Browse Items · NEOMED Bibliography Database

ANTIGENIC-STIMULATION AND MULTIPLE-MYELOMA - A PROSPECTIVE-STUDY

Background. A causal relationship between antigenic conditions and multiple myeloma was suggested by case reports. Although controlled studies identified associations with individual conditions, they failed to give overall support to the hypothesis.…

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Immunofluorescence staining is a widely used and powerful tool for the visualization and colocalization of two or more proteins and/or cellular organelles. For colocalization studies in fixed cells, one target protein/organelle is immunostained and…

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Tags: 2020, Autophagy, CCCP, Chondrocytes, Confocal microscopy, IL-1β, immunofluorescence, Inflammation, Mitochondria, Mitochondrial dysfunction, mitophagy, MitoTracker Deep Red, Osteoarthritis, Oxidative Stress, Parkin, PINK1

Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.

The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including…

Bile acid receptors in non-alcoholic fatty liver disease.

Accumulating data have shown that bile acids are important cell signaling molecules, which may activate several signaling pathways to regulate biological processes. Bile acids are endogenous ligands for the farnesoid X receptor (FXR) and TGR5, a…

Black Currant Phytoconstituents Exert Chemoprevention Of Diethylnitrosamine-initiated Hepatocarcinogenesis By Suppression Of The Inflammatory Response

Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine…

Bone mineral density in adolescent urinary stone formers: is sex important?

Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This…

Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.

BACKGROUND/AIMS: Butein (2',3,4,4'-Tetrahydroxychalcone), a polyphenol produced by several plants including Butea monoserpma, has been reported to exert potent anti-inflammatory activity but the mechanism remains unknown. In the present work we…

Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1

CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model

The mouse model of collagen induced arthritis (CIA) effectively mimics human disease and thus is useful for testing and development of rheumatoid arthritis (RA) therapies. We developed a Ligand Epitope Antigen Presentation System (LEAPS) peptide…

Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis

The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic heavy alcohol exposure is known to increase the chances of…

Decreasing Cb1 Receptor Signaling In Kupffer Cells Improves Insulin Sensitivity In Obese Mice

Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in…

Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma

Background: Neuroinflammation-astrogliosis, microglial activation, and changes in cytokine signaling-is a prominent feature of neurodegenerative disorders. Glaucoma is a group of chronic neurodegenerative conditions that make up the leading cause of…

Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach.

Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic …

Effect Of Age On Transcranial Doppler Velocities In Patients With Aneurysmal Subarachnoid Hemorrhage

Effects Of Exercise On C-reactive Protein In Healthy Patients And In Patients With Heart Disease: A Meta-analysis

Decreases in circulating hsCRP have been associated with increased physical activity and exercise training, although the ability of exercise interventions to reduce hsCRP and which individuals benefit the most remains unclear. This meta-analysis…

Emergent high fatality lung disease in systemic juvenile arthritis

OBJECTIVE: To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). METHODS: In a multicentre retrospective study, 61 cases were investigated…

Tags: 2019, Abulaban Khalid, adult onset still's disease, Akron Children's Hospital, Annals of the rheumatic diseases, Balise Raymond, Baszis Kevin, Behrens Edward M, Bejerano Gill, Birgmeier Johannes, Birmingham James, Bouzoubaa Layla, Canna Scott, Casey Alicia, Chen Guangbo, Childhood Arthritis and Rheumatology Research Alliance Registry Investigators, Cidon Michal, Cron Randy Q, Davis Mark M, De Aliva, De Benedetti Fabrizio, Department of Pediatrics, Desai Tushar, Deterding Robin, Deutsch Gail H, DMARDs (biologic), Ferguson Ian, Fishman Martha P, Goodman Steven I, Graham T Brent, Grom Alexei A, Guillerman R Paul, Haines Kathleen, Hazen Melissa, Henderson Lauren A, Ho Assunta, Ibarra Maria, Inflammation, Inman Christi J, Jagadeesh Karthik, Jerath Rita, Journal Article, juvenile idiopathic arthritis, Khatri Purvesh, Khawaja Khulood, Kingsbury Daniel J, Klein-Gitelman Marisa, Lai Khanh, Lapidus Sivia, Leung Ann N, Lin Clara, Lin Jenny, Liptzin Deborah R, Lu Ying, Mellins Elizabeth D, Milojevic Diana, Mombourquette Joy, NEOMED College of Medicine, November 2019 Update, Onel Karen, Ozen Seza, Perez Maria, Phillippi Kathryn, Prahalad Sampath, Radhakrishna Suhas, Reinhardt Adam, Riskalla Mona, Rosenwasser Natalie, Roth Johannes, Saper Vivian E, Schneider Rayfel, Schonenberg-Meinema Dieneke, Schulert Grant, Shenoi Susan, Smith Judith A, Sönmez Hafize Emine, Stoll Matthew L, Tian Lu, Towe Christopher, Treatment, Vargas Sara O, Vehe Richard K, Xu Jianpeng, Yang Jacqueline, Young Lisa R

From mechanisms to management: translating the neuropathic pain consensus recommendations into clinical practice.

Chronic neuropathic pain poses a treatment challenge, and is associated with significant psychologic distress, physical disability, and impaired functioning, which impact the activities of daily living. Efforts to provide relief are often inadequate…

From mechanisms to management: translating the neuropathic pain consensus recommendations into clinical practice.

Chronic neuropathic pain poses a treatment challenge, and is associated with significant psychologic distress, physical disability, and impaired functioning, which impact the activities of daily living. Efforts to provide relief are often inadequate…

Tags: 2005, Adult, Aged, Analgesics, Analgesics – Administration and Dosage, Analgesics – Adverse Effects, Antidepressive Agents, Breast Neoplasms, Cancer Patients, Chevlen E, Chronic pain, Clinical Trials, Combination, Comorbidity, Continuing (Credit), Cytokines – Physiology, Davies PS, Department of Internal Medicine, Drug Therapy, Drugs, Education, Female, Gabapentin – Administration and Dosage, Inflammation, Journal of the American Academy of Nurse Practitioners, Lidocaine – Administration and Dosage, Lung Neoplasms, Melanoma, Middle Age, NEOMED College of Medicine, Neoplasm Metastasis, Neural Transmission – Physiology, Neuralgia – Classification, Neuralgia – Drug Therapy, Neuralgia – Physiopathology, Opioid – Administration and Dosage, Pain Measurement, Perception, Peripheral Nervous System – Physiopathology, Rectal Neoplasms, Rhiner M, Sarcoidosis, Tramadol – Administration and Dosage, Transdermal Patches, Treatment Duration, Treatment Outcomes, Tricyclic – Administration and Dosage, Visual Analog Scaling

Hepatic Neuregulin 4 Signaling Defines An Endocrine Checkpoint For Steatosis-to-nash Progression

Nonalcoholic steatohepatitis (NASH) is characterized by progressive liver injury, inflammation, and fibrosis; however, the mechanisms that govern the transition from hepatic steatosis, which is relatively benign, to NASH remain poorly defined.…

Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting

Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated…

Tags: 2020, Ahmad Nashrah, Ansari Mohammad Y, Bano Shabana, Department of Anatomy & Neurobiology, Haqqi Tariq M, Imperatorin, Inflammation, iNOS, International Immunopharmacology, journalArticle, June 2020 Update II, NEOMED College of Medicine, Osteoarthritis, Oxidative-stress, Plant-derived-polyphenol

In-hospital levels of C-reactive protein and IL-6 predict post-operative depressive symptoms among patients undergoing total knee replacement surgery

Behavioral changes observed following immune system activation are similar to many of the hallmark symptoms of major depressive disorder (MDD), including appetite change, lethargy, fatigue, negative mood and anhedonia. Acute phase proteins, such as…

Inhibition of Histone H3K27 Acetylation Orchestrates Interleukin-9-Mediated and Plays an Anti-Inflammatory Role in Cisplatin-Induced Acute Kidney Injury.

Nephrotoxicity is a major side effect of cisplatin (CP)- and platinum-related chemotherapy, and inflammation contributes to disease pathogenesis. Interleukin-9 (IL-9) is a pleiotropic cytokine associated with inflammation. Here, we investigated the…

Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

Macrophages play a crucial role in the pathogenesis of atherosclerosis, but the molecular mechanisms remain poorly understood. Here we show that microRNA-34a (miR-34a) is a key regulator of macrophage cholesterol efflux and reverse cholesterol…

Mechanical solution for a mechanical problem: Tennis elbow.

Lateral epicondylitis is a relatively common clinical problem, easily recognized on palpation of the lateral protuberance on the elbow. Despite the "itis" suffix, it is not an inflammatory process. Therapeutic approaches with topical non-steroidal…

Tags: 2013, Adaptive equipment, Elbow, Epicondylitis, Inflammation, Mechanical overload, Rothschild Bruce, Tennis elbow, World journal of orthopedics

Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies.

Alzheimer's disease (AD) is a prominent neurodegenerative disorder characterized by deposition of β-amyloid (Aβ)-containing extracellular plaques, accompanied by a microglial-mediated inflammatory response, that leads to cognitive decline. Microglia…

Tags: 2020, AD, barrier, Casali BT, CSF1R, Department of Pharmaceutical Sciences, Inflammation, journalArticle, July 2020 List, Landreth GE, MacPherson KP, Microglia, NEOMED College of Pharmacy, Neurobiology of disease, Neuroprotection, Plaques, Reed-Geaghan EG

MICROGLIAL ACTIVATION AND THE IMMUNOINFLAMMATORY RESPONSE AFTER A MODERATE TRAUMATIC BRAIN INJURY

Tags: 2016, activation, Crish S, Department of Pharmaceutical Sciences, General & Internal Medicine, Inflammation, Journal Article, Journal of neurotrauma, Mice, NEOMED College of Pharmacy, Neuron, Neurosciences & Neurology, Smith A

Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic…

Tags: 2021, Alzheimer’s disease, Alzheimer&#8217, Casali BT, Cells, Department of Pharmaceutical Sciences, Inflammation, journalArticle, May 2021 List, Microglia, NEOMED College of Pharmacy, NEOMED College of Pharmacy Postdoc, NEOMED Postdoc Publications, Neurodegenerative Diseases, Neuroinflammation, Reed-Geaghan EG, s disease, TREM2

Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic…

Tags: 2021, Alzheimer disease, Inflammation, Microglia, neurodegenerative disease, Neuroinflammation, TREM2

miR-467 regulates inflammation and blood insulin and glucose

Obesity is associated with inflammation and insulin resistance (IR), but the regulation of insulin sensitivity (IS) and connections between IS and inflammation remain unclear. We investigated the role of miR-467a-5p, a miRNA induced by…

Tags: Gajeton J, Inflammation, Insulin Resistance, Journal of Cellular and Molecular Medicine, journalArticle, Krukovets I, Macrophages, March 2021 List, microRNA/miR-467a-5p, NEOMED College of Medicine Student, NEOMED Student Publications, Stenina-Adognravi O, Sul L, Vasanji A, Verbovetskiy D, Yendamuri R

Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway.

Mitochondrial function is impaired in osteoarthritis (OA) but its impact on cartilage catabolism is not fully understood. Here, we investigated the molecular mechanism of mitochondrial dysfunction-induced activation of catabolic response in …

Tags: 2020, Ahmad N, Ansari M Y, cFos-AP1, Chondrocytes, Department of Anatomy & Neurobiology, Haqqi TM, Inflammation, JNK, Journal of Cell Science, journalArticle, NEOMED College of Medicine, NEOMED Student Publications, Novak K, October 2020 List, Osteoarthritis, Redox, Voleti S, Wase SJ

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.

Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high …

Tags: 2020, Ahmad N, Ansari MY, August 2020 List, Biomedicine & Pharmacotherapy, Chondrocytes, Department of Anatomy & Neurobiology, Haqqi TM, Inflammation, journalArticle, NEOMED College of Medicine, Nrf2, Osteoarthritis, Polyphenols, Redox

Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis

Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation. Due to dismal prognosis and limited therapeutic intervention, chemoprevention has emerged as…

Relationships between Very Low-Density Lipoproteins-Ceramides, -Diacylglycerols, and -Triacylglycerols in Insulin-Resistant Men.

This short report describes the relationships between concentrations of ceramides (CER), diacylglycerols (DAG), triacylglycerols (TAG) in very low-density lipoproteins (VLDL) particles, and hepatic lipid accumulation. VLDL particles were isolated…

Retinal ganglion cell loss and gliosis in the retinofugal projection following intravitreal exposure to amyloid-beta.

Pathological accumulations of amyloid-beta (Aβ) peptide are found in retina early in Alzheimer's disease, yet its effects on retinal neuronal structure remain unknown. To investigate this, we injected fibrillized Aβ(1-42) protein into the eye of…

Tags: 2020, Alzheimer's disease, amyloid-beta, CD36, Cluster of differentiation 36, Crish SD, Dengler-Crish C M, Glaucoma, Inflammation, journalArticle, NEOMED College of Graduate Studies Student, NEOMED Student Publications, Neurobiology of disease, October 2020 List, retina, Simons ES, Smith M A, superior colliculus

Role of Inflammation in Modulating Thrombotic-Fibrinolytic Balance in Venous Thrombosis.

Tags: *chemokines, *Editorials, *fibrinolytic therapy, *Inflammation, *T-lymphocytes, *Thrombosis, *venous thrombosis, 2016, Circulation research, Fibrinolytic Agents, Humans, Igwe Chinedu, Inflammation, Penn Marc S, Thrombolytic Therapy

Role of inflammation in the aging bones.

Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to inherent changes in mesenchymal stem cell (MSC) differentiation,…

Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.

Accumulating evidence suggests that inflammation has a key role in the pathogenesis of osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory mediators in OA and drives many pathological changes during the…

Tags: 2020, Ahmad Nashrah, Ansari Mohammad Y, Chondrocytes, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation, iNOS, iNOS inhibitor, Journal of cellular physiology, NEOMED College of Medicine, NITRIC oxide, Osteoarthritis, Oxidative Stress

Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.

Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule involved in various signaling pathways via its function as a PAP enzyme in the triglyceride synthesis pathway and in the nucleus as a transcriptional co-regulator.…

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