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40
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Text
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URL Address
<a href="http://doi.org/10.12659/AOT.909781" target="_blank" rel="noreferrer noopener">http://doi.org/10.12659/AOT.909781</a>
Pages
631–638
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of Immunosuppressive Therapy on the Occurrence of Atypical Hemolytic Uremic Syndrome in Renal Transplant Recipients.
Publisher
An entity responsible for making the resource available
Annals of transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-09
Subject
The topic of the resource
Adult; Female; Humans; Male; Middle Aged; Adrenal Cortex Hormones/adverse effects; Atypical Hemolytic Uremic Syndrome/*epidemiology/etiology; Immunosuppression/adverse effects; Immunosuppressive Agents/*adverse effects; Incidence; Kidney Transplantation/*adverse effects; Postoperative Complications/*epidemiology/etiology; Retrospective Studies; Sirolimus/adverse effects; Transplant Recipients; Kidney Failure; Chronic/*surgery
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Chauvin Abigail; Fox Kelli; Kesav Natasha; Ascha Mustafa S; Vachharajani Tushar J; Krishnappa Vinod
Description
An account of the resource
BACKGROUND Atypical hemolytic uremic syndrome (aHUS), a rare thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Caused by genetic mutations in the alternative complement cascade, aHUS often will culminate in end-stage renal disease and occasionally death. Renal transplantation in aHUS patients has been contraindicated in the past due to the recurrence risk, with certain immunosuppressive regimens being commonly attributed. In this study, we analyzed the association between aHUS and immunosuppressive agents so as to offer evidence for the use of certain immunosuppressive regimens in renal transplant recipients. MATERIAL AND METHODS Our study is a retrospective analysis using data from the United States Renal Data System from 2004 to 2012. A cohort of renal transplantation patients diagnosed with aHUS were identified to include in the study. The primary endpoint was the determination of aHUS incidence in renal transplant recipients due to various immunosuppressive agents. The secondary endpoints were to check the relationship between the drug type as well as the demographic variables that increase the risk for aHUS. RESULTS It was found that there was a higher usage of sirolimus (P=0.015) and corticosteroids (P=0.030) in the aHUS patients compared to patients in other diagnoses group. CONCLUSIONS There was a higher usage of sirolimus and corticosteroids in renal transplantation patients diagnosed with aHUS. Unfortunately, due to the rarity of this disease, the sample size was small (n=14). Despite the small sample size, this data analysis throws light on the relationship between aHUS and immunosuppressive agents in renal transplant recipients, although we still have much to learn.
Identifier
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<a href="http://doi.org/10.12659/AOT.909781" target="_blank" rel="noreferrer noopener">10.12659/AOT.909781</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Adrenal Cortex Hormones/adverse effects
Adult
Annals of transplantation
Ascha Mustafa S
Atypical Hemolytic Uremic Syndrome/*epidemiology/etiology
Chauvin Abigail
Chronic/*surgery
Department of Internal Medicine
Female
Fox Kelli
Humans
Immunosuppression/adverse effects
Immunosuppressive Agents/*adverse effects
Incidence
Kesav Natasha
Kidney Failure
Kidney Transplantation/*adverse effects
Krishnappa Vinod
Male
Middle Aged
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Postoperative Complications/*epidemiology/etiology
Raina Rupesh
Retrospective Studies
Sirolimus/adverse effects
Transplant Recipients
Vachharajani Tushar J
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
273–274
Issue
3
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cutaneous effects of sirolimus in renal transplant recipients.
Publisher
An entity responsible for making the resource available
Journal of drugs in dermatology : JDD
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-03
Subject
The topic of the resource
Humans; Immunosuppressive Agents/*adverse effects; *Kidney Transplantation; Drug Eruptions/*etiology; Sirolimus/*adverse effects
Creator
An entity primarily responsible for making the resource
Warino Lindsey; Libecco James
Description
An account of the resource
Cancer is a major cause of death in immunosuppressed transplant patients. Therefore, sirolimus is frequently used in these patients for its immunosuppressive and antineoplastic properties. However, a variety of cutaneous side effects have resulted from sirolimus therapy. Consequently, dermatologists must be aware of such adverse events and understand the risks and benefits of discontinuing therapy.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Kidney Transplantation
2006
Department of Family & Community Medicine
Department of Internal Medicine
Drug Eruptions/*etiology
Humans
Immunosuppressive Agents/*adverse effects
Journal of drugs in dermatology : JDD
Libecco James
NEOMED College of Medicine
Sirolimus/*adverse effects
Warino Lindsey