1
40
97
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2016.04.008</a>
Pages
40–47
Volume
55
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
*QTL; *Recombinant inbred mice; *Sex Characteristics; *Sex differences; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/pharmacology; Animal; Animals; Corpus Striatum/drug effects/*metabolism; Disease Models; Dopamine/metabolism; Female; Gene Expression Regulation/drug effects/*genetics; Glial Fibrillary Acidic Protein/*metabolism; Homovanillic Acid/metabolism; Inbred Strains; Male; Mice; MPTP Poisoning/chemically induced/*pathology; Serotonin/metabolism; Species Specificity; Tyrosine 3-Monooxygenase/metabolism
Creator
An entity primarily responsible for making the resource
Alam Gelareh; Miller Diane B; O'Callaghan James P; Lu Lu; Williams Robert W; Jones Byron C
Description
An account of the resource
Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c. injection of 12.5mg/kg MPTP or saline. Forty-eight hours later the striatum was dissected for neurochemical analysis. Striatal dopamine (DA) and its metabolites, DOPAC and HVA, striatal serotonin (5-HT) and its metabolite, 5-HIAA, were analyzed using HPLC. Tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP), an astrocytic protein that increases during the astroglial response to neural injury, were measured using ELISA. There were wide genetic variations in the DA, DOPAC, HVA, TH and GFAP responses to MPTP. We also performed principal component analysis (PCA) on the difference values, saline minus MPTP, for DA, DOPAC, HVA and TH and mapped the dominant principal component to a suggestive QTL on chromosome 1 at the same location that we observed previously for males. Moreover, there were significant correlations between the sexes for the effect of MPTP on DA, HVA, and TH. Our findings suggest that the systems genetic approach as utilized here can help researchers understand the role of sex in individual differences. The same approach can pave the way to understand and pinpoint the genetic bases for individual differences in pathology attributable to toxicants. Such systems genetics approach has broad implications for elucidating gene-environment contributions to neurodegenerative diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2016.04.008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*QTL
*Recombinant inbred mice
*Sex Characteristics
*Sex differences
1-Methyl-4-phenyl-1
2
2016
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/pharmacology
Alam Gelareh
Animal
Animals
Corpus Striatum/drug effects/*metabolism
Department of Family & Community Medicine
Disease Models
Dopamine/metabolism
Female
Gene Expression Regulation/drug effects/*genetics
Glial Fibrillary Acidic Protein/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Jones Byron C
Lu Lu
Male
Mice
Miller Diane B
MPTP Poisoning/chemically induced/*pathology
NEOMED College of Medicine
Neurotoxicology
O'Callaghan James P
Serotonin/metabolism
Species Specificity
Tyrosine 3-Monooxygenase/metabolism
Williams Robert W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-0270(90)90021-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-0270(90)90021-7</a>
Pages
171–178
Issue
2
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A slice preparation preserving the callosal projection to contralateral visual cortex.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Female; Male; Animals; Rats; *Synaptic Transmission; In Vitro Techniques; Electrophysiology; Corpus Callosum/*physiology; Neurology/instrumentation; Visual Cortex/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Berry R L; Nowicky A; Teyler T J
Description
An account of the resource
Due to the curved path they follow, the visual callosal projections to areas OC1 and OC2 of the rat visual cortex have been inaccessible to studies using brain slices. In this paper we describe a new slice preparation in which a curved cutting blade was used to obtain slices in which callosal fibers projecting to OC1 or OC2 are preserved. Stimulation of the contralateral white matter resulted in EPSPs recorded in layer II/III and V cells of OC2 studied with intracellular recording. Current source density analysis of extracellular field potentials collected in OC1 and OC2 revealed laminar current sink patterns paralleling the laminar distribution of callosal terminations reported by Miller and Vogt (Dev. Brain Res., 14 (1984) 304-309). Exposure of slices to 2 mM kynurenic acid reversibly abolished current sinks in OC1 recorded in response to callosal stimulation indicating that glutamate receptors mediate the response of OC1 to callosal afferent activity. This new slicing technique can be readily adapted to study other systems in the nervous system in which neural processes follow curved trajectories.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-0270(90)90021-7" target="_blank" rel="noreferrer noopener">10.1016/0165-0270(90)90021-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Synaptic Transmission
1990
Animals
Berry R L
Corpus Callosum/*physiology
Electrophysiology
Female
In Vitro Techniques
Inbred Strains
Journal of neuroscience methods
Male
Neurology/instrumentation
Nowicky A
Rats
Teyler T J
Visual Cortex/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(87)90206-1</a>
Pages
153–156
Issue
2
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-10
Subject
The topic of the resource
Male; Time Factors; Animals; United States; Rats; Discrimination (Psychology); Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Legislation
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats were trained to discriminate 2.0 mg/kg
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(87)90206-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Boja J W
Discrimination (Psychology)
Dose-Response Relationship
Drug
Inbred Strains
Legislation
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Time Factors
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02245925</a>
Pages
221–226
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Amphetamine/pharmacology; Discrimination Learning/*drug effects; Discrimination (Psychology)/*drug effects; Norfenfluramine/pharmacology; Reinforcement Schedule; Pentobarbital/pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">10.1007/bf02245925</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Amphetamine/pharmacology
Animals
Boja J W
Discrimination (Psychology)/*drug effects
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Inbred Strains
Male
Norfenfluramine/pharmacology
Pentobarbital/pharmacology
Psychopharmacology
Rats
Reinforcement Schedule
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90350-4</a>
Pages
305–311
Issue
2
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-10
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Behavior; Serotonin/pharmacology; Discrimination (Psychology)/*drug effects; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Serotonin/physiology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Animal/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90350-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animal/*drug effects
Animals
Behavior
Boja J W
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Male
Norfenfluramine/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/pharmacology
Serotonin/physiology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
347–353
Issue
3
Volume
202
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Possible serotonergic and dopaminergic mediation of the
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Motor Activity/drug effects; Designer Drugs/pharmacology; Fenclonine/pharmacology; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology; Dopamine/*drug effects; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
Animals
Boja J W
Designer Drugs/pharmacology
Discrimination Learning/drug effects
Dopamine/*drug effects
European journal of pharmacology
Fenclonine/pharmacology
Inbred Strains
Male
Motor Activity/drug effects
N-Methyl-3
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*drug effects
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2012.03.003</a>
Pages
338–343
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Biomarkers/metabolism; Blotting; Body Temperature/drug effects; Body Weight/drug effects; Corpus Striatum/*drug effects/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine/*metabolism; Drug Synergism; HSP70 Heat-Shock Proteins/metabolism; Inbred Strains; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/*etiology/metabolism; Oxidative Stress/drug effects; Testosterone Propionate/*pharmacology; Vesicular Monoamine Transport Proteins/metabolism; Western
Creator
An entity primarily responsible for making the resource
Buletko A Blake; Dluzen Dean E; McDermott Janet L; Darvesh Altaf S; Geldenhuys Werner J
Description
An account of the resource
Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40 mg/kg) and rectal temperatures were measured. At 5 days post-MA, assays were performed to assess effects of these treatments. Maximal increases in body temperatures, that were significantly greater than oil-treated controls, were obtained in TP-treated mice. At 5 days post-MA, maximal weight reductions were obtained with TP-treated mice, while P-treated mice showed no significant decrease between the pre- versus post-MA determinations. Striatal dopamine concentrations showed maximal reductions and heat-shock protein-70 maximal increases in the TP group, with both differing significantly as compared with all other groups. Protein levels of dopamine transporters were significantly decreased in P-treated mice, while vesicular monoamine transporter-2 was significantly decreased in TP-treated mice. Taken together, these results suggest that testosterone exacerbates the deleterious effects of MA within male mice as indicated by a number of markers related to neurotoxicity. The changes in markers as associated with this enhanced neurotoxicity suggest that TP may increase thermal/energy responses and/or oxidative stress to produce this effect.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2012.03.003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Biomarkers/metabolism
Blotting
Body Temperature/drug effects
Body Weight/drug effects
Buletko A Blake
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
HSP70 Heat-Shock Proteins/metabolism
Inbred Strains
Male
McDermott Janet L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neurotoxicity Syndromes/*etiology/metabolism
Neurotoxicology and teratology
Oxidative Stress/drug effects
Testosterone Propionate/*pharmacology
Vesicular Monoamine Transport Proteins/metabolism
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0031-9384(92)90101-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0031-9384(92)90101-7</a>
Pages
667–672
Issue
4
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Place conditioning reveals the rewarding aspect of social interaction in juvenile rats.
Publisher
An entity responsible for making the resource available
Physiology & behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
*Conditioning; *Motivation; *Social Behavior; *Social Environment; *Social Isolation; Animals; Classical/drug effects; Female; Inbred Strains; Male; Motor Activity/drug effects; Play and Playthings; Rats; Scopolamine/pharmacology; Social Dominance
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
Rewards, as diverse as food, sweetened solutions, copulation, electrical brain stimulation, and drugs abused by humans, have been shown to condition place preferences in rats. Juvenile rats will readily learn to traverse a T-maze for the opportunity to interact with another similar-aged rat. This suggests that play behavior is rewarding. Experiment 1 examined whether play (as quantified by rough-and-tumble pinning) would act as a sufficient reward to condition a place preference (CPP). Experiment 2 examined whether pairings with a nonplaying partner would decrease the time spent in the preferred side and thus suggest a conditioned place aversion (CPA). In Experiment 1, dominant juvenile rats were given free access to a CPP apparatus and a side preference for one of the two physically distinct sides was determined. Dominant rats were then conditioned twice daily over four days in the CPP apparatus. They spent their first session confined in their preferred side with a scopolamine-treated partner (that rendered the partner unable to respond to play solicitations) and during the second session, dominant rats were confined to their less preferred side with a submissive play partner. The number of dorsal contacts, as well as frequency and duration of pinning, were recorded. Following conditioning, side preference was redetermined. A similar procedure was used in Experiment 2 except that the subjects underwent conditioning on their less-preferred side without a play partner. Results of Experiment 1 demonstrated that the dominant rats significantly increased (198.6%) the time spent on the originally less-preferred side after play conditioning.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0031-9384(92)90101-7" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(92)90101-7</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Conditioning
*Motivation
*Social Behavior
*Social Environment
*Social Isolation
1992
Animals
Calcagnetti D J
Classical/drug effects
Female
Inbred Strains
Male
Motor Activity/drug effects
Physiology & behavior
Play and Playthings
Rats
Schechter M D
Scopolamine/pharmacology
Social Dominance
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90548-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90548-g</a>
Pages
255–259
Issue
2
Volume
40
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
Animals; Antipsychotic Agents/administration & dosage/*pharmacology; Avoidance Learning/*drug effects; Dopamine/*metabolism; Inbred Strains; Injections; Intraventricular; Male; Motor Activity/*drug effects; Rats; Thiazepines/administration & dosage/*pharmacology
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine release is a necessary component for conditioned place preference (CPP), one reciprocal hypothesis may be that inhibition of dopamine release will result in conditioned place aversion (CPA). This hypothesis has been tested pharmacologically by employing CGS 10746B (CGS), a novel neuroleptic known to inhibit the release of dopamine via presynaptic mechanisms. In previous work the peripheral administration of CGS (1.25-20 mg/kg) produced place aversion at doses above 5 mg/kg. However, the contribution of peripheral mechanisms in the production of CGS-induced CPA is unknown. To test whether central administration of CGS would also result in CPA, rats were fitted with chronic intraventricular cannula. Groups of rats subsequently received four conditioning trials with one of four intraventricular (ICV) doses of CGS (1-30 micrograms) when confined to their preferred side of a place conditioning apparatus. Vehicle was similarly administered on four interspersed days prior to confining these same rats to their nonpreferred side of the apparatus. At the conclusion of these eight conditioning trials, the rats were tested, on separate days, in a nondrugged and a CGS-drugged state. The highest dose of CGS (30 micrograms) produced a CPA as evidenced by rats spending less time in the environment initially found to be preferred. Locomotor activity was also measured over a 30-min period with and without ICV injection of CGS (1-30 micrograms).(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90548-g" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90548-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Antipsychotic Agents/administration & dosage/*pharmacology
Avoidance Learning/*drug effects
Calcagnetti D J
Dopamine/*metabolism
Inbred Strains
Injections
Intraventricular
Male
Motor Activity/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Thiazepines/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(92)90114-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(92)90114-t</a>
Pages
969–976
Issue
6
Volume
16
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reducing the time needed to conduct conditioned place preference testing.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1905-06
Subject
The topic of the resource
Alkaloids/pharmacology; Animals; Choice Behavior/*drug effects; Conditioning; Experimental/instrumentation/methods; Inbred Strains; Male; Motor Activity/drug effects; Operant/*drug effects; Psychology; Psychotropic Drugs/pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the amphetamine-like stimulant drug cathinone (0.2 and 1.6 mg/kg) were selected to demonstrate the effectiveness of twice-a-day (morning-vehicle; afternoon-drug pairings) conditioning. The 0.2 mg/kg dose of cathinone failed to affect the expression of place preference, whereas the 1.6 mg/kg dose produced a significant (p less than 0.002) shift in CPP from baseline when compared to previous measurements. These results demonstrate that twice-a-day pairings over four days effectively shorten the total duration of training without changing the development of place preference produced by once-a-day over eight conditioning day schedule.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(92)90114-t" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(92)90114-t</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alkaloids/pharmacology
Animals
Calcagnetti D J
Choice Behavior/*drug effects
Conditioning
Experimental/instrumentation/methods
Inbred Strains
Male
Motor Activity/drug effects
Operant/*drug effects
Progress in neuro-psychopharmacology & biological psychiatry
Psychology
Psychotropic Drugs/pharmacology
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(92)90219-n" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(92)90219-n</a>
Pages
967–973
Issue
6
Volume
28
Dublin Core
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Title
A name given to the resource
Attenuation of drinking sweetened water following calcium channel blockade.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-06
Subject
The topic of the resource
Animals; Calcium Channel Blockers/*pharmacology; Cocaine/pharmacology; Dihydropyridines/pharmacology; Dose-Response Relationship; Drinking Behavior/*drug effects; Drug; Female; Inbred Strains; Injections; Intraventricular; Isradipine; Male; Rats; Reward; Taste/*drug effects
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
Recent reports cite results that both cocaine-induced conditioned place preference and activity stimulation are attenuated by pretreatment with the calcium channel blocker isradipine (ISR) in rats. By blocking voltage-dependent
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(92)90219-n" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(92)90219-n</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Brain research bulletin
Calcagnetti D J
Calcium Channel Blockers/*pharmacology
Cocaine/pharmacology
Dihydropyridines/pharmacology
Dose-Response Relationship
Drinking Behavior/*drug effects
Drug
Female
Inbred Strains
Injections
Intraventricular
Isradipine
Male
Rats
Reward
Schechter M D
Taste/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(93)90102-h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(93)90102-h</a>
Pages
695–700
Issue
5
Volume
30
Dublin Core
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Title
A name given to the resource
Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1905-06
Subject
The topic of the resource
Animals; Classical; Cocaine/*pharmacology; Conditioning; Extinction; Habituation; Inbred Strains; Male; Operant/*drug effects; Psychological/*drug effects; Psychophysiologic/drug effects; Rats; Reward
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This behavioral procedure is commonly known as the conditioned place preference (CPP)-test. At present, a firm theoretical understanding of the mechanisms underlying the production of a CPP are unknown. It is insufficient merely to know that a CPP can result after repeated drug pairings. Rather, it is necessary that the procedure is validated within a learning theory framework. The objective of the present study was, therefore, to establish that what is observed in place preference studies was, indeed, conditioning. This was accomplished by determining whether a cocaine-induced increase in time spent in a drug-paired environment was subject to attenuation following extinction trials. Rats were tested for their initial bias in spending more time in one of two stimulus-specific chambers of a place-conditioning apparatus. On four occasions, rats were injected with 2.5 mg/kg cocaine and confined to their less-preferred chamber whereas, on four alternating sessions, they were conditioned with saline (vehicle) in their preferred chamber. Subsequent testing in the nondrugged state revealed that these rats displayed a significant increase in the time spent in their initially least-preferred environment compared to baseline measurements. Following establishment of this cocaine-induced CPP, the rats were injected only with saline and conditioned for an equal number of sessions (i.e., four).(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(93)90102-h" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(93)90102-h</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Brain research bulletin
Calcagnetti D J
Classical
Cocaine/*pharmacology
Conditioning
Extinction
Habituation
Inbred Strains
Male
Operant/*drug effects
Psychological/*drug effects
Psychophysiologic/drug effects
Rats
Reward
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(94)90213-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(94)90213-5</a>
Pages
37–40
Issue
1
Volume
35
Dublin Core
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Title
A name given to the resource
Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994
Subject
The topic of the resource
*Fear; Animals; Classical/*drug effects; Conditioning; Electroshock; Female; Inbred Strains; Naltrexone/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
When a rat is returned to a context associated with mild electric foot shock (1 mA/0.75 s), the environmental cues elicit a species-specific defensive behavior termed freezing. Genetically divergent strains of rats given identical shock conditioning differ in the degree of freezing observed. The acquisition of freezing appears to be mediated, at least in part, by endogenous opioids since the duration that a rat spends freezing is increased by pretreatment prior to training with naltrexone (NTX), an opioid receptor antagonist. The objective of the present studies was to compare the shock-induced freezing and its enhancement with NTX in two unique strains of rats, viz., N/Nih and Fawn Hooded (FH), with that seen in the more commonly employed Sprague-Dawley strain (SPD). Age-matched female rats from these three strains were observed for freezing after shock conditioning. Separate groups of rats from each strain were treated with NTX (7.0 mg/kg) prior to shock. Vehicle (VEH; 0.9% saline)-treated SPD and N/Nih rats were observed freezing for approximately 30% of the testing duration, whereas FH rats froze for only 15% of the test duration. NTX-treated SPD and N/Nih rats displayed an equivalent 130% increase in freezing in comparison to their respective saline controls. Freezing in NTX treated FH rats did not differ from VEH. Collectively, these results suggest that the level of freezing and NTX enhancement of freezing in the N/Nih rat strain are equivalent to SPD. In comparison, FH rats show deficits in freezing and are insensitive to NTX enhancement of freezing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(94)90213-5" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(94)90213-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fear
1994
Animals
Brain research bulletin
Calcagnetti D J
Classical/*drug effects
Conditioning
Electroshock
Female
Inbred Strains
Naltrexone/*pharmacology
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/endo-128-1-131" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/endo-128-1-131</a>
Pages
131–138
Issue
1
Volume
128
Dublin Core
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Title
A name given to the resource
Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Animals; Brain/drug effects/*metabolism; Dose-Response Relationship; Drug; Estradiol/*pharmacology; Female; Inbred Strains; Organ Specificity; Ovariectomy; Pituitary Gland/drug effects/*metabolism; Prolactin/blood/*metabolism; Rats; Thyrotropin/blood/metabolism; Vasoactive Intestinal Peptide/*metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Doherty P C; Guan X B; Sturtevant J R; Walro D G
Description
An account of the resource
Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to determine the effects of this steroid on both pituitary VIP and PRL. To study this, pituitary VIP and PRL and plasma PRL were assayed in ovariectomized rats after treatment with estradiol benzoate (EB; 0.007, 0.07, 0.7, 7 or 70 microgram/rat). Pituitary and plasma TSH were also determined as well as VIP content in the medial basal hypothalamus, suprachiasmatic region, cerebral cortex, and jejunum. Oil-treated rats served as controls. Injection of 0.7 or 7 microgram EB resulted in a significant increase in pituitary PRL without changing plasma PRL levels or pituitary VIP content compared to values in the control group. Only treatment with 70 microgram EB produced a significant increase in both pituitary VIP and PRL as well as in plasma PRL compared to control values. EB treatment at any of the doses used had no significant effect on pituitary and plasma TSH or VIP content in any of the other tissues examined. These data show that pituitary PRL and VIP are differentially regulated in response to estrogen. The increases in pituitary VIP and basal plasma PRL after treatment with the highest dose of EB suggest that pituitary VIP may be involved in the development of estrogen-induced hyperprolactinemia. These data also show that the regulations of pituitary VIP and TSH are independent of each other in the estrogen-treated rat.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/endo-128-1-131" target="_blank" rel="noreferrer noopener">10.1210/endo-128-1-131</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Brain/drug effects/*metabolism
Carrillo A J
Doherty P C
Dose-Response Relationship
Drug
Endocrinology
Estradiol/*pharmacology
Female
Guan X B
Inbred Strains
Organ Specificity
Ovariectomy
Pituitary Gland/drug effects/*metabolism
Prolactin/blood/*metabolism
Rats
Sturtevant J R
Thyrotropin/blood/metabolism
Vasoactive Intestinal Peptide/*metabolism
Walro D G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/endo.131.2.1639033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/endo.131.2.1639033</a>
Pages
964–969
Issue
2
Volume
131
Dublin Core
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Title
A name given to the resource
Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary glands of intact male and female, ovariectomized, and estradiol benzoate-treated rats.
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-08
Subject
The topic of the resource
*Ovariectomy; Animals; Anterior/*chemistry/drug effects/metabolism; Diestrus; Estradiol/*pharmacology; Female; Immunohistochemistry; Inbred Strains; Male; Pituitary Gland; Prolactin/blood/metabolism; Rats; Vasoactive Intestinal Peptide/*analysis/metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Phelps C J
Description
An account of the resource
There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies have generally failed to detect VIP-immunoreactive (IR) cells in the pituitary of the untreated rat, although VIP-IR cells have been observed in the pituitaries of hypothyroid or estrogen-treated rats. This study was designed to examine the cellular distribution and tissue content of VIP in the anterior pituitary gland of rats under selected endocrine conditions known to alter the rates of PRL and VIP synthesis and secretion. To this end, anterior pituitary VIP and PRL content (ICC and RIA) and serum PRL levels were determined in ovariectomized (OVX) and OVX rats 3 days after treatment with 7 or 70 micrograms estradiol benzoate (EB). For comparison, pituitary VIP and PRL content (ICC and RIA) and serum PRL levels in untreated male and diestrous female rats were determined. Immunostaining for VIP was accomplished using a newly developed primary antiserum. Significant numbers of VIP-IR cells per 5-microns section were found in the anterior pituitary glands of all animals examined (275 +/- 33 in diestrous to 481 +/- 103 cells in male rats). VIP was not colocalized with PRL in any of the pituitaries regardless of steroid treatment or sex. Furthermore, the number of VIP-IR cells per pituitary gland was not significantly correlated with sex or EB treatment. Treatment with 70 micrograms, but not 7 micrograms, EB significantly increased the pituitary content of VIP and serum PRL levels compared to those after ovariectomy. However, both EB treatments resulted in a significant increase in pituitary PRL content compared to that in untreated OVX rats. Pituitaries from male rats had several-fold more VIP and less PRL content than pituitaries from diestrous rats. These data show that 1) in contrast to previous ICC studies, VIP-IR cells are readily detected in the anterior pituitary of intact male and female and OVX as well as EB-treated rats; 2) VIP is localized to cells other than lactotrophs, regardless of the steroid background; and 3) marked changes in anterior pituitary VIP content are not accompanied by changes in VIP-IR cell number.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/endo.131.2.1639033" target="_blank" rel="noreferrer noopener">10.1210/endo.131.2.1639033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ovariectomy
1992
Animals
Anterior/*chemistry/drug effects/metabolism
Carrillo A J
Diestrus
Endocrinology
Estradiol/*pharmacology
Female
Immunohistochemistry
Inbred Strains
Male
Phelps C J
Pituitary Gland
Prolactin/blood/metabolism
Rats
Vasoactive Intestinal Peptide/*analysis/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Pages
373–379
Issue
4
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.
Publisher
An entity responsible for making the resource available
Hippocampus
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-6
Subject
The topic of the resource
Animals; Calcium Channel Blockers/pharmacology; Dendrites/*physiology; Electric Stimulation; Enzyme Inhibitors/pharmacology; Genistein/pharmacology; Hippocampus/cytology/*physiology; In Vitro Techniques; Inbred Strains; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/*physiology; Phenols/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyramidal Cells/*physiology; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Cavus I; Teyler T J
Description
An account of the resource
The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in basal and apical dendrites was induced using stimulation pattern similar to the sharp wave-associated CA3 bursts. Basal dendritic non-NMDA LTP was input-specific and displayed similar development and magnitude to the apical dendritic non-NMDA LTP. Both apical and basal dendritic non-NMDA potentiations were inhibited by the voltage-dependent calcium channel (VDCC) inhibitor verapamil and the tyrosine kinase inhibitors genistein and levandustin A. However, the difference in the degree and time course of these inhibitions suggests involvement of distinct mechanisms in the two dendritic subfields.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Calcium Channel Blockers/pharmacology
Cavus I
Dendrites/*physiology
Electric Stimulation
Enzyme Inhibitors/pharmacology
Genistein/pharmacology
Hippocampus
Hippocampus/cytology/*physiology
In Vitro Techniques
Inbred Strains
Long-Term Potentiation/drug effects/*physiology
Male
N-Methyl-D-Aspartate/*physiology
Phenols/pharmacology
Protein-Tyrosine Kinases/antagonists & inhibitors
Pyramidal Cells/*physiology
Rats
Receptors
Teyler T J
Verapamil/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
3889–3897
Issue
7
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.
Publisher
An entity responsible for making the resource available
The Journal of biological chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-03
Subject
The topic of the resource
Animals; Rats; Organ Specificity; Kinetics; *Circadian Rhythm; Enzyme Induction; Liver/drug effects/*enzymology; Cholesterol 7-alpha-Hydroxylase/*biosynthesis/isolation & purification/metabolism; Cholestyramine Resin/*pharmacology; Chromatography; Durapatite; Hydroxyapatites; Isoenzymes/*biosynthesis/isolation & purification; Obesity/enzymology; Polyethylene Glycols; Steroid Hydroxylases/*biosynthesis; Inbred Strains; Zucker; Microsomes; Ion Exchange
Creator
An entity primarily responsible for making the resource
Chiang J Y; Miller W F; Lin G M
Description
An account of the resource
Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography. These two cytochrome P-450 isozymes were similar in electrophoretic mobility, immunocross-reactivity, and Vmax but differed in Km for cholesterol, turnover number, and charges. Antibody against the major isozyme was raised in rabbit. This antibody specifically inhibited microsomal cholesterol 7 alpha-hydroxylase activity. Immunoblot of microsomal polypeptides indicated that microsomal cholesterol 7 alpha-hydroxylase enzyme levels were increased in parallel with cholesterol 7 alpha-hydroxylase activity upon the treatment of rats with diet supplemented with cholestyramine. Both cholesterol 7 alpha-hydroxylase activity and enzyme levels were drastically reduced immediately after the removal of cholestyramine from the diet. Cholesterol 7 alpha-hydroxylase activity was also detected in the microsomes of kidney, heart, and lung in about 7-27% of the level found in the liver. 3-Methylcholanthrene treatment induced cholesterol 7 alpha-hydroxylase activity and enzyme level. In contrast, pregnenolone-16 alpha-carbonitrile or dexamethasone treatment greatly depressed enzyme and activity in rats. Cholesterol 7 alpha-hydroxylase enzyme level was 2-3-fold higher in liver microsomes of rats maintained under the reversed light cycle than under the normal light cycle. In genetically obese Zucker rats, cholesterol 7 alpha-hydroxylase activity and enzyme level did not respond to the change in the light cycle, however, were induced to the same levels as in the lean rats by cholestyramine treatment. This study provided the first direct evidence that the bile acid feedback regulation and circadian rhythm of microsomal cholesterol 7 alpha-hydroxylase activity involved the induction of cholesterol 7 alpha-hydroxylase enzyme level.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Circadian Rhythm
1990
Animals
Chiang J Y
Cholesterol 7-alpha-Hydroxylase/*biosynthesis/isolation & purification/metabolism
Cholestyramine Resin/*pharmacology
Chromatography
Department of Integrative Medical Sciences
Durapatite
Enzyme Induction
Hydroxyapatites
Inbred Strains
Ion Exchange
Isoenzymes/*biosynthesis/isolation & purification
Kinetics
Lin G M
Liver/drug effects/*enzymology
Microsomes
Miller W F
NEOMED College of Medicine
Obesity/enzymology
Organ Specificity
Polyethylene Glycols
Rats
Steroid Hydroxylases/*biosynthesis
The Journal of biological chemistry
Zucker
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90547-9</a>
Pages
497–501
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-11
Subject
The topic of the resource
Male; Animals; Rats; Analgesics/*pharmacology; Methysergide/pharmacology; Naltrexone/pharmacology; Amphetamines/*pharmacology; Pain/*metabolism; Morphine/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Serotonin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Boja J W; Schechter M D
Description
An account of the resource
The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not elevate tail-flick latency. In contrast, morphine (2-8 mg/kg, IP) produced analgesia on both the tail-flick and hot-plate tests in a dose-dependent manner. Neither the opiate antagonist naltrexone nor the adrenoceptor antagonist phentolamine effectively attenuated MDMA-induced analgesia. Conversely, the serotonin antagonist methysergide significantly reversed the analgesic effects of MDMA on the hot-plate test. These findings suggest that the antinociceptive effects of MDMA are serotonergically mediated. Furthermore, the results verify earlier findings describing the test-specific effects of serotonin-induced pain modulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90547-9</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Analgesics/*pharmacology
Animals
Boja J W
Crisp T
Dose-Response Relationship
Drug
Inbred Strains
Male
Methysergide/pharmacology
Morphine/pharmacology
N-Methyl-3
Naltrexone/pharmacology
Pain/*metabolism
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/drug effects/*physiology
Stafinsky J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
211–217
Issue
2
Volume
160
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Male; Animals; Rats; Adrenergic alpha-Antagonists/pharmacology; Injections; Serotonin Antagonists/pharmacology; Naltrexone/pharmacology; Spinal Cord/*drug effects; Biogenic Monoamines/*physiology; Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology; beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology; Norepinephrine/physiology; Serotonin/physiology; Inbred Strains; Spinal
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Hess J E; Uram M
Description
An account of the resource
beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the opioid interacts directly with spinal opiate receptors. Spinal administration of the alpha 1-adrenoceptor antagonist WB-4101 failed to alter the analgesic effects of the opioid, whereas the alpha 2-adrenoceptor antagonist yohimbine completely blocked beta-endorphin-induced elevations in tail-flick latency. Thus, there is an apparent specificity for the alpha
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Adrenergic alpha-Antagonists/pharmacology
Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology
Animals
beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology
Biogenic Monoamines/*physiology
Crisp T
European journal of pharmacology
Hess J E
Inbred Strains
Injections
Male
Naltrexone/pharmacology
Norepinephrine/physiology
Rats
Serotonin Antagonists/pharmacology
Serotonin/physiology
Spinal
Spinal Cord/*drug effects
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(91)90441-8</a>
Pages
247–251
Issue
2
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Pain Measurement; Piperazines/pharmacology; Spinal Cord/*physiology; Tetrahydronaphthalenes/pharmacology; Injections; Amphetamines/pharmacology; Biguanides/pharmacology; Serotonin Antagonists/pharmacology; Reaction Time/drug effects; *Analgesics; 8-Hydroxy-2-(di-n-propylamino)tetralin; Serotonin/*pharmacology; Inbred Strains; Receptors; Spinal; Serotonin/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B
Description
An account of the resource
1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(91)90441-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Analgesics
1991
8-Hydroxy-2-(di-n-propylamino)tetralin
Amphetamines/pharmacology
Animals
Biguanides/pharmacology
Crisp T
Donepudi H B
General pharmacology
Inbred Strains
Injections
Male
Pain Measurement
Perni V C
Piperazines/pharmacology
Rats
Reaction Time/drug effects
Receptors
Serotonin Antagonists/pharmacology
Serotonin/*drug effects/physiology
Serotonin/*pharmacology
Spanos L J
Spinal
Spinal Cord/*physiology
Stafinsky J L
Tetrahydronaphthalenes/pharmacology
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90133-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90133-m</a>
Pages
591–595
Issue
3
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonin contributes to the spinal antinociceptive effects of morphine.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-07
Subject
The topic of the resource
Adrenergic alpha-Antagonists/pharmacology; Adrenergic Antagonists; Analgesics/*pharmacology; Animals; Biogenic Monoamines/physiology; Dose-Response Relationship; Drug; Inbred Strains; Injections; Male; Morphine/*pharmacology; Naltrexone/pharmacology; Nerve Endings/drug effects; Opioid/drug effects; Rats; Reaction Time; Receptors; Serotonin Antagonists/pharmacology; Serotonin/*physiology; Spinal; Spinal Cord/*drug effects
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Uram M; Perni V C; Weaver M F; Spanos L J
Description
An account of the resource
This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats were fitted with IT catheters. One week later, animals were spinally pretreated with receptor antagonists selective for opioid, serotonin or alpha-adrenoceptors, and the ability of these agents to alter spinal morphine-induced antinociception was assessed. Morphine dose-dependently elevated tail-flick latency in a naltrexone-reversible manner. The serotonin receptor antagonists spiroxatrine (5-HT1A), pindolol (5-HT1B), ritanserin (5-HT2) and ICS
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90133-m" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90133-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Adrenergic alpha-Antagonists/pharmacology
Adrenergic Antagonists
Analgesics/*pharmacology
Animals
Biogenic Monoamines/physiology
Crisp T
Dose-Response Relationship
Drug
Inbred Strains
Injections
Male
Morphine/*pharmacology
Naltrexone/pharmacology
Nerve Endings/drug effects
Opioid/drug effects
Perni V C
Pharmacology, biochemistry, and behavior
Rats
Reaction Time
Receptors
Serotonin Antagonists/pharmacology
Serotonin/*physiology
Spanos L J
Spinal
Spinal Cord/*drug effects
Stafinsky J L
Uram M
Weaver M F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(92)91385-r" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(92)91385-r</a>
Pages
144–147
Issue
1
Volume
586
Dublin Core
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Title
A name given to the resource
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
*Sex Characteristics; 1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*pharmacology; Animals; Dopamine/metabolism; Drug Resistance/genetics; Inbred C57BL; Inbred Strains; Male; Mice; Norepinephrine/*metabolism; Olfactory Bulb/*metabolism; Osmolar Concentration
Creator
An entity primarily responsible for making the resource
Dluzen D E
Description
An account of the resource
Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within the OB were significantly decreased in MPTP-treated mice. These effects were more pronounced in the CD-1 (50% reduction) compared to the C57/Bl (20% reduction) strain. No effects of MPTP were observed on norepinephrine concentrations within the hypothalamus. Dopamine concentrations in the OB and hypothalamus did not differ between MPTP- and vehicle-treated mice in either strain. Overall, catecholamine concentrations within the OB, but not the hypothalamus, were significantly greater in C57/Bl compared to CD-1 mice. The reduction in OB norepinephrine concentration in the MPTP-treated animals may be related to the olfactory deficits which accompany Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(92)91385-r" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(92)91385-r</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1-Methyl-4-phenyl-1
1992
2
3
6-tetrahydropyridine/*pharmacology
Animals
Brain research
Dluzen D E
Dopamine/metabolism
Drug Resistance/genetics
Inbred C57BL
Inbred Strains
Male
Mice
Norepinephrine/*metabolism
Olfactory Bulb/*metabolism
Osmolar Concentration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66031222.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66031222.x</a>
Pages
1222–1226
Issue
3
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Norepinephrine is lateralized within the olfactory bulbs of male mice.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
*Functional Laterality; *Sex Characteristics; Animals; Dopamine/metabolism; Inbred Strains; Male; Mice; Norepinephrine/*metabolism; Olfactory Bulb/*metabolism; Osmolar Concentration; Potassium/pharmacology; Tissue Distribution
Creator
An entity primarily responsible for making the resource
Dluzen D E; Kreutzberg J D
Description
An account of the resource
Concentrations and in vitro release of norepinephrine were determined from left and right olfactory bulbs of adult male CD-1 mice. Norepinephrine concentrations from the left olfactory bulbs were significantly greater than those of the right (p \textless 0.01). No statistically significant differences were obtained for dopamine, nor were there differences in tissue weights between the left and right olfactory bulb tissue samples. To verify further this asymmetry, release rates of norepinephrine were measured from superfused left and right olfactory bulbs. Norepinephrine output from the left olfactory bulb was significantly greater than that from the right (p \textless 0.05). These results show that norepinephrine is lateralized within the olfactory bulbs of male mice. This asymmetry shows a clear catecholamine specificity with regard to concentrations and may be related to the lateralized olfactory processing that has been reported to occur in humans.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1996.66031222.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66031222.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Functional Laterality
*Sex Characteristics
1996
Animals
Dluzen D E
Dopamine/metabolism
Inbred Strains
Journal of neurochemistry
Kreutzberg J D
Male
Mice
Norepinephrine/*metabolism
Olfactory Bulb/*metabolism
Osmolar Concentration
Potassium/pharmacology
Tissue Distribution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1365-2826.2001.00675.x</a>
Pages
618–624
Issue
7
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice.
Publisher
An entity responsible for making the resource available
Journal of neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-07
Subject
The topic of the resource
Animals; Catecholamines/metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Estrogen Antagonists/*pharmacology; Female; Humans; Hypothalamus/metabolism; Inbred Strains; Male; Methamphetamine/*pharmacology; Mice; Neurotoxins/*pharmacology; Olfactory Bulb/metabolism; Organ Size/drug effects; Pituitary Gland/anatomy & histology; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Anderson L I
Description
An account of the resource
It has been demonstrated that the nigrostriatal dopaminergic system of male mice is more sensitive to the neurotoxic effects of methamphetamine (MA). The basis for this difference can be related to oestrogen, which has the capacity to function as a neuroprotectant against neurotoxins that target the nigrostriatal dopaminergic system. We examined the effects of the anti-oestrogen, tamoxifen (TMX), upon MA-induced neurotoxicity of the nigrostriatal dopaminergic system in intact female and male CD-1 mice. Striatal dopamine concentrations of TMX-treated female and male mice receiving MA were significantly greater than mice receiving MA alone. In female, but not male, mice, oestrogen treatment also resulted in greater striatal dopamine concentrations compared to mice receiving MA alone. Interestingly, male mice treated with oestrogen were particularly sensitive to the acute toxic effects of MA and displayed no evidence of nigrostriatal neuroprotection. The dihydroxyphenylacetic acid/dopamine ratios following MA for female and male mice treated with TMX or females treated with oestrogen were significantly reduced compared to MA-treated mice and oestrogen + MA-treated male mice. No differences among the treatment groups were obtained for dopamine in the hypothalamus or olfactory bulb. These data demonstrate that TMX treatment of intact female and male mice diminishes striatal dopamine depletions to the nigrostriatal dopaminergic neurotoxin, MA. Oestrogen also displayed this capacity when administered to female, but accentuated acute toxicity in male mice. These effects are relatively specific for the nigrostriatal dopaminergic system. Such data suggest that TMX can function as a nigrostriatal dopaminergic neuroprotectant against MA-induced neurotoxicity in intact female and male mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">10.1046/j.1365-2826.2001.00675.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Anderson L I
Animals
Catecholamines/metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Estrogen Antagonists/*pharmacology
Female
Humans
Hypothalamus/metabolism
Inbred Strains
Journal of neuroendocrinology
Male
McDermott J L
Methamphetamine/*pharmacology
Mice
Neurotoxins/*pharmacology
Olfactory Bulb/metabolism
Organ Size/drug effects
Pituitary Gland/anatomy & histology
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66020658.x</a>
Pages
658–666
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
*MPTP Poisoning; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; Inbred C57BL; Inbred Strains; Levodopa/pharmacology; Mice; Osmolar Concentration; Ovariectomy
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66020658.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
Inbred C57BL
Inbred Strains
Journal of neurochemistry
Levodopa/pharmacology
Liu B
McDermott J L
Mice
Osmolar Concentration
Ovariectomy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(92)91238-a" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(92)91238-a</a>
Pages
367–371
Issue
1
Volume
585
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
*Sex Characteristics; Animals; Catecholamines/*metabolism; Female; Hypothalamus; Inbred Strains; Male; Mice; Middle/*metabolism; Olfactory Bulb/*metabolism; Sexual Maturation/*physiology; Urine/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen D; Guan X; Vandenbergh J G
Description
An account of the resource
In the present experiment peri-pubertal female mice were treated with a partially purified puberty accelerating urine extract (PAUE). Mice treated with the PAUE showed an advance in the onset of puberty as indicated by significantly increased uterine weights. Treatment with the PAUE did not alter basal or potassium- (K+, 30 mM) stimulated release of catecholamines (dopamine or norepinephrine) from either anterior or posterior superfused olfactory bulb tissue fragments. There was, however, an overall significantly greater amount of basal and K(+)-stimulated release of NE from the posterior vs. the anterior olfactory bulb. Potassium-stimulated-, but not basal, release of catecholamines from the medial basal hypothalamus of PAUE-treated female mice were increased, with dopamine showing a statistically significant difference compared to water-treated females. These data demonstrate that treatment with the PAUE is a very effective means to accelerate the onset of puberty and results in accompanying increases in catecholaminergic activity, in particular dopamine, within the medial basal hypothalamus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(92)91238-a" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(92)91238-a</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1992
Animals
Brain research
Catecholamines/*metabolism
Dluzen D
Female
Guan X
Hypothalamus
Inbred Strains
Male
Mice
Middle/*metabolism
Olfactory Bulb/*metabolism
Sexual Maturation/*physiology
Urine/*physiology
Vandenbergh J G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
94–101
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulatory effects of testosterone on
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B
Description
An account of the resource
In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine/antagonists & inhibitors
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D
Dopamine/*metabolism
Drug Implants
Inbred C57BL
Inbred Strains
Jain R
Journal of neurochemistry
Levodopa/pharmacology
Liu B
Male
Mice
Neurotoxins/antagonists & inhibitors/*toxicity
Orchiectomy
Parkinson Disease
Reference Values
Secondary/chemically induced/*physiopathology
Species Specificity
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(91)90175-i</a>
Pages
273–276
Issue
2
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Inbred Strains; Levodopa/*administration & dosage/pharmacology; Male; Pulsatile Flow; Rats
Creator
An entity primarily responsible for making the resource
Dluzen D; McDermott J
Description
An account of the resource
In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue fragments of immature (25-32 day) and adult (90-120 day) male rats. In response to two pulse infusions of L-DOPA (5 microM) a significantly greater amount of dopamine and DOPAC was released from the striatal fragments of immature vs adult males. In contrast, when L-DOPA was infused continuously throughout the superfusion virtually identical amounts of dopamine and DOPAC were obtained for immature and adult male rats. No differences in postsuperfusion dopamine tissue content were obtained between adult and immature rats following the two pulses or continuous infusion of L-DOPA. These results suggest that the corpus striatum of the immature rat has an enhanced capacity to convert and release dopamine in response to a submaximal pulsatile infusion of L-DOPA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(91)90175-i</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*metabolism
Animals
Brain research. Developmental brain research
Corpus Striatum/*metabolism
Dluzen D
Dopamine/*metabolism
Inbred Strains
Levodopa/*administration & dosage/pharmacology
Male
McDermott J
Pulsatile Flow
Rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
267–273
Issue
2
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Female; Male; Animals; Mice; Sex Factors; Body Weight/drug effects; Organ Size/drug effects; Dopamine/*metabolism; Body Temperature/drug effects; Methamphetamine/*toxicity; Corpus Striatum/*metabolism; Orchiectomy; Ovariectomy; Drug Interactions; Estrogens/pharmacology/*physiology; Heart Rate/drug effects; Heart Ventricles/metabolism; Norepinephrine/metabolism; Pituitary Gland/anatomy & histology; Testosterone/pharmacology/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Anderson Linda I; Pilati Charles F
Description
An account of the resource
Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the cardiovascular and NSDA systems, suggest an important role for gonadal steroids in modulating toxicity to this psychostimulant. In the present report, we examined the effects of treatment with the gonadal steroid hormones E and testosterone (T) upon MA-induced toxicity within intact and castrated female and male CD-1 mice. Treatment of intact males with E produced a severe acute toxicity to MA, with only 41% (7/17) males surviving at 24-h post-MA. This incidence of mortality was significantly different from that of nonhormonally treated mice receiving an identical regimen of MA [94% survival (16/17)]. None of the other treatment groups showed mortality rates, which differed significantly from the nonhormonally treated mice. Striatal dopamine (DA) concentrations of E-treated female mice (intact or castrated) were significantly greater than that of the nonhormonally treated mice, which failed to differ statistically among each other. In an attempt to understand some of the bases for the mortality rates in
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Anderson Linda I
Animals
Body Temperature/drug effects
Body Weight/drug effects
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Drug Interactions
Estrogens/pharmacology/*physiology
Female
Heart Rate/drug effects
Heart Ventricles/metabolism
Inbred Strains
Male
Methamphetamine/*toxicity
Mice
Neurotoxicology and teratology
Norepinephrine/metabolism
Orchiectomy
Organ Size/drug effects
Ovariectomy
Pilati Charles F
Pituitary Gland/anatomy & histology
Sex Factors
Testosterone/pharmacology/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0169-328x(02)00520-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0169-328x(02)00520-x</a>
Pages
121–128
Issue
1
Volume
108
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.
Publisher
An entity responsible for making the resource available
Brain research. Molecular brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
*Membrane Glycoproteins; *Nerve Tissue Proteins; Animals; Delayed-Action Preparations; Dopamine Plasma Membrane Transport Proteins; Drug Combinations; Estrogen Antagonists/administration & dosage; Estrogens/administration & dosage/*pharmacology; Female; Inbred Strains; Membrane Transport Proteins/*genetics/metabolism; Messenger/*metabolism; Mice; Molecular Sequence Data; Norepinephrine Plasma Membrane Transport Proteins; Olfactory Bulb/*drug effects/enzymology/*physiology; Ovariectomy; Rats; RNA; Symporters/*genetics/metabolism; Tyrosine 3-Monooxygenase/*genetics/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Park June-Hee; Kim Kyungjin
Description
An account of the resource
Since estrogen exerts wide ranging effects within the central nervous system, it is important to investigate the sites and actions of this gonadal steroid hormone at extra-hypothalamic locations. In the present report, the effects of estrogen upon catecholaminergic function within the olfactory bulb were examined. To assess the role of estrogen at this site, ovariectomized mice received either no further hormonal treatment or were treated with estrogen, the anti-estrogen, tamoxifen, or a combination of estrogen and tamoxifen as administered in a 21-day release pellet. At 14 days post-hormonal treatment, the olfactory bulbs were assayed for mRNA levels of tyrosine hydroxylase, dopamine transporter and norepinephrine transporter using competitive-PCR. Tyrosine hydroxylase mRNA levels in either estrogen or estrogen+tamoxifen treated females were significantly decreased compared with non-hormonally treated controls. In addition, tyrosine hydroxylase mRNA levels of tamoxifen-treated mice were significantly greater than that of estrogen-treated mice. Dopamine transporter mRNA levels of tamoxifen-treated females were significantly greater than that of non-hormonally treated controls and estrogen treated mice. The combination of estrogen+tamoxifen significantly increased dopamine transporter mRNA levels compared to that of estrogen treated mice. No overall statistically significant differences in norepinephrine transporter mRNA levels were obtained among the four treatment groups. The data demonstrate that estrogen can exert significant modulatory effects upon olfactory bulb catecholaminergic function. Therefore, events which alter estrogen levels (menstrual/estrogen cycle, pregnancy/lactation, menopause, tamoxifen treatment) can modulate olfactory bulb catecholaminergic functions which may be involved with the detection and processing of olfactory stimuli.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0169-328x(02)00520-x" target="_blank" rel="noreferrer noopener">10.1016/s0169-328x(02)00520-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Membrane Glycoproteins
*Nerve Tissue Proteins
2002
Animals
Brain research. Molecular brain research
Delayed-Action Preparations
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins
Drug Combinations
Estrogen Antagonists/administration & dosage
Estrogens/administration & dosage/*pharmacology
Female
Inbred Strains
Kim Kyungjin
Membrane Transport Proteins/*genetics/metabolism
Messenger/*metabolism
Mice
Molecular Sequence Data
Norepinephrine Plasma Membrane Transport Proteins
Olfactory Bulb/*drug effects/enzymology/*physiology
Ovariectomy
Park June-Hee
Rats
RNA
Symporters/*genetics/metabolism
Tyrosine 3-Monooxygenase/*genetics/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000070278</a>
Pages
232–238
Issue
4
Volume
77
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Animals; Dopamine/metabolism; Female; Inbred Strains; Male; Messenger/drug effects; Methamphetamine/*toxicity; Mice; Neostriatum/*drug effects/metabolism; Neurodegenerative Diseases/*chemically induced/genetics; Neurotoxins/*toxicity; RNA; Sex Factors; Substantia Nigra/*drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Tweed Christopher; Anderson Linda I; Laping Nicholas J
Description
An account of the resource
In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury response associated with neurodegeneration. Striatal dopamine concentrations of MA-treated female mice were less depleted and significantly greater than that of identically treated males. Associated with this gender difference in striatal dopamine depletion were significantly decreased mRNA levels of plasminogen activator inhibitor-1 and a trend for increased (p = 0.06) mRNA levels of glial fibrillary acidic protein within females. No statistically significant differences between MA-treated female and male mice were obtained in mRNA levels for transforming growth factor-beta, transforming growth factor-beta type 2 receptor, activin-like kinase-5 or fibronectin. These data demonstrate the presence of changes in two specific molecular markers of the transforming growth factor-beta injury response which are in accordance with gender differences in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">10.1159/000070278</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Anderson Linda I
Animals
Dluzen Dean E
Dopamine/metabolism
Female
Inbred Strains
Laping Nicholas J
Male
Messenger/drug effects
Methamphetamine/*toxicity
Mice
Neostriatum/*drug effects/metabolism
Neurodegenerative Diseases/*chemically induced/genetics
Neuroendocrinology
Neurotoxins/*toxicity
RNA
Sex Factors
Substantia Nigra/*drug effects/metabolism
Tweed Christopher
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0024-3205(88)90267-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(88)90267-6</a>
Pages
913–922
Issue
11
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1905-06
Subject
The topic of the resource
Dialysis; Male; Animals; Rats; *Brain Chemistry; Chromatography; Electrochemistry; Corpus Striatum/analysis; Amino Acids/*analysis; Neurotransmitter Agents/*analysis; Inbred Strains; High Pressure Liquid/*methods
Creator
An entity primarily responsible for making the resource
Donzanti B A; Yamamoto B K
Description
An account of the resource
An improved, HPLC with electrochemical detection method for the isocratic separation and determination of amino acids from post-mortem brain tissue and from microdialysates of awake-behaving animals is described. Optimal conditions that maximize stability, resolution, and sensitivity were determined for the pre-column derivatization of amino acids using o-phthalaldehyde and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0024-3205(88)90267-6" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(88)90267-6</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Chemistry
1988
Amino Acids/*analysis
Animals
Chromatography
Corpus Striatum/analysis
Dialysis
Donzanti B A
Electrochemistry
High Pressure Liquid/*methods
Inbred Strains
Life sciences
Male
Neurotransmitter Agents/*analysis
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90102-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90102-5</a>
Pages
795–799
Issue
3
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A rapid and simple HPLC microassay for biogenic amines in discrete brain regions.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-07
Subject
The topic of the resource
Male; Animals; Rats; Reference Values; Organ Specificity; *Brain Chemistry; Chromatography; Biogenic Amines/*analysis; Corpus Striatum/analysis; Indicators and Reagents; Nucleus Accumbens/analysis; Inbred Strains; High Pressure Liquid/methods
Creator
An entity primarily responsible for making the resource
Donzanti B A; Yamamoto B K
Description
An account of the resource
A rapid microassay is described for the measurement of biogenic amines using an isocratic HPLC system with electrochemical detection. Catecholamines, indoleamines and their major metabolites were extracted with 150 microliters of perchloric acid from brain tissue punches (less than 250 micrograms) using a simple one-step sample preparation method. These compounds were separated on a short (80 mm) column with 3 microns particle size packing, and electrochemically detected within a total run time of less than 6 minutes. Detection limit sensitivity was approximately 2-5 pg. This method, detailed in an easy-to-follow description, reduces assay time, minimizes the possibility for errors, maximizes efficiency, and requires only standard HPLC equipment and supplies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90102-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90102-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Chemistry
1988
Animals
Biogenic Amines/*analysis
Chromatography
Corpus Striatum/analysis
Donzanti B A
High Pressure Liquid/methods
Inbred Strains
Indicators and Reagents
Male
Nucleus Accumbens/analysis
Organ Specificity
Pharmacology, biochemistry, and behavior
Rats
Reference Values
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(78)90070-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(78)90070-9</a>
Pages
425–430
Issue
5
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Development of potentiation in the dentate gyrus of rat: physiology and anatomy.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1978
1978-10
Subject
The topic of the resource
Female; Male; Animals; Rats; In Vitro Techniques; Hippocampus/anatomy & histology/growth & development/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Duffy C J; Teyler T J
Description
An account of the resource
The physiological development of potentiating processes in the rat dentate gyrus were compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell frequency potentiation, post-tetanic potentiation and long-term potentiation. Frequency potentiation and long-term potentiation exhibited a developmental progression between 7 and 210 days postnatal. Posttetanic potentiation remained constant across this period. The relation of these findings to synaptogenesis and dendritic spine formation are discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(78)90070-9" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(78)90070-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1978
Animals
Brain research bulletin
Duffy C J
Female
Hippocampus/anatomy & histology/growth & development/*physiology
In Vitro Techniques
Inbred Strains
Male
Rats
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(78)90097-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(78)90097-7</a>
Pages
305–310
Issue
4
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Development of habituation in the dentate gyrus of rat: physiology and anatomy.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1978
1978-08
Subject
The topic of the resource
Female; Male; Animals; Rats; Synapses/physiology; Hippocampus/anatomy & histology/physiology; Inbred Strains; Habituation; Psychophysiologic/*physiology
Creator
An entity primarily responsible for making the resource
Duffy C J; Teyler T J
Description
An account of the resource
The physiological development of monosynaptic response habituation in the rat dentate gyrus was compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell habituation to several frequencies and intensities of monosynaptic excitation. Except for the youngest group, the degree of habituation increased as a function of age, paralleling the morphological development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(78)90097-7" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(78)90097-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1978
Animals
Brain research bulletin
Duffy C J
Female
Habituation
Hippocampus/anatomy & histology/physiology
Inbred Strains
Male
Psychophysiologic/*physiology
Rats
Synapses/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0306-4522(01)00014-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0306-4522(01)00014-8</a>
Pages
385–394
Issue
2
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
1905-6
Subject
The topic of the resource
Animals; Corpus Striatum/chemistry/*drug effects/metabolism; Dopamine/analysis/*metabolism; Estrogen Antagonists/*pharmacology; Estrogens/blood/*pharmacology; Female; Inbred Strains; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Ovariectomy; Substantia Nigra/chemistry/*drug effects/metabolism; Sympathomimetics/*toxicity; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Gao X; Dluzen D E
Description
An account of the resource
The effects of 17beta-estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from estrogen treated mice were significantly greater than that from non-estrogen treated mice following methamphetamine. Dopamine concentrations from estrogen+tamoxifen+methamphetamine treated mice were decreased compared to estrogen+methamphetamine treated mice and not significantly different from those of tamoxifen+methamphetamine treated mice or mice receiving methamphetamine alone. These results suggest that estrogen is functioning as a neuroprotectant of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity and that this neuroprotective effect of estrogen is abolished in the presence of tamoxifen. In Experiment 2, estrogen administration after methamphetamine treatment did not produce any significant changes in dopamine concentrations compared with methamphetamine treatment alone. The data from Experiment 2 show that estrogen cannot reverse the methamphetamine-induced neurotoxicity upon the nigrostriatal dopaminergic system. Similar results were observed for the potassium-stimulated dopamine outputs from these treatment conditions as evaluated with in vitro superfusion, although a difference between the two measures for the estrogen+methamphetamine treated group was obtained in Experiment 1. These results have important implications for estrogen-tamoxifen interactions upon the nigrostriatal dopaminergic system and the gender differences which are observed in Parkinson's disease and animal models of nigrostriatal dopaminergic neurotoxicity as well as for the proposed use of tamoxifen in pre-menopausal women at risk for breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0306-4522(01)00014-8" target="_blank" rel="noreferrer noopener">10.1016/s0306-4522(01)00014-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Corpus Striatum/chemistry/*drug effects/metabolism
Dluzen D E
Dopamine/analysis/*metabolism
Estrogen Antagonists/*pharmacology
Estrogens/blood/*pharmacology
Female
Gao X
Inbred Strains
Methamphetamine/*toxicity
Mice
Neuroprotective Agents/pharmacology
Neuroscience
Ovariectomy
Substantia Nigra/chemistry/*drug effects/metabolism
Sympathomimetics/*toxicity
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Pages
235–241
Issue
2
Volume
481
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Caudate Nucleus/drug effects/*metabolism
Dopamine/*metabolism
Electrochemistry
Glynn G E
Homovanillic Acid/metabolism
Inbred Strains
Indoles/*pharmacology
Male
Mazindol/*pharmacology
Neurotransmitter Uptake Inhibitors/*pharmacology
Nomifensine/*pharmacology
Putamen/drug effects/*metabolism
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)91390-m</a>
Pages
147–151
Issue
1
Volume
568
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
*Orchiectomy; Animals; Inbred Strains; Kinetics; Male; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*physiology; Potassium/*pharmacology; Rats; Reference Values; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Guan X B; Dluzen D
Description
An account of the resource
In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. II). Both basal and potassium (K+ 30 mM)-stimulated release of NE was greater in posterior compared to anterior OB. All groups were responsive to the K+ stimuli showing increases in NE release. The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. No differences in K(+)-stimulated release were observed between castrated and castrated plus testosterone-treated groups. These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)91390-m" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)91390-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
1991
Animals
Brain research
Dluzen D
Guan X B
Inbred Strains
Kinetics
Male
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*physiology
Potassium/*pharmacology
Rats
Reference Values
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ab.2004.09.033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ab.2004.09.033</a>
Pages
22–34
Issue
1
Volume
337
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction.
Publisher
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Analytical biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
*Microdissection; Animals; Cell Separation/*methods; Chondrocytes/chemistry/cytology; Connective Tissue Cells/chemistry/*cytology; Gene Expression Profiling/*methods; Growth Plate/cytology; Inbred Strains; Lasers; Messenger/analysis/*isolation & purification; Methods; Mice; Newborn; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tibia/cytology
Creator
An entity primarily responsible for making the resource
Jacquet Robin; Hillyer Jennifer; Landis William J
Description
An account of the resource
Studies of gene expression from bone, cartilage, and other tissues are complicated by the fact that their RNA, collected and pooled for analysis, often represents a wide variety of composite cells distinct in individual phenotype, age, and state of maturation. Laser capture microdissection (LCM) is a technique that allows specific cells to be isolated according to their phenotype, condition, or other marker from within such heterogeneity. As a result, this approach can yield RNA that is particular to a subset of cells comprising the total cell population of the tissue. This study reports the application of LCM to the gene expression analysis of the cartilaginous epiphyseal growth plate of normal newborn mice. The methodology utilized for this purpose has been coupled with real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) to quantitate the expression of certain genes involved in growth plate development and calcification. In this paper, the approaches used for isolating and purifying RNA from phenotypically specific chondrocyte populations of the murine growth plate are detailed and illustrate and compare both qualitative and quantitative RT-PCR results. The technique will hopefully serve as a guide for the further analysis of this and other connective tissues by LCM and RT-PCR.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ab.2004.09.033" target="_blank" rel="noreferrer noopener">10.1016/j.ab.2004.09.033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Microdissection
2005
Analytical biochemistry
Animals
Cell Separation/*methods
Chondrocytes/chemistry/cytology
Connective Tissue Cells/chemistry/*cytology
Gene Expression Profiling/*methods
Growth Plate/cytology
Hillyer Jennifer
Inbred Strains
Jacquet Robin
Landis William J
Lasers
Messenger/analysis/*isolation & purification
Methods
Mice
Newborn
Reverse Transcriptase Polymerase Chain Reaction
RNA
Tibia/cytology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-2952(88)90620-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-2952(88)90620-x</a>
Pages
4375–4380
Issue
22
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of rat brain pyruvate dehydrogenase by thiamine analogs.
Publisher
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Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-11
Subject
The topic of the resource
Male; Animals; Rats; Kinetics; Brain/*enzymology; Cerebral Cortex/drug effects/enzymology; Hippocampus/drug effects/enzymology; Pyruvate Dehydrogenase Complex/*antagonists & inhibitors; Thiamine Pyrophosphate/analogs & derivatives/pharmacology; Thiamine/*analogs & derivatives/pharmacology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Kandiko C T; Smith D; Yamamoto B K
Description
An account of the resource
The effects of thiamine thiazolone (TT) and thiamine thiazolone pyrophosphate (TTPP) on the in vitro and in vivo inhibition of pyruvate dehydrogenase complex (PDHC) from rat cortex and hippocampus were characterized. TTPP decreased PDHC activity in vitro but had no effect in vivo following its direct chronic administration via osmotic mini-pumps into the brains of behaving rats. In contrast, TT had no direct effect in vitro following a differential centrifugation purification of the mitochondrial PDHC fraction, but decreased PDHC activity in vivo. Additional experiments demonstrated that the cytosolic fraction converted TT to TTPP which, in turn, inhibited PDHC in vitro. A mechanism is proposed to explain these effects that is consistent with a non-competitive inhibition of brain PDHC by TTPP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-2952(88)90620-x" target="_blank" rel="noreferrer noopener">10.1016/0006-2952(88)90620-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Biochemical pharmacology
Brain/*enzymology
Cerebral Cortex/drug effects/enzymology
Hippocampus/drug effects/enzymology
Inbred Strains
Kandiko C T
Kinetics
Male
Pyruvate Dehydrogenase Complex/*antagonists & inhibitors
Rats
Smith D
Thiamine Pyrophosphate/analogs & derivatives/pharmacology
Thiamine/*analogs & derivatives/pharmacology
Yamamoto B K