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Text
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<a href="http://doi.org/10.1523/jneurosci.15-06-04693.1995" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.15-06-04693.1995</a>
Pages
4693–4711
Issue
6
Volume
15
Dublin Core
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Title
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Inputs to combination-sensitive neurons in the medial geniculate body of the mustached bat: the missing fundamental.
Publisher
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
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1995
1995-06
Subject
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Animals; Chiroptera/*physiology; Axonal Transport; Acoustic Stimulation; Neurons/*physiology; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Echolocation; *Brain Mapping; Horseradish Peroxidase; Cholera Toxin; Geniculate Bodies/anatomy & histology/*physiology; Inferior Colliculi/anatomy & histology/*physiology; Lysine/analogs & derivatives; Wheat Germ Agglutinins
Creator
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Wenstrup J J; Grose C D
Description
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This study examined projections to combination-sensitive neurons in the medial geniculate body of the mustached bat. These specialized neurons respond to the combination of two temporally and spectrally distinct components of the bat's sonar pulse and echo, encoding target information. Combination-sensitive neurons respond to the bat's sonar fundamental, between 24-31 kHz, in conjunction with a higher harmonic signal. They are thought to be formed in the medial geniculate body (MGB) by convergent input from inferior colliculus representations of 24-31 kHz and higher frequencies. This study used anterograde and retrograde tract-tracing methods in conjunction with physiological recording to test this MGB convergence hypothesis. In anterograde tracing experiments, multiple deposits of two different tracers were placed in the central nucleus of the inferior colliculus (ICC), one tracer in the 24-31 kHz region and another in an ICC representation responding to a higher sonar harmonic. We found only limited overlap in the MGB labeling patterns of the two tracers, and little in many areas where combination-sensitive neurons are common. In retrograde tracing experiments, a single deposit of tracer was placed at a combination-sensitive recording site in the MGB. With the deposit mostly limited to combination-sensitive MGB areas, labeling in 24-31 kHz representations of the ICC was absent or minor. These results suggest that many combination-sensitive neurons in the MGB do not receive 24-31 kHz ICC input. The strongest inputs to combination-sensitive MGB regions originate in high-frequency representations of the ICC and combination-sensitive regions of auditory cortex. Additional projections arrive from the thalamic reticular nucleus, external nucleus of the inferior colliculus, and pericollicular tegmentum. Each projection may contribute to the 24-31 kHz sensitivity of combination-sensitive neurons in the medial geniculate body.
Identifier
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<a href="http://doi.org/10.1523/jneurosci.15-06-04693.1995" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.15-06-04693.1995</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Mapping
1995
Acoustic Stimulation
Animals
Axonal Transport
Chiroptera/*physiology
Cholera Toxin
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation
Geniculate Bodies/anatomy & histology/*physiology
Grose C D
Horseradish Peroxidase
Inferior Colliculi/anatomy & histology/*physiology
Lysine/analogs & derivatives
NEOMED College of Medicine
Neurons/*physiology
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup J J
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Wheat Germ Agglutinins