…

Tags: 1998, Allergens/immunology, Cellular/immunology, Environmental Exposure, Environmental Illness/*diagnosis/immunology/physiopathology/therapy, Food Hypersensitivity/diagnosis, Humans, Hypersensitivity, Hypersensitivity/diagnosis/therapy, Immediate/immunology, Immunity, Incidence, Multiple Chemical Sensitivity/*diagnosis/immunology/physiopathology/therapy, Otolaryngologic clinics of North America, Otorhinolaryngologic Diseases/diagnosis/immunology/therapy, Physical Examination, Vojdani A, Waickman F J

Immunopathogenesis of osteoarthritis.

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors…

Tags: 2013, Adaptive Immunity, Animals, Clinical immunology (Orlando, Fla.), Department of Anatomy & Neurobiology, Haqqi Tariq M, Haseeb Abdul, Humans, Immunity, Innate, NEOMED College of Medicine, Osteoarthritis/*immunology, Signal Transduction

Mice transgenic for simian immunodeficiency virus nef are immunologically compromised.

An intact nef gene is essential for rapid development of immunodeficiency in human immunodeficiency virus and simian immunodeficiency virus infections. To assess the role of nef in the immune response, mice transgenic for SIV nef were constructed and…

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