Browse Items · NEOMED Bibliography Database

Further evidence for the mechanisms that may mediate nicotine discrimination.

Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50…

Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron

Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.

In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury…

Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control…

Tags: *Conditioning, 1995, Analysis of Variance, Animals, European journal of pharmacology, Female, Inbred Strains, Male, Meehan S M, Mice, Movement/*drug effects, Nicotine/*pharmacology, Operant, Schechter J B, Schechter M D

In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.

The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a…

Tags: 1989, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Brain research, Caudate Nucleus/drug effects/*metabolism, Dopamine/*metabolism, Electrochemistry, Glynn G E, Homovanillic Acid/metabolism, Inbred Strains, Indoles/*pharmacology, Male, Mazindol/*pharmacology, Neurotransmitter Uptake Inhibitors/*pharmacology, Nomifensine/*pharmacology, Putamen/drug effects/*metabolism, Rats, Yamamoto B K

Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.

Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and…

Tags: 1990, Amphetamine/pharmacology, Animals, Boja J W, Discrimination (Psychology)/*drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Inbred Strains, Male, Norfenfluramine/pharmacology, Pentobarbital/pharmacology, Psychopharmacology, Rats, Reinforcement Schedule, Schechter M D

Inhibition of rat brain pyruvate dehydrogenase by thiamine analogs.

The effects of thiamine thiazolone (TT) and thiamine thiazolone pyrophosphate (TTPP) on the in vitro and in vivo inhibition of pyruvate dehydrogenase complex (PDHC) from rat cortex and hippocampus were characterized. TTPP decreased PDHC activity in…

Tags: 1988, Animals, Biochemical pharmacology, Brain/*enzymology, Cerebral Cortex/drug effects/enzymology, Hippocampus/drug effects/enzymology, Inbred Strains, Kandiko C T, Kinetics, Male, Pyruvate Dehydrogenase Complex/*antagonists & inhibitors, Rats, Smith D, Thiamine Pyrophosphate/analogs & derivatives/pharmacology, Thiamine/*analogs & derivatives/pharmacology, Yamamoto B K

Innervation of regenerated spindles in muscle grafts of the rat.

Features of the nerve supply and the encapsulated fibers of muscle spindles were assessed in grafted and normal extensor digitorum longus (EDL) muscles of rats by analysis of serial 10-microns frozen transverse sections stained for enzymes which…

Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.

Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each…

Tags: 1988, Alcohol (Fayetteville, N.Y.), Animal/drug effects, Animals, Behavior, Carbolines/*pharmacology, Conditioning (Psychology)/drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Signs S A

Inverse agonist properties of the FG 7142 discriminative stimulus.

A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained…

Tags: 1991, Animals, Appetite Depressants/*pharmacology, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, GABA-A/drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Reinforcement Schedule, Schechter M D, Stimulus/drug effects

Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.

Male rats were trained to discriminate the stimulus properties of the beta-carbolines 1,2,3,4-tetrahydro-beta-carboline (THBC) (15.0 mg/kg) or FG 7142 (5.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. Consistent with the…

Tags: 1991, Animals, Avoidance Learning/drug effects, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, GABA-A/*drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Stimulus/*drug effects

Lack of generalization of nisoxetine with amphetamine in the rat.

Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting…

Tags: *Discrimination (Psychology), 1988, Animals, Boja J W, Conditioning, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Fluoxetine/*analogs & derivatives/pharmacology, Inbred Strains, Male, Norepinephrine/antagonists & inhibitors, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Schechter M D

Lack of neuroleptic-like activity of l-fenfluramine.

Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were…

Tags: 1991, Animals, Antipsychotic Agents/*pharmacology, Cues, Discrimination (Psychology)/drug effects, Dopamine Agents/pharmacology, Dopamine Antagonists, Fenfluramine/*pharmacology, Inbred Strains, Male, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/pharmacology, Rats, Schechter M D

LSD produces conditioned place preference in male but not female fawn hooded rats.

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in…

Tags: *Cues, *Sex Characteristics, 1998, Analysis of Variance, Animals, Choice Behavior/*drug effects, Conditioning, Female, Humans, Inbred Strains, Lysergic Acid Diethylamide/*pharmacology, Male, Meehan S M, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.

Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40…

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion…

Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.

Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the…

Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.

Since estrogen exerts wide ranging effects within the central nervous system, it is important to investigate the sites and actions of this gonadal steroid hormone at extra-hypothalamic locations. In the present report, the effects of estrogen upon…

Modulatory effects of testosterone on

In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either…

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.

Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c.…

NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.

The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in…

Nomifensine alters sex differences in striatal dopaminergic function.

A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg…

Non-neural and neural expression of myosin heavy chains by regenerated intrafusal fibers of rats.

Expression of myosin heavy chain (MHC) isoforms was studied in rat soleus (SOL) and extensor digitorum longus (EDL) muscles which regenerated in the presence or absence of innervation. Frozen sections of two 5 day denervated SOL and EDL grafts, two…

Tags: *Muscle Denervation, *Nerve Regeneration, 1991, Afferent/*metabolism, Animals, Female, Inbred Strains, Kucera J, Motor Endplate/metabolism, Muscles/*metabolism/transplantation, Myosins/analysis/*biosynthesis, Narvy R, Neurons, Neuroscience letters, Organ Specificity, Rats, Walro J M

Norepinephrine is lateralized within the olfactory bulbs of male mice.

Concentrations and in vitro release of norepinephrine were determined from left and right olfactory bulbs of adult male CD-1 mice. Norepinephrine concentrations from the left olfactory bulbs were significantly greater than those of the right (p…

Tags: *Functional Laterality, *Sex Characteristics, 1996, Animals, Dluzen D E, Dopamine/metabolism, Inbred Strains, Journal of neurochemistry, Kreutzberg J D, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration, Potassium/pharmacology, Tissue Distribution

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Place conditioning reveals the rewarding aspect of social interaction in juvenile rats.

Rewards, as diverse as food, sweetened solutions, copulation, electrical brain stimulation, and drugs abused by humans, have been shown to condition place preferences in rats. Juvenile rats will readily learn to traverse a T-maze for the opportunity…

Tags: *Conditioning, *Motivation, *Social Behavior, *Social Environment, *Social Isolation, 1992, Animals, Calcagnetti D J, Classical/drug effects, Female, Inbred Strains, Male, Motor Activity/drug effects, Physiology & behavior, Play and Playthings, Rats, Schechter M D, Scopolamine/pharmacology, Social Dominance

Possible serotonergic and dopaminergic mediation of the

Eight male rats previously trained to discriminate 2.0 mg/kg

Potentiation of cathinone by caffeine and nikethamide.

The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0.8 mg/kg l-cathinone and its…

Tags: 1989, Alkaloids/*pharmacology, Animals, Caffeine/*pharmacology, Discrimination (Psychology)/*drug effects, Drug Combinations/pharmacology, Drug Synergism, Inbred Strains, Male, Nikethamide/*pharmacology, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/pharmacology, Psychotropic Drugs/*pharmacology, Rats, Salicylates/pharmacology, Schechter M D

Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.

Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to…

Projections from the medial agranular cortex to brain stem visuomotor centers in rats.

Projections from medial agranular cortex to brain stem in rat were determined by use of the anterograde tracers Phaseolus vulgaris leucoagglutinin, or wheat germ agglutinin conjugated horseradish peroxidase. Axonal trajectories were also followed by…

Tags: 1990, Animals, Brain Stem/*cytology, Cerebral Cortex/*cytology, Experimental brain research, Female, Horseradish Peroxidase, Immunohistochemistry, Inbred Strains, Male, Newman D B, Phytohemagglutinins, Rats, Stuesse S L, Visual Pathways/*anatomy & histology, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, Wheat Germ Agglutinins

Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus.

In the present experiment peri-pubertal female mice were treated with a partially purified puberty accelerating urine extract (PAUE). Mice treated with the PAUE showed an advance in the onset of puberty as indicated by significantly increased uterine…

Tags: *Sex Characteristics, 1992, Animals, Brain research, Catecholamines/*metabolism, Dluzen D, Female, Guan X, Hypothalamus, Inbred Strains, Male, Mice, Middle/*metabolism, Olfactory Bulb/*metabolism, Sexual Maturation/*physiology, Urine/*physiology, Vandenbergh J G

Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary glands of intact male and female, ovariectomized, and estradiol benzoate-treated rats.

There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies…

Tags: *Ovariectomy, 1992, Animals, Anterior/*chemistry/drug effects/metabolism, Carrillo A J, Diestrus, Endocrinology, Estradiol/*pharmacology, Female, Immunohistochemistry, Inbred Strains, Male, Phelps C J, Pituitary Gland, Prolactin/blood/metabolism, Rats, Vasoactive Intestinal Peptide/*analysis/metabolism

Rats become acutely tolerant to cathine after amphetamine or cathinone administration.

The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine,…

Tags: 1990, Alkaloids/*pharmacology, Amphetamine/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Discrimination (Psychology)/drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Inbred Strains, Male, Phenylpropanolamine/*pharmacology, Psychopharmacology, Psychotropic Drugs/*pharmacology, Rats, Schechter M D, Thiazepines/pharmacology

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.

Monospecific antibody against purified rat liver cholesterol 7 alpha-hydroxylase cytochrome P-450 was used to screen a lambda gt11 cDNA library constructed from immuno-enriched polysomal RNA of cholestyramine-treated female rat liver. Two types of…

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.

Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography. These two cytochrome P-450 isozymes were similar in electrophoretic…

Role of dopamine D1 receptors in cocaine lethality.

One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment…

Tags: 1995, Animals, Benzazepines/pharmacology, Cocaine/*toxicity, Dopamine Agonists/pharmacology, Dopamine D1/agonists/antagonists & inhibitors/*drug effects, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Phenanthridines/pharmacology, Receptors, Schechter M D, Sex Characteristics

Serotonergic mediation of cocaine seizures in mice.

We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was…

Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

A series of three experiments were conducted to investigate the possible serotonergic and dopaminergic mediation of the discriminative stimulus properties of the "designer" drug MDMA. In Experiment 1, rats trained to discriminate 1.5 mg/kg (+/-)-MDMA…

Serotonin contributes to the spinal antinociceptive effects of morphine.

This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats…

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