Browse Items · NEOMED Bibliography Database

Painful Cutaneous Nodule of the Jawline.

Tags: 2016, Adult, Biopsy, Cernik Christina, Department of Internal Medicine, Diagnosis, Differential, Facial Dermatoses – Diagnosis, Facial Dermatoses – Pathology, Facial Dermatoses/diagnosis/pathology, Female, Hereditary – Diagnosis, Hereditary – Pathology, Hereditary/diagnosis/*pathology, Humans, Immunohistochemistry, JAMA dermatology, Kunzler Elaine, Leiomyoma – Diagnosis, Leiomyoma – Pathology, Leiomyomatosis/diagnosis/*pathology, Neck – Pathology, Neck/pathology, Needle, NEOMED College of Medicine, Neoplastic Syndromes, Skin Abnormalities – Diagnosis, Skin Abnormalities – Pathology, Skin Abnormalities/diagnosis/*pathology, Skin Neoplasms – Diagnosis, Skin Neoplasms – Pathology, Skin Neoplasms/diagnosis/*pathology, Uterine Neoplasms – Diagnosis, Uterine Neoplasms – Pathology, Uterine Neoplasms/diagnosis/*pathology, Weaver Joshua

MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

OBJECTIVE: Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1beta (IL-1beta) has been implicated as a principal instigator of OA, we sought to determine whether

Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western

Immunohistochemical localization of serotoninergic, enkephalinergic, and catecholaminergic cells in the brainstem and diencephalon of a cartilaginous fish, Hydrolagus colliei.

We localized serotonin (5-HT), leu-enkephalin (LENK), and tyrosine hydroxylase (TH) immunoreactive cells in the brain of a holocephalian, Hydrolagus colliei, by use of antibodies made in rabbit and the peroxidase-antiperoxidase technique. Only three…

Tags: 1991, Animals, Brain Stem/cytology/*metabolism, Catecholamines/*metabolism, Cruce W L, Diencephalon/cytology/*metabolism, Enkephalins/*metabolism, Female, Fishes/*metabolism, Immunohistochemistry, Male, Neurons/metabolism, Serotonin/*metabolism, Stuesse S L, The Journal of comparative neurology, Tissue Distribution

Raphe nuclei in three cartilaginous fishes, Hydrolagus colliei, Heterodontus francisci, and Squalus acanthias.

The vertebrate reticular formation, containing over 30 nuclei in mammals, is a core brainstem area with a long evolutionary history. However, not all reticular nuclei are equally old. Nuclei that are widespread among the vertebrate classes are…

Tags: *Biological Evolution, 1995, Animals, Cruce W L, Dogfish/*anatomy & histology/metabolism, Elasmobranchii/*anatomy & histology/metabolism, Enkephalin, Immunohistochemistry, Leucine/analysis, Raphe Nuclei/*anatomy & histology/chemistry, Serotonin/analysis, Sharks/*anatomy & histology/metabolism, Stuesse D C, Stuesse S L, The Journal of comparative neurology

Images in cytology. Fine-needle aspiration of a lumbar chordoma.

Tags: 2010, Biopsy, Chordoma/diagnosis/*pathology, Diagnosis, Diagnostic cytopathology, Differential, Female, Fine-Needle, Ganesan Santhi, Humans, Immunohistochemistry, Lumbar Vertebrae/*pathology, Middle Aged, Moonda Afreen H

Immunohistochemical distribution of enkephalin, substance P, and somatostatin in the brainstem of the leopard frog, Rana pipiens.

The brainstems of frogs contain many of the neurochemicals that are found in mammals. However, the clustering of nuclei near the ventricles makes it difficult to distinguish individual cell groups. We addressed this problem by combining…

Tags: *Stilbamidines, 2001, Adli D S, Animals, Brain Stem/*chemistry/cytology, Cruce W L, Enkephalins/*analysis, Fluorescent Dyes, Immunohistochemistry, Male, Microscopy research and technique, Rana pipiens/*metabolism, Somatostatin/*analysis, Spinal Cord/chemistry/cytology, Stuesse S L, Substance P/*analysis

Distribution and origin of corticotropin-releasing factor-immunoreactive axons in the female rat lumbosacral spinal cord.

Corticotropin-releasing factor (CRF) is a neuropeptide traditionally known for its hormonal role in the hypothalamic/pituitary/adrenal stress axis. However, CRF has been reported in axons in sites that may be considered outside of the direct stress…

Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.

Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of…

Hypothalamic paraventricular axons projecting to the female rat lumbosacral spinal cord contain oxytocin immunoreactivity.

Oxytocin-containing axons project from the hypothalamic paraventricular nucleus to the neurohypophysis and thoracic spinal cord to ultimately influence uterine contractions and autonomic activity, respectively. Whether or not oxytocin-immunoreactive…

Tags: *Synaptic Transmission, 2001, Animals, Axons/*physiology, Female, Immunohistochemistry, Journal of neuroscience research, Lumbosacral Region, Nerve Fibers/metabolism/physiology, Oxytocin/*metabolism, Papka R E, Paraventricular Hypothalamic Nucleus/*physiology, Puder B A, Rats, Spinal Cord/*physiology, Sprague-Dawley

Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.

During corneal development, neural crest derivatives from the periocular mesenchyme migrate into the cornea and differentiate into corneal fibroblasts. During this time, these cells interact with a variety of extracellular matrices for proper…

Immunohistochemical localization of serotonin, leu-enkephalin, tyrosine hydroxylase, and substance P within the visceral sensory area of cartilaginous fish.

We examined the distribution of immunoreactivity to serotonin (5-HT), leu-enkephalin (LENK), tyrosine-hydroxylase (TH), and substance P (SP) within the primary visceral sensory region of cartilaginous fish. Two genera of sharks, Squalus and…

Tags: *Brain Chemistry, 1992, Animals, Antibodies, Brain Stem/cytology, Cell and tissue research, Cruce W L, Enkephalin, Fishes, Immunohistochemistry, Leucine/*analysis, Medulla Oblongata/cytology, Serotonin/*analysis, Stuesse D C, Stuesse S L, Substance P/*analysis, Tyrosine 3-Monooxygenase/*analysis

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.

ATP, an intracellular energy source, is released from cells during tissue stress, damage, or inflammation. The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral…

Vagal afferents from the uterus and cervix provide direct connections to the brainstem.

Previous anatomical studies demonstrated vagal innervation to the ovary and distal colon and suggested the vagus nerve has uterine inputs. Recent behavioral and physiological evidence indicated that the vagus nerves conduct sensory information from…

Tags: 1999, Animals, Berthoud H R, Brain Stem/*anatomy & histology, Cell and tissue research, Cervix Uteri/*innervation, Collins J J, Estrogen/metabolism, Female, Immunohistochemistry, Lin C E, Neurons/cytology/metabolism, Papka R E, Rats, Receptors, Sprague-Dawley, Uterus/*innervation, Vagus Nerve/*anatomy & histology/metabolism

Calretinin-immunoreactive nerves in the uterus, pelvic autonomic ganglia, lumbosacral dorsal root ganglia and lumbosacral spinal cord.

Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin…

Projections from auditory cortex to cholinergic cells in the midbrain tegmentum of guinea pigs.

Anterograde and retrograde tracing techniques were used to characterize projections from the auditory cortex to the pedunculopontine and laterodorsal tegmental nuclei (PPT and LDT, respectively) in the midbrain tegmentum in guinea pigs. For…

Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.

Hepatocellular carcinoma (HCC) is one of the most common cancers and lethal diseases. In view of the limited treatment and a grave prognosis of liver cancer, preventive control has been emphasized. Resveratrol, a polyphenol found in grape skins,…

Detection of single mRNAs in individual cells of the auditory system.

Gene expression analysis is essential for understanding the rich repertoire of cellular functions. With the development of sensitive molecular tools such as single-cell RNA sequencing, extensive gene expression data can be obtained and analyzed from…

Spreading pigmented actinic keratosis: a review.

INTRODUCTION: Spreading pigmented actinic keratosis (SPAK) is a common, but uncommonly reported or appreciated, variant of classic actinic keratosis (AK). It can mimic different pigmented lesions, which may be benign (eg, solar lentigo) or malignant…

Pilomatricoma of the upper arm in an orthopaedic clinic.

Sources of cholinergic input to the inferior colliculus.

We combined retrograde tracing with immunohistochemistry for choline acetyltransferase to identify the source of cholinergic input to the inferior colliculus (IC) in guinea pigs. Injection of a retrograde tracer into one IC labeled cells in many…

Tags: 2009, Acetylcholine/*metabolism, Animals, Choline O-Acetyltransferase/metabolism, Department of Anatomy & Neurobiology, Female, Guinea Pigs, Immunohistochemistry, Inferior Colliculi/*anatomy & histology, Male, Motts S D, NEOMED College of Medicine, Neural Pathways/anatomy & histology/metabolism, Neuroscience, Pedunculopontine Tegmental Nucleus/anatomy & histology/metabolism, Photomicrography, Schofield B R, Tegmentum Mesencephali/*anatomy & histology/*metabolism

Projections from auditory cortex to midbrain cholinergic neurons that project to the inferior colliculus.

We have shown that auditory cortex projects to cholinergic cells in the pedunculopontine tegmental nucleus (PPT) and laterodorsal tegmental nucleus (LDT). PPT and LDT are the sources of cholinergic projections to the inferior colliculus, but it is…

Cholinergic cells in the tegmentum send branching projections to the inferior colliculus and the medial geniculate body.

The pontomesencephalic tegmentum (PMT) provides cholinergic input to the inferior colliculus (IC) and the medial geniculate body (MG). PMT cells are often characterized as projecting to more than one target. The purpose of this study was to determine…

Tags: 2011, Acetylcholine/metabolism, Animals, Auditory Pathways/*cytology, Department of Anatomy & Neurobiology, Female, Geniculate Bodies/*cytology, Guinea Pigs, Immunohistochemistry, Inferior Colliculi/*cytology, Male, Motts S D, NEOMED College of Medicine, Neurons/*cytology/metabolism, Neuroscience, Schofield B R, Tegmentum Mesencephali/*cytology

Multiple origins of cholinergic innervation of the cochlear nucleus.

Acetylcholine (Ach) affects a variety of cell types in the cochlear nucleus (CN) and is likely to play a role in numerous functions. Previous work in rats suggested that the acetylcholine arises from cells in the superior olivary complex, including…

Tags: *Cholinergic Fibers, 2011, Acetylcholine/metabolism, Animals, Auditory Pathways/*cytology/metabolism, Cochlear Nucleus/*anatomy & histology/metabolism, Department of Anatomy & Neurobiology, Guinea Pigs, Immunohistochemistry, Mellott J G, Motts S D, NEOMED College of Medicine, Neuroscience, Schofield B R

The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord.

Before parturition the uterine cervix undergoes a ripening process ("softens" and dilates) to allow passage of the fetus at term. The exact mechanism(s) responsible for cervical ripening are unknown, though a role for peptidergic sensory neurons is…

Sensory nerves and neuropeptides in uterine cervical ripening.

At the time of parturition (fetal delivery) the uterine cervix must "ripen," becoming soft, pliable, and dilated to accommodate the fetus' delivery. The fundamental processes underlying cervical ripening remain poorly understood. Knowledge that…

Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.

Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence…

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.

Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of…

Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.

Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases…

Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.

Traumatic brain injury (TBI) has acute and chronic sequelae, including an increased risk for the development of Alzheimer's disease (AD). TBI-associated neuroinflammation is characterized by activation of brain-resident microglia and infiltration of…

Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses.

Osteoarthritis (OA) is a prevalent age-associated disease involving altered chondrocyte homeostasis and cartilage degeneration. The avascular nature of cartilage and the altered chondrocyte phenotype characteristic of OA severely limit the capacity…

Melanotic schwannoma. An unusual case of an ossified soft tissue mass.

A case of a melanotic schwannoma presenting as a soft tissue mass of the abductors of the hip is reported. The radiographic findings suggested myositis ossificans, but several subtle findings raised the concern for something else. A bilobed…

Gastric Lipoma: A Review of the Literature.

Gastric lipoma is a rare benign tumor of the stomach. The imaging characteristics are diagnostic because the lesion has fat attenuation on computed tomography and demonstrates characteristics of fat on magnetic resonance images. On ultrasound, the…

Real-time ultrasound elasticity of the breast: initial clinical results.

PURPOSE: To determine the sensitivity and specificity of a real-time elasticity imaging (EI) ultrasound (US) system in the characterization of breast lesions as benign or malignant. METHODS: A total of 208 patients with 251 lesions were scheduled to…

Iron localization in superficial siderosis of the central nervous system.

Originally conceived as an uncommon disorder, with the advent of MRI, CNS superficial siderosis has been observed more frequently. We present histologic, histochemical, immunohistochemical, immunofluorescent and ultrastructural evaluation of a…

Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary glands of intact male and female, ovariectomized, and estradiol benzoate-treated rats.

There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies…

Tags: *Ovariectomy, 1992, Animals, Anterior/*chemistry/drug effects/metabolism, Carrillo A J, Diestrus, Endocrinology, Estradiol/*pharmacology, Female, Immunohistochemistry, Inbred Strains, Male, Phelps C J, Pituitary Gland, Prolactin/blood/metabolism, Rats, Vasoactive Intestinal Peptide/*analysis/metabolism

Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening.

Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in…

Tags: 2004, Animal/*metabolism, Animals, Cervical Ripening/*metabolism, Cervix Uteri/blood supply/innervation/*metabolism, Denervation, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Hattori Y, Immunohistochemistry, Jesmin S, Microcirculation, Mowa C N, NEOMED College of Medicine, Nitric Oxide Synthase Type III, Nitric Oxide Synthase/biosynthesis, Papka R, Phosphorylation, Pregnancy, Protein Isoforms/biosynthesis/metabolism, Protein-Serine-Threonine Kinases/biosynthesis, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/biosynthesis, Rats, Reverse Transcriptase Polymerase Chain Reaction, Sakuma I, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Togashi H, Usip S, Vascular Endothelial Growth Factor A/biosynthesis/*metabolism, Vascular Endothelial Growth Factor Receptor-2/biosynthesis, Wistar, Yoshioka M

Focal ellipsoid deposits in the atrial myocytes of Syrian hamster.

A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been…

Tags: 1994, Animals, Cricetinae, Female, Gilloteaux J, Heart Atria/metabolism/*ultrastructure, Immunoelectron, Immunohistochemistry, Inclusion Bodies/metabolism/*ultrastructure, Jennes L, Male, Mesocricetus, Microscopy, Stoeckel M E, Ultrastructural pathology, Vanderhaeghen J J

Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kappaB and Nrf2 signaling pathways.

Trianthema portulacastrum, a medicinal and dietary plant, has gained substantial importance due to its various pharmacological properties, including anti-inflammatory and anticarcinogenic activities. We have recently reported that a characterized T.…

Contributions of paleorheumatology to understanding contemporary disease.

As paleopathology has evolved from observational speculation to analysis of testable hypotheses, so too has recognition of its contribution to vertebrate paleontology. In the presence of significant structural and density variation (between matrix…

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