Browse Items · NEOMED Bibliography Database

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…

Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.

These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu…

Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury.

Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases…

Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.

In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were…

Tags: 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Biogenic Monoamines/*metabolism, Dluzen D E, Dopamine/metabolism, Inbred F344, Male, Mechanisms of ageing and development, Olfactory Bulb/*metabolism, Rats, Serotonin/metabolism

Lack of an inhibitory effect of hyperprolactinemia on androgen-dependent marking.

An experiment was performed to determine if hyperprolactinemia (chronically elevated serum prolactin levels), which inhibits testosterone-activated male sexual activity, also affects other androgen-dependent behaviors. Thus defecation and urine…

Hyperprolactinemia preferentially inhibits erectile function in adrenalectomized male rats.

To determine if the inhibitory effects of hyperprolactinemia on sexual arousal and serum LH levels could be dissociated from those on erectile function, copulatory behavior was examined in pituitary-grafted, adrenalectomized male rats that had been…

Tags: *Penile Erection/drug effects, 1990, Adrenalectomy, Animals, Body Weight, Chronic Disease, Doherty P C, Hyperprolactinemia/*physiopathology, Inbred F344, Life sciences, Luteinizing Hormone/blood/*metabolism, Male, Matt K S, Pituitary Gland/transplantation, Prolactin/blood/metabolism, Rats, Testosterone/pharmacology, Wu D E

Alterations in neurotransmitter amino acid content in the aging rat striatum are subregion dependent.

The topographical distribution of putative neurotransmitter amino acids in both

Tags: 1990, Aging/*metabolism, Amino Acids/*analysis, Animals, Corpus Striatum/*analysis, Donzanti B A, Inbred F344, Male, Neurobiology of aging, Neurotransmitter Agents/*analysis, Rats, Ung A K

Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride.

Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system. Inhibition of uPA prevents the conversion of plasminogen to tumor cell surface bound plasmin which is required for…

The re-expression of two myosin heavy chains in regenerated rat muscle spindles.

The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for…

Tags: *Gene Expression Regulation, *Regeneration, 1989, Afferent/*physiology, Animals, Fei C, Female, Immunohistochemistry, Inbred F344, Muscle Denervation, Muscles/innervation/*metabolism, Myosins/*metabolism, Neurons, Neuroscience letters, Rats, Walro J M

Age related changes of social memory/recognition in male Fischer 344 rats.

Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus…

The effect of various insufflation gases on tumor implantation in an animal model.

OBJECTIVE: The expanded use of laparoscopy has led to reports of tumor dissemination and spread to laparoscopic port sites. We previously showed that carbon dioxide insufflation produced tumor dissemination compared with laparotomy. It is unknown…

The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.

Previous research has demonstrated that the antinociceptive efficacy of opioids decreases with advancing age. This study utilized radioligand binding techniques to determine if this decline is due to a change in the receptor density (Bmax) and/or…

The effects of aging on spinal neurochemistry in the rat.

The purpose of this study was to investigate how the aging process alters the basal levels of serotonin, norepinephrine, dopamine, and their respective metabolites in the spinal cord using high-performance liquid chromatography and electrochemical…

Tags: 1997, Aging/*metabolism, Animals, Brain research bulletin, Chromatography, Crisp T, Dopamine/metabolism, Electrochemistry/methods, Gordon T L, High Pressure Liquid, Inbred F344, King M A, Ko M L, Male, Norepinephrine/metabolism, Rats, Serotonin/metabolism, Spinal Cord/*metabolism

Strain differences in neuropathic hyperalgesia.

The purpose of this study was to investigate strain-related differences in the onset and maintenance of thermal hyperalgesia following the induction of peripheral nerve injury in two inbred strains of rats (Fischer 344 and Lewis) and two outbred…

Tags: 2000, Animals, Chronic Disease, Crisp T, Cruce W L, Cytokines/physiology, Hyperalgesia/*etiology, Inbred F344, Inbred Lew, Ligation, Lovell J A, Male, Pharmacology, biochemistry, and behavior, Rats, Sciatic Nerve/physiology, Species Specificity, Sprague-Dawley, Stuesse S L, Wistar

Neuropathic pain in aged rats: behavioral responses and astrocytic activation.

We used the Bennett and Xie (1988) model of chronic neuropathic pain to study the effect of age on thermal and tactile sensitivity and on astrocytic activation in the dorsal horn of the spinal cord after nerve injury. Fischer 344 FBNF1 hybrid rats in…

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