1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156800912803987896</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1191-1232
Issue
9
Volume
12
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dietary Phytochemicals In The Chemoprevention And Treatment Of Hepatocellular Carcinoma: In Vivo Evidence, Molecular Targets, And Clinical Relevance
Publisher
An entity responsible for making the resource available
Current Cancer Drug Targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
acid phenethyl ester; altered hepatic foci; black tea; carcinoma; Chemoprevention; dietary; diethylnitrosamine-induced hepatocarcinogenesis; hepatocarcinogenesis; hepatocellular; implanted; liver cancer; liver preneoplastic foci; model; multiorgan carcinogenesis model; nitrosodiethylamine-induced; nude-mice; Oncology; phenobarbital-induced hepatocarcinogenesis; phytochemicals; polyphenols; resistant hepatocyte; treatment
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Waghray A; Kruse J A; Novotny N A; Darvesh A S
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most common and lethal cancers, is a growing menace in modern society. Until recently, the majority of detected cases of liver cancer have been found in the developing nations of Asia and Africa; however, its occurrence has significantly increased in the United States. HCC occurs due to several etiologies, such as alcoholism, dietary carcinogens, iron overload, viral hepatitis, as well as several hepatic chronic diseases. In view of the limited treatment options, such as surgery and transplantation, a critical need exists to examine alternative approaches. The use of phytochemicals obtained from dietary sources provides a novel and fascinating preventive and therapeutic approach against HCC. Dietary phytochemicals possess potent antioxidant and anti-inflammatory properties which are extremely critical to combat the significant oxidative stress and inflammation implicated in liver cancer. An impressive number of phytochemicals have shown considerable promise as candidates for the prevention and treatment of HCC. In this article, we systematically review the in vivo pre-clinical evidence documenting the chemopreventive and therapeutic potential of several important dietary phytochemicals in HCC. This review critically examines the molecular mechanisms of the pharmacological effects of the aforementioned animal studies. Clinical and epidemiological studies are also highlighted in this review. Emerging issues such as bioavailability, dose optimization, targeted drug delivery, role of botanical extracts and synergy are also discussed. Finally, current challenges, limitations, future directions, innovative concepts and novel hypotheses for the use of dietary phytochemicals in the chemoprevention and amelioration of human HCC are presented.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">10.2174/156800912803987896</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acid phenethyl ester
altered hepatic foci
Bishayee A
black tea
Carcinoma
Chemoprevention
Current cancer drug targets
Darvesh A S
Department of Pharmaceutical Sciences
Dietary
diethylnitrosamine-induced hepatocarcinogenesis
Hepatocarcinogenesis
Hepatocellular
Implanted
Journal Article or Conference Abstract Publication
Kruse J A
Liver cancer
liver preneoplastic foci
model
multiorgan carcinogenesis model
NEOMED College of Pharmacy
nitrosodiethylamine-induced
Novotny N A
nude-mice
oncology
phenobarbital-induced hepatocarcinogenesis
phytochemicals
Polyphenols
resistant hepatocyte
Thoppil R J
Treatment
Waghray A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156800912803987896</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1191-1232
Issue
9
Volume
12
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dietary Phytochemicals In The Chemoprevention And Treatment Of Hepatocellular Carcinoma: In Vivo Evidence, Molecular Targets, And Clinical Relevance
Publisher
An entity responsible for making the resource available
Current Cancer Drug Targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
acid phenethyl ester; altered hepatic foci; black tea; carcinoma; chemoprevention; dietary; diethylnitrosamine-induced hepatocarcinogenesis; hepatocarcinogenesis; hepatocellular; implanted; liver cancer; liver preneoplastic foci; model; multiorgan carcinogenesis model; nitrosodiethylamine-induced; nude-mice; Oncology; phenobarbital-induced hepatocarcinogenesis; phytochemicals; polyphenols; resistant hepatocyte; treatment
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Waghray A; Kruse J A; Novotny N A; Darvesh A S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/156800912803987896" target="_blank" rel="noreferrer noopener">10.2174/156800912803987896</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acid phenethyl ester
altered hepatic foci
Bishayee A
black tea
Carcinoma
Chemoprevention
Current cancer drug targets
Darvesh A S
Department of Pharmaceutical Sciences
Dietary
diethylnitrosamine-induced hepatocarcinogenesis
Hepatocarcinogenesis
Hepatocellular
Implanted
Kruse J A
Liver cancer
liver preneoplastic foci
model
multiorgan carcinogenesis model
NEOMED College of Pharmacy
nitrosodiethylamine-induced
Novotny N A
nude-mice
oncology
phenobarbital-induced hepatocarcinogenesis
phytochemicals
Polyphenols
resistant hepatocyte
Thoppil R J
Treatment
Waghray A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00230973" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00230973</a>
Pages
607–619
Issue
3
Volume
84
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The neural basis of the behaviorally relevant N1 component of the somatosensory-evoked potential in SI cortex of awake monkeys: evidence that backward cortical projections signal conscious touch sensation.
Publisher
An entity responsible for making the resource available
Experimental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1905-06
Subject
The topic of the resource
Male; Animals; Electric Stimulation; Behavior; Synapses/physiology; Neural Pathways/physiology; Cerebral Cortex/*physiology; Macaca mulatta; Peripheral Nerves/physiology; Skin Physiological Phenomena; Touch/*physiology; Evoked Potentials; Electrodes; Animal/*physiology; Implanted; Somatosensory/*physiology
Creator
An entity primarily responsible for making the resource
Cauller L J; Kulics A T
Description
An account of the resource
Studies of touch intensity discrimination in monkeys have identified a component of the somatosensory-evoked cortical potential, N1, generated within 50 ms of the stimulus, that predicts their behavioral performance. This study employed multiple-electrode arrays with relatively high spatial resolution (0.1 or 0.2 mm spacing) to record laminar profiles of somatosensory-evoked potentials (SEPs), multiple unit activity (MUA) and current source-densities (CSDs) at several sites across the postcentral gyri of two awake monkeys. This high resolution laminar analysis strongly supports our earlier hypothesis based upon low resolution data that N1 is generated by synaptic excitation targeted specifically at the most superficial cortical layers I/II: (1) The excitatory nature of N1 was indicated by elevated MUA which was maximal in layer III and extended down to subcortical white matter where fiber activity exceeded prestimulus levels; (2) In addition to CSD analysis, the observation that N1 was maximally negative within 0.10 mm of the border between layers I and II verified the superficial site of N1 synaptic excitation regardless of conductivity boundaries near the pial surface. A review of the anatomical literature finds that the most likely inputs responsible for N1 activation are the "backward" cortico-cortical projections from secondary somatosensory areas to SI which in area 1 are the major source of sensory-related input that specifically terminates in layers I/II. We suggest, therefore, that backward projections are involved in the conscious process of touch sensation as it is signaled by N1.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00230973" target="_blank" rel="noreferrer noopener">10.1007/bf00230973</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animal/*physiology
Animals
Behavior
Cauller L J
Cerebral Cortex/*physiology
Electric Stimulation
Electrodes
Evoked Potentials
Experimental brain research
Implanted
Kulics A T
Macaca mulatta
Male
Neural Pathways/physiology
Peripheral Nerves/physiology
Skin Physiological Phenomena
Somatosensory/*physiology
Synapses/physiology
Touch/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.22-23-10449.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.22-23-10449.2002</a>
Pages
10449–10460
Issue
23
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Projection to the inferior colliculus from the basal nucleus of the amygdala.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Species Specificity; Action Potentials/physiology; Amygdala/*cytology/physiology; Dextrans; Rhodamines; Fluorescent Dyes; *Stilbamidines; Auditory Cortex/cytology; Auditory Pathways/*cytology/physiology; Axonal Transport/physiology; Brain Stem/cytology; Chiroptera/*anatomy & histology/physiology; Cholera Toxin/pharmacokinetics; Inferior Colliculi/*cytology/physiology; Neurons/cytology/physiology; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Electrodes; Implanted
Creator
An entity primarily responsible for making the resource
Marsh Robert A; Fuzessery Zoltan M; Grose Carol D; Wenstrup Jeffrey J
Description
An account of the resource
This report describes a projection from the amygdala, a forebrain center mediating emotional expression, to the inferior colliculus (IC), the midbrain integration center of the ascending auditory system. In the IC of mustached bats (Pteronotus parnellii) and pallid bats (Antrozous pallidus), we placed deposits of retrograde tracers at physiologically defined sites and then searched for retrogradely labeled somata in the forebrain. Labeling was most sensitive in experiments using cholera toxin B-subunit as tracer. We consistently observed retrograde labeling in a single amygdalar subdivision, the magnocellular subdivision of the basal nucleus (Bmg). The Bmg is distinctive across mammals, containing the largest cells in the amygdala and the most intense acetylcholinesterase staining. Labeled amygdalar cells occurred ipsilateral and contralateral to IC deposits, but ipsilateral labeling was greater, averaging 72%. Amygdalar labeling was observed after tracer deposits throughout the IC, including its central nucleus (ICC). In comparison, labeling in the auditory cortex (layer V) was heavily ipsilateral (averaging 92%). Cortical labeling depended on the location of IC deposits: dorsomedial deposits resulted in the most labeled cells, whereas ventrolateral deposits labeled few or no cortical cells. Cortical labeling occurred after several deposits in the ICC. Across experiments, the average number of labeled cells in the amygdala was similar to that in the auditory cortex, indicating that the amygdalocollicular projection is significant. The results demonstrate a direct, widespread projection from the basal amygdala to the IC. They also suggest the presence of a rapid thalamoamygdalocollicular feedback circuit that may impose emotional content onto processing of sensory stimuli at a relatively low level of an ascending sensory pathway.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/jneurosci.22-23-10449.2002" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.22-23-10449.2002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Stilbamidines
2002
Acoustic Stimulation/methods
Action Potentials/physiology
Amygdala/*cytology/physiology
Animals
Auditory Cortex/cytology
Auditory Pathways/*cytology/physiology
Axonal Transport/physiology
Brain Stem/cytology
Chiroptera/*anatomy & histology/physiology
Cholera Toxin/pharmacokinetics
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans
Electrodes
Fluorescent Dyes
Fuzessery Zoltan M
Grose Carol D
Implanted
Inferior Colliculi/*cytology/physiology
Marsh Robert A
NEOMED College of Medicine
Neurons/cytology/physiology
Rhodamines
Species Specificity
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.21-03-j0002.2001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.21-03-j0002.2001</a>
Pages
RC124–RC124
Issue
3
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spectral integration in the inferior colliculus: role of glycinergic inhibition in response facilitation.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-02
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Neural Inhibition/drug effects/*physiology; Chiroptera; Inferior Colliculi/drug effects/*physiology; Wakefulness/physiology; Auditory Pathways/drug effects/physiology; Echolocation/*physiology; Glycine Agents/administration & dosage; Glycine/*metabolism; Iontophoresis; Pitch Perception/drug effects/*physiology; Strychnine/administration & dosage; Electrodes; Animal/physiology; Vocalization; Implanted
Creator
An entity primarily responsible for making the resource
Wenstrup J J; Leroy S A
Description
An account of the resource
This study examined the contribution of glycinergic inhibition to the time-sensitive spectral integration performed by neurons in the inferior colliculus of the mustached bat (Pteronotus parnellii). These neurons are sometimes called combination-sensitive because they display facilitatory (or inhibitory) responses to the combination of distinct spectral elements in sonar or social vocalizations. Present in a wide range of vertebrates, their temporally and spectrally selective integration is thought to endow them with the ability to discriminate among social vocalizations or to analyze particular cues concerning sonar targets. The mechanisms that underlie these responses or the sites in the auditory system where they are created are not known. We examined combination-sensitive neurons that are facilitated by the presentation of two different harmonic elements of the bat's sonar call and echo. Responses of 24 single units were recorded before and during local application of strychnine, an antagonist of glycinergic inhibition. For each of the 24 units, strychnine application eliminated or greatly reduced temporally sensitive facilitation. There was no difference in this effect for neurons tuned to frequencies associated with the frequency-modulated or the constant-frequency sonar components. These results are unusual because glycine is considered to be an inhibitory neurotransmitter, but here it appears to be essential for the expression of combination-sensitive facilitation. The findings provide strong evidence that facilitatory combination-sensitive response properties present throughout the mustached bat's auditory midbrain, thalamus, and cortex originate through neural interactions in the inferior colliculus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/jneurosci.21-03-j0002.2001" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.21-03-j0002.2001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Acoustic Stimulation/methods
Animal/physiology
Animals
Auditory Pathways/drug effects/physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/*physiology
Electrodes
Glycine Agents/administration & dosage
Glycine/*metabolism
Implanted
Inferior Colliculi/drug effects/*physiology
Iontophoresis
Leroy S A
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Pitch Perception/drug effects/*physiology
Strychnine/administration & dosage
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vocalization
Wakefulness/physiology
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.20-22-08533.2000" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.20-22-08533.2000</a>
Pages
8533–8541
Issue
22
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spectral integration in the inferior colliculus of the mustached bat.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-11
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Neurons/physiology; Acoustic Stimulation; Inferior Colliculi/*physiology; Action Potentials/physiology; Auditory Threshold/physiology; Brain Mapping; Reaction Time/physiology; Pitch Perception/*physiology; Auditory Pathways/physiology; Animal Communication; Sound Spectrography; Stereotaxic Techniques; Electrodes; Animal/physiology; Vocalization; Implanted
Creator
An entity primarily responsible for making the resource
Leroy S A; Wenstrup J J
Description
An account of the resource
Acoustic behaviors including orientation and social communication depend on neural integration of information across the sound spectrum. In many species, spectral integration is performed by combination-sensitive neurons, responding best when distinct spectral elements in sounds are combined. These are generally considered a feature of information processing in the auditory forebrain. In the mustached bat's inferior colliculus (IC), they are common in frequency representations associated with sonar signals but have not been reported elsewhere in this bat's IC or the IC of other species. We examined the presence of combination-sensitive neurons in frequency representations of the mustached bat's IC not associated with biosonar. Seventy-five single-unit responses were recorded with the best frequencies in 10-23 or 32-47 kHz bands. Twenty-six displayed single excitatory tuning curves in one band with no additional responsiveness to a second signal in another band. The remaining 49 responded to sounds in both 10-23 and 32-47 kHz bands, but response types varied. Sounds in the higher band were usually excitatory, whereas sounds in the lower band either facilitated or inhibited responses to the higher frequency signal. Interactions were usually strongest when the higher and lower frequency stimuli were presented simultaneously, but the strength of interactions varied. Over one-third of the neurons formed a distinct subset; they responded most sensitively to bandpass noise, and all were combination sensitive. We suggest that these combination-sensitive interactions are activated by elements of mustached bat social vocalizations. If so, neuronal integration characterizing analysis of social vocalizations in many species occurs in the IC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/jneurosci.20-22-08533.2000" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.20-22-08533.2000</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Acoustic Stimulation
Action Potentials/physiology
Animal Communication
Animal/physiology
Animals
Auditory Pathways/physiology
Auditory Threshold/physiology
Brain Mapping
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrodes
Implanted
Inferior Colliculi/*physiology
Leroy S A
NEOMED College of Medicine
Neurons/physiology
Pitch Perception/*physiology
Reaction Time/physiology
Sound Spectrography
Stereotaxic Techniques
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vocalization
Wenstrup J J