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Text
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URL Address
<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/08990220020021366</a>
Pages
66–75
Issue
1
Volume
18
Dublin Core
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Title
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Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.
Publisher
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Somatosensory & Motor Research
Date
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2001
2001
Subject
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*Peripheral Nerve Injuries; Aging/*physiology; Animals; Computer-Assisted; Hot Temperature; Image Processing; Immunohistochemistry; Inbred BN; Inbred F344; Neurokinin-1/*metabolism; Rats; Receptors; Spinal Cord/*metabolism; Thermosensing/physiology; Touch/physiology
Creator
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Cruce W L; Lovell J A; Crisp T; Stuesse S L
Description
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Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases in the spinal cord ipsilateral to the injury and the increases are correlated with the development of thermal hyperalgesia (Goff et al., 1998). Thus we postulated that aged rats might display an increased sensitivity to thermal stimulation before peripheral nerve injury and that they might respond differently to injury than do younger rats. To test this hypothesis, we used the Bennett and Xie model (1988) of chronic constriction injury (CCI) to the sciatic nerve to induce a neuropathic pain condition. We investigated the effect of age on changes in NK-1 ir in superficial layers of the dorsal horn and on numbers of NK ir cells in deeper laminae at the L4-L5 levels of the spinal cord after CCI.
Identifier
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<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">10.1080/08990220020021366</a>
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*Peripheral Nerve Injuries
2001
Aging/*physiology
Animals
Computer-Assisted
Crisp T
Cruce W L
Hot Temperature
Image Processing
Immunohistochemistry
Inbred BN
Inbred F344
Lovell J A
Neurokinin-1/*metabolism
Rats
Receptors
Somatosensory & motor research
Spinal Cord/*metabolism
Stuesse S L
Thermosensing/physiology
Touch/physiology