1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2012.03.013</a> Pages 806–808 Issue 8 Volume 60 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion. Publisher An entity responsible for making the resource available Neurochemistry international Date A point or period of time associated with an event in the lifecycle of the resource 2012 2012-06 Subject The topic of the resource Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Synergism; Inbred C57BL; Indoles/*pharmacology; Methamphetamine/*pharmacology; Mice Creator An entity primarily responsible for making the resource Geldenhuys Werner J; Darvesh Altaf S; Dluzen Dean E Description An account of the resource Dimebon is an anti-histamine with central nervous system activity. In this report the effects of dimebon as a neuroprotectant in animal models of Parkinson's disease were tested as assessed in methamphetamine- and MPTP-induced striatal dopaminergic toxicity. Dimebon (1mg/kg) administered at 30 min prior to methamphetamine (40mg/kg) significantly reduced the amount of striatal dopamine depletion in mice, without altering the initial methamphetamine-induced increase in body temperature. In contrast, dimebon at either 1 or 25mg/kg administered at 30 min prior to MPTP (35 mg/kg) was unable to prevent MPTP-induced striatal dopamine loss as determined at 7 days post-methamphetamine/MPTP. These data suggest that dimebon may be exerting a neurotoxin specific neuroprotective effect upon the striatal dopaminergic system and may serve as an important tool for discriminating the mechanistic basis of these two dopaminergic neurotoxins. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2012.03.013</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2012 Animals Corpus Striatum/*drug effects/metabolism Darvesh Altaf S Department of Pharmaceutical Sciences Dluzen Dean E Dopamine/*metabolism Drug Synergism Geldenhuys Werner J Inbred C57BL Indoles/*pharmacology Methamphetamine/*pharmacology Mice NEOMED College of Pharmacy Neurochemistry international Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a> Pages 235–241 Issue 2 Volume 481 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen. Publisher An entity responsible for making the resource available Brain research Date A point or period of time associated with an event in the lifecycle of the resource 1989 1989-03 Subject The topic of the resource Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism Creator An entity primarily responsible for making the resource Glynn G E; Yamamoto B K Description An account of the resource The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1989 3 4-Dihydroxyphenylacetic Acid/metabolism Animals Brain research Caudate Nucleus/drug effects/*metabolism Dopamine/*metabolism Electrochemistry Glynn G E Homovanillic Acid/metabolism Inbred Strains Indoles/*pharmacology Male Mazindol/*pharmacology Neurotransmitter Uptake Inhibitors/*pharmacology Nomifensine/*pharmacology Putamen/drug effects/*metabolism Rats Yamamoto B K