1
40
6
-
Text
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URL Address
<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-020-00829-x</a>
ISSN
2190-3948 2190-393X
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s13346-020-00829-x</a>
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Overcoming barriers confronting application of protein therapeutics in bone fracture healing.
Publisher
An entity responsible for making the resource available
Drug delivery and Translational Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-11
Subject
The topic of the resource
Osteoporosis; Drug delivery; Implants; Bone regeneration; Osteoinductive proteins; Osteopenia
Creator
An entity primarily responsible for making the resource
Czech T; Oyewumi MO
Description
An account of the resource
Bone fracture is a major contributor to debilitation and death among patients with bone diseases. Thus, osteogenic protein therapeutics and their delivery to bone have been extensively researched as strategies to accelerate fracture healing. To prevent morbidity and mortality of fractures, which occur frequently in the aging population, there is a critical need for development of first-line therapeutics. Bone morphogenic protein-2 (BMP-2) has been at the forefront of bone regeneration research for its potent osteoinduction, despite safety concerns and biophysiological obstacles of delivery to bone. However, continued pursuit of osteoinductive proteins as a therapeutic option is largely aided by drug delivery systems, playing an imperative role in enhancing safety and efficacy. In this work, we highlighted several types of drug delivery platforms and their biomaterials, to evaluate the suitability in overcoming challenges of therapeutic protein delivery for bone regeneration. To showcase the clinical considerations for each type of platform, we have assessed the most common route of administration strategies for bone regeneration, classifying the platforms as implantable or injectable. Additionally, we have analyzed the commonly utilized models and methodology for safety and efficacy evaluation of these osteogenic protein-loaded systems, to present clinical opinions for future directions of research in this field. It is hoped that this review will promote research and development of clinically translatable osteogenic protein therapeutics, while targeting first-line treatment status for achieving desired outcomes of fracture healing. Graphical abstract.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">10.1007/s13346-020-00829-x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
August 2020 List
Bone regeneration
Czech T
Department of Pharmaceutical Sciences
Drug delivery
Drug delivery and translational research
Implants
journalArticle
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Osteoinductive proteins
osteopenia
Osteoporosis
Oyewumi MO
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
79-89
Issue
1
Volume
4
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
RHEUMATOLOGIC PRESENTATION AND WORK-UP OF SILICONE-EXPOSED PATIENTS
Publisher
An entity responsible for making the resource available
International Journal of Occupational Medicine and Toxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
augmentation; Biochemistry & Molecular Biology; disease; Environmental & Occupational Health; Environmental Sciences & Ecology; fibromyalgia; implants; polymyositis; Public; scleroderma; silicone; sjogrens syndrome; systemic lupus erythematosus; systemic-sclerosis; Toxicology
Creator
An entity primarily responsible for making the resource
Rothschild B M
Description
An account of the resource
Determination of the relationship between silicone breast implants and rheumatologic disease requires comprehensive analysis of large numbers of individuals, both with implants and without. Techniques of history taking and physical examination, predicated upon a working knowledge of rheumatologic disease, form the basis for identification of potentially associated rheumatologic conditions. Symptoms are reported 6 to 7 years after prosthesis placement, with a range of 2 months to 25 years. The number of individuals with breast implants who have developed scleroderma and other rheumatologic disorders does not appear to be greater than that expected on the basis of chance alone. However, much larger populations must be studied to determine ifa small risk does exist. While fibromyalgia may be an exception to that perspective, it too requires additional study.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
augmentation
Biochemistry & Molecular Biology
Disease
Environmental & Occupational Health
Environmental Sciences & Ecology
fibromyalgia
Implants
International Journal of Occupational Medicine and Toxicology
Journal Article
polymyositis
Public
Rothschild B M
Scleroderma
silicone
sjogrens syndrome
systemic lupus erythematosus
systemic-sclerosis
Toxicology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/adem.201500282" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/adem.201500282</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
518-531
Issue
4
Volume
18
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation
Publisher
An entity responsible for making the resource available
Advanced Engineering Materials
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-04
Subject
The topic of the resource
differentiation; energy; hydrophilicity; implants; in-vitro; Materials Science; nanotopography; osseointegration; osteoactivin; osteoblast lineage cells; responses
Creator
An entity primarily responsible for making the resource
Park B W; Krieger J; Sondag G R; Moussa F M; Rankenberg J; Safadi F F; Gatsonis N A; McGimpsey W G; Lambert C R; Malcuit C
Description
An account of the resource
We provide a comparative analysis of protein adsorption, primary human cell behavior, and biofilm formation on modified titanium substrates of either micro-, nano-, or hybrid micro/nano-scale feature sizes. While studies revealed that nano-scale structures initially decreased the attachment and spreading of both human fibroblasts (hDFs) and mesenchymal stem cells (hMSCs), hMSC differentiation studies revealed that hybrid structures promoted the highest levels of osteogenic gene expression and attenuated biofilm formation by Staphylococcus epidermidis. Taken together, this novel approach of generating a hybrid topographical feature results in a potential implant material capable of enhanced dermal cell adhesion and osteogenic differentiation while limiting biofilm accumulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/adem.201500282" target="_blank" rel="noreferrer noopener">10.1002/adem.201500282</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2016
Advanced Engineering Materials
differentiation
energy
Gatsonis N A
hydrophilicity
Implants
in-vitro
Journal Article
Krieger J
Lambert C R
Malcuit C
Materials Science
McGimpsey W G
Moussa F M
nanotopography
osseointegration
OSTEOACTIVIN
osteoblast lineage cells
Park B W
Rankenberg J
responses
Safadi F F
Sondag G R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000151432" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000151432</a>
Pages
241–244
Issue
1
Volume
189
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tissue engineering models of human digits: effect of periosteum on growth plate cartilage development.
Publisher
An entity responsible for making the resource available
Cells, tissues, organs
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009
Subject
The topic of the resource
*Models; *Tissue Engineering; Animals; Articular/*growth & development; Biological; Cartilage; Cattle; Experimental; Fingers/diagnostic imaging; Growth Plate/cytology/*growth & development; Humans; Implants; Male; Mice; Nude; Periosteum/*physiology; Radiography
Creator
An entity primarily responsible for making the resource
Landis William J; Jacquet Robin; Lowder Elizabeth; Enjo Mitsuhiro; Wada Yoshitaka; Isogai Noritaka
Description
An account of the resource
Tissue-engineered middle phalanx constructs of human digits were investigated to determine whether periosteum wrapped partly about model midshafts mediated cartilage growth plate formation. Models were fabricated by suturing ends of polymer midshafts in a human middle phalanx shape with polymer sheets seeded with heterogeneous chondrocyte populations from bovine articular cartilage. Half of each midshaft length was wrapped with bovine periosteum. Constructs were cultured, implanted in nude mice for up to 20 weeks, harvested and treated histologically to assess morphology and cartilage proteoglycans. After 20 weeks of implantation, chondrocyte-seeded sheets adjacent to periosteum-wrapped midshaft halves established cartilage growth plates resembling normal tissue in vivo. Sheets adjacent to midshafts without periosteum had disorganized cells and no plate formation. Proteoglycans were present at both midshaft ends. Periosteum appears to guide chondrocytes toward growth plate cartilage organization and tissue engineering provides means for carefully examining construct development of this tissue.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000151432" target="_blank" rel="noreferrer noopener">10.1159/000151432</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Models
*Tissue Engineering
2009
Animals
Articular/*growth & development
Biological
Cartilage
Cattle
Cells, tissues, organs
Enjo Mitsuhiro
Experimental
Fingers/diagnostic imaging
Growth Plate/cytology/*growth & development
Humans
Implants
Isogai Noritaka
Jacquet Robin
Landis William J
Lowder Elizabeth
Male
Mice
Nude
Periosteum/*physiology
Radiography
Wada Yoshitaka
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00006534-200003000-00019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00006534-200003000-00019</a>
Pages
953–963
Issue
3
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.
Publisher
An entity responsible for making the resource available
Plastic and reconstructive surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-03
Subject
The topic of the resource
*Fibrin Tissue Adhesive; *Osteogenesis; Animals; Bone and Bones/chemistry/cytology/diagnostic imaging; Cattle; Cells; Cultured; Experimental; Implants; Injections; Mice; Non-programmatic; Nude; Osteopontin; Periosteum/*cytology; Radiography; Sialoglycoproteins/analysis
Creator
An entity primarily responsible for making the resource
Isogai N; Landis W J; Mori R; Gotoh Y; Gerstenfeld L C; Upton J; Vacanti J P
Description
An account of the resource
The purpose of this study was to determine whether a combination of fibrin glue and cultured periosteal cells will result in new bone formation at heterotopic sites in nude mice. Growing cells and developing matrices surrounding periosteal explants from the diaphyses of radii of newborn calves were minced and mixed with fibrin glue in a syringe. The cell/matrix-fibrin glue admixture was then injected into the subcutaneous space on the dorsum of athymic nude mice. After 12 weeks of implantation, gross morphology and histologic investigations showed newly formed bone structures in all cell/matrix-fibrin glue admixtures, but none in fibrin glue injected alone and used as control samples. Osteopontin, a protein important in bone development, was identified by a Western blot assay of the cell/matrix-fibrin glue composite. This study supports the feasibility of initiating site-directed formation of bone structures at heterotopic tissue sites by means of injection of cultured periosteal cells and matrix in a fibrin glue carrier.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00006534-200003000-00019" target="_blank" rel="noreferrer noopener">10.1097/00006534-200003000-00019</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fibrin Tissue Adhesive
*Osteogenesis
2000
Animals
Bone and Bones/chemistry/cytology/diagnostic imaging
Cattle
Cells
Cultured
Experimental
Gerstenfeld L C
Gotoh Y
Implants
Injections
Isogai N
Landis W J
Mice
Mori R
Non-programmatic
Nude
Osteopontin
Periosteum/*cytology
Plastic and reconstructive surgery
Radiography
Sialoglycoproteins/analysis
Upton J
Vacanti J P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1089/ten.TEA.2009.0078" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/ten.TEA.2009.0078</a>
Pages
3765–3778
Issue
12
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Development of bone and cartilage in tissue-engineered human middle phalanx models.
Publisher
An entity responsible for making the resource available
Tissue engineering. Part A
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
*Models; Aggrecans/genetics/metabolism; Animals; Biological; Bone Development/drug effects/*physiology; Calcium Phosphates/pharmacology; Cartilage/cytology/drug effects/*growth & development; Cattle; Chondrocytes/cytology/drug effects/metabolism; Collagen Type II/genetics/metabolism; Durapatite/pharmacology; Electron; Experimental; Finger Phalanges/cytology/diagnostic imaging/drug effects/*physiology; Gene Expression Profiling; Gene Expression Regulation/drug effects; Humans; Implants; Integrin-Binding Sialoprotein; Mice; Microscopy; Paraffin Embedding; Periosteum/cytology/drug effects; Polyesters/pharmacology; Radiography; Scanning; Sialoglycoproteins/genetics/metabolism; Tissue Engineering/*methods; Tissue Scaffolds/chemistry
Creator
An entity primarily responsible for making the resource
Wada Yoshitaka; Enjo Mitsuhiro; Isogai Noritaka; Jacquet Robin; Lowder Elizabeth; Landis William J
Description
An account of the resource
Human middle phalanges were tissue-engineered with midshaft scaffolds of poly(L-lactide-epsilon-caprolactone) [P(LA-CL)], hydroxyapatite-P(LA-CL), or beta-tricalcium phosphate-P(LA-CL) and end plate scaffolds of bovine chondrocyte-seeded polyglycolic acid. Midshafts were either wrapped with bovine periosteum or left uncovered. Constructs implanted in nude mice for up to 20 weeks were examined for cartilage and bone development as well as gene expression and protein secretion, which are important in extracellular matrix (ECM) formation and mineralization. Harvested 10- and 20-week constructs without periosteum maintained end plate cartilage but no growth plate formation. They also consisted of chondrocytes secreting type II collagen and proteoglycan, and they were composed of midshaft regions devoid of bone. In all periosteum-wrapped constructs at like times, end plate scaffolds held chondrocytes elaborating type II collagen and proteoglycan and cartilage growth plates resembling normal tissue. Chondrocyte gene expression of type II collagen, aggrecan, and bone sialoprotein varied depending on midshaft composition, presence of periosteum, and length of implantation time. Periosteum produced additional cells, ECM, and mineral formation within the different midshaft scaffolds. Periosteum thus induces midshaft development and mediates chondrocyte gene expression and growth plate formation in cartilage regions of phalanges. This work is important for understanding developmental principles of tissue-engineered phalanges and by extension those of normal growth plate cartilage and bone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/ten.TEA.2009.0078" target="_blank" rel="noreferrer noopener">10.1089/ten.TEA.2009.0078</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Models
2009
Aggrecans/genetics/metabolism
Animals
Biological
Bone Development/drug effects/*physiology
Calcium Phosphates/pharmacology
Cartilage/cytology/drug effects/*growth & development
Cattle
Chondrocytes/cytology/drug effects/metabolism
Collagen Type II/genetics/metabolism
Durapatite/pharmacology
Electron
Enjo Mitsuhiro
Experimental
Finger Phalanges/cytology/diagnostic imaging/drug effects/*physiology
Gene Expression Profiling
Gene Expression Regulation/drug effects
Humans
Implants
Integrin-Binding Sialoprotein
Isogai Noritaka
Jacquet Robin
Landis William J
Lowder Elizabeth
Mice
Microscopy
Paraffin Embedding
Periosteum/cytology/drug effects
Polyesters/pharmacology
Radiography
Scanning
Sialoglycoproteins/genetics/metabolism
Tissue engineering. Part A
Tissue Engineering/*methods
Tissue Scaffolds/chemistry
Wada Yoshitaka