1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.bbadis.2017.11.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbadis.2017.11.004</a> Pages 432–443 Issue 2 Volume 1864 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration. Publisher An entity responsible for making the resource available Biochimica et biophysica acta. Molecular basis of disease Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-02 Subject The topic of the resource *Astrocyte; *DNA methylation; *Epigenesis; *Epigenetic; *Histone; *Neurodegeneration; *Neuroinflammation; Acetylation; Alzheimer Disease/genetics/pathology; Animals; Astrocytes/*cytology/immunology; Cell Differentiation; DNA Methylation; Genetic; Histones/metabolism; Humans; Inflammation/*pathology; Methylation; MicroRNAs/metabolism; Neurodegenerative Diseases/genetics/*pathology; Neuroglia/metabolism; Neurons/immunology; Parkinson Disease/genetics/pathology Creator An entity primarily responsible for making the resource Neal Matthew; Richardson Jason R Description An account of the resource Epigenetic mechanisms control various functions throughout the body, from cell fate determination in development to immune responses and inflammation. Neuroinflammation is one of the prime contributors to the initiation and progression of neurodegeneration in a variety of diseases, including Alzheimer's and Parkinson's diseases. Because astrocytes are the largest population of glial cells, they represent an important regulator of CNS function, both in health and disease. Only recently have studies begun to identify the epigenetic mechanisms regulating astrocyte responses in neurodegenerative diseases. These epigenetic mechanisms, along with the epigenetic marks involved in astrocyte development, could elucidate novel pathways to potentially modulate astrocyte-mediated neuroinflammation and neurotoxicity. This review examines the known epigenetic mechanisms involved in regulation of astrocyte function, from development to neurodegeneration, and links these mechanisms to potential astrocyte-specific roles in neurodegenerative disease with a focus on potential opportunities for therapeutic intervention. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.bbadis.2017.11.004" target="_blank" rel="noreferrer noopener">10.1016/j.bbadis.2017.11.004</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Astrocyte *DNA methylation *Epigenesis *Epigenetic *Histone *neurodegeneration *Neuroinflammation 2018 Acetylation Alzheimer Disease/genetics/pathology Animals Astrocytes/*cytology/immunology Biochimica et biophysica acta. Molecular basis of disease Cell Differentiation Department of Pharmaceutical Sciences DNA Methylation Genetic Histones/metabolism Humans Inflammation/*pathology Methylation MicroRNAs/metabolism Neal Matthew NEOMED College of Pharmacy Neurodegenerative Diseases/genetics/*pathology Neuroglia/metabolism Neurons/immunology Parkinson Disease/genetics/pathology Richardson Jason R