Browse Items · NEOMED Bibliography Database

Concurrent treatment of chronic psoriasis and asthma with ustekinumab.

A 56-year-old woman with a 40-year history of guttate flares of psoriasis associated with stress and infection as well as chronic asthma was treated with subcutaneous injections of ustekinumab, repeated after 1 month and then every 3 months. Her…

Predictors of epinephrine autoinjector needle length inadequacy.

BACKGROUND: Self-administered epinephrine is the primary out-of-hospital treatment of anaphylaxis. Intramuscular injection of epinephrine results in higher peak plasma concentration than subcutaneous injection. With the prevalence of obesity,…

Tags: *Needles, 2013, Adolescence, Adolescent, Adult, Anaphylaxis – Drug Therapy, Anaphylaxis/*drug therapy, Bhalla Mary Colleen, Body Mass Index, Cross Sectional Studies, Cross-Sectional Studies, Department of Emergency Medicine, Epinephrine – Administration and Dosage, Epinephrine/*administration & dosage, Equipment Design, Equipment Failure, Female, Frey Jennifer A, Gable Brad D, Human, Humans, Injections, Intramuscular – Equipment and Supplies, Intramuscular/instrumentation, Male, Middle Age, Middle Aged, Needles, NEOMED College of Medicine, Prospective Studies, Quadriceps Muscle/*anatomy & histology/diagnostic imaging, Quadriceps Muscles – Anatomy and Histology, Quadriceps Muscles – Ultrasonography, Reichenbach Matthew R, Sex Factors, Sympathomimetics – Administration and Dosage, Sympathomimetics/*administration & dosage, The American journal of emergency medicine, Ultrasonography, Wilber Scott T, Young Adult

Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.

BACKGROUND: We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. METHODS: IL-1beta was…

The treatment of palmar and plantar warts using natural alpha interferon and a needleless injector.

BACKGROUND: The treatment of palmar and plantar warts is difficult and often frustrating. The need for multiple destructive treatments and recurrences after apparent cure are common. OBJECTIVE: The purpose of this study was to determine if…

Tags: 1995, Adolescent, Adult, Bredle D L, Brodell R T, Child, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Female, Foot Dermatoses/*therapy, Hand Dermatoses/*therapy, Humans, Injections, Interferon-alpha/*administration & dosage/therapeutic use, Intralesional, Jet, Male, Middle Aged, Warts/*therapy

Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.

Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine…

Tags: 1991, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Avoidance Learning/*drug effects, Calcagnetti D J, Dopamine/*metabolism, Inbred Strains, Injections, Intraventricular, Male, Motor Activity/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/administration & dosage/*pharmacology

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism…

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Increases in the locomotor activity of rats after intracerebral administration of cathinone.

There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine…

Tags: 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Cerebral Ventricles/drug effects/*physiology, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Motor Activity/*drug effects, Nucleus Accumbens/drug effects/*physiology, Psychotropic Drugs/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley, Stereotaxic Techniques, Substantia Nigra/drug effects/*physiology

Attenuation of drinking sweetened water following calcium channel blockade.

Recent reports cite results that both cocaine-induced conditioned place preference and activity stimulation are attenuated by pretreatment with the calcium channel blocker isradipine (ISR) in rats. By blocking voltage-dependent

Calcium channel blockade attenuates angiotensin II-induced drinking in rats.

Lateral ventricular administration of angiotensin II (ANG II) produces potent dipsogenic effects in water-sated rats. ANG II seems to require functional voltage-gated calcium channels on neurons throughout circumventricular brain sites to exert its…

Tags: 1993, Amino Acid Sequence, Angiotensin II/*antagonists & inhibitors/pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Calcium Channel Blockers/administration & dosage/*pharmacology, Dimethyl Sulfoxide/pharmacology, Dose-Response Relationship, Drinking Behavior/*drug effects, Drug, Injections, Intraventricular, Isradipine/pharmacology, Male, Molecular Sequence Data, Rats, Schechter M D, Sprague-Dawley

A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.

In rats, restraint exposure potentiates the magnitude and duration of analgesia following both the peripheral and intracerebroventricular administration of several opioid agonists as compared to non-stressed controls. It has been suggested that the…

Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.

beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the…

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…

Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.

These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu…

The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.

1. Male Sprague-Dawley rats were fitted with intrathecal (i.t.) and intracerebroventricular (i.c.v.) catheters. Fentanyl was injected either i.t. or i.c.v., and the antinociceptive efficacy of fentanyl was evaluated using the tail-flick…

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in…

Serotonin contributes to the spinal antinociceptive effects of morphine.

This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats…

Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.

HDL and apolipoprotein A1 (apoA1) concentrations inversely correlate with risk of death from ischemic heart disease; however, the role of apoA1 in the myocardial response to ischemia has not been well defined. To test whether apoA1, the primary HDL…

Tags: *Disease Models, 2014, Animal, Animal Studies, Animals, Antioxidants – Administration and Dosage, Antioxidants – Metabolism, Antioxidants – Pharmacokinetics, Antioxidants – Therapeutic Use, Antioxidants/administration & dosage/*metabolism/pharmacokinetics/therapeutic use, Apolipoprotein A-I/blood/genetics/*metabolism, Apolipoproteins, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Biological, Cardiotonic Agents – Administration and Dosage, Cardiotonic Agents – Metabolism, Cardiotonic Agents – Pharmacokinetics, Cardiotonic Agents – Therapeutic Use, Cardiotonic Agents/administration & dosage/metabolism/pharmacokinetics/therapeutic use, Coenzyme Q, Coenzyme Q – Administration and Dosage, Coenzyme Q – Metabolism, Coenzyme Q – Pharmacokinetics, Coenzyme Q – Therapeutic Use, Dadabayev Alisher R, Dietary Supplements, Electron Transport – Drug Effects, Electron Transport Complex II/chemistry/metabolism, Electron Transport Complex III/chemistry/metabolism, Electron Transport/drug effects, Heart – Drug Effects, Heart/drug effects, Heart/drug effects/enzymology/*metabolism, Hypoalphalipoproteinemias/physiopathology, Inborn Errors – Physiopathology, Injections, Intestinal Absorption, Intraperitoneal, Knockout, Latchoumycandane Calivarathan, Lesnefsky Edward J, Lipid Metabolism, Male, McIntyre Thomas M, Mice, Mitochondria, Mitochondria – Drug Effects, Mitochondria – Metabolism, Models, Myocardial Infarction – Etiology, Myocardial Infarction – Metabolism, Myocardial Infarction – Pathology, Myocardial Infarction – Therapy, Myocardial Infarction/etiology/metabolism/pathology/*therapy, Myocardial Reperfusion Injury – Blood, Myocardial Reperfusion Injury – Metabolism, Myocardial Reperfusion Injury – Pathology, Myocardial Reperfusion Injury – Prevention and Control, Myocardial Reperfusion Injury/blood/metabolism/pathology/prevention & control, Myocardium, Myocardium – Metabolism, Myocardium – Pathology, Myocardium/enzymology/*metabolism/pathology, Penn Marc S, Proteins, Proteins – Metabolism, The Journal of nutrition, Tissue Distribution, Ubiquinone/administration & dosage/*analogs & derivatives/metabolism/pharmacokinetics/therapeutic use, Yin Guotian

Mesenchymal stem cells and their secretome partially restore nerve and urethral function in a dual muscle and nerve injury stress urinary incontinence model.

Childbirth injures muscles and nerves responsible for urinary continence. Mesenchymal stem cells (MSCs) or their secretome given systemically could provide therapeutic benefit for this complex multisite injury. We investigated whether MSCs or their…

Efficacy of intravenous lidocaine to reduce pain and distress associated with propofol infusion in pediatric patients during procedural sedation.

BACKGROUND: Research suggests that young children experience an increased incidence and severity of discomfort during propofol infusion. Evaluations of varied interventions to reduce or eliminate this discomfort with adult subjects suggest that…

The effects of intranasal infusion of

Male C57/B1 mice received bilateral intranasal infusions of saline, MPTP or an intraperitoneal injection of MPTP. Infusions were performed using a peristaltic pump at a setting of 100 microliters/min. The MPTP, diluted in saline at concentrations of…

Physical Compatibility Of 4% Sodium Citrate With Selected Antimicrobial Agents

A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia.

Five hundred ninety patients were enrolled in a prospective, multicenter, randomized trial comparing the efficacy and safety of 7 to 14 days of levofloxacin treatment with that of ceftriaxone and/or cefuroxime axetil in the management of…

Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery.

OBJECTIVE: Oral P2Y(1)(2) platelet receptor inhibitors are a cornerstone of reducing complications in patients with acute coronary syndromes or coronary stents. Guidelines advocate discontinuing treatment with P2Y(1)(2) platelet receptor inhibitors…

Tags: 2013, 80 and over, Adenosine Monophosphate/administration & dosage/*analogs & derivatives, Administration, Adult, Aged, Angiolillo Dominick J, Blood Transfusion/*statistics & numerical data, Brtko Miroslav, Cannon Louis A, Chandna Harish, Chronos Nicholas, Combination/statistics & numerical data, Coronary Artery Bypass/*statistics & numerical data, Dietrich Markus, Drug Therapy, Drug-Related Side Effects and Adverse Reactions/epidemiology, Dyke Cornelius M, Female, Firstenberg Michael S, Holmes David R, Humans, Hutyra Martin, Injections, Intravenous, Liu Tiepu, Male, Manoukian Steven V, Middle Aged, Montalescot Gilles, Oral, Placebo Effect, Platelet Aggregation Inhibitors/administration & dosage, Postoperative Hemorrhage/*epidemiology/*prevention & control, Prats Jayne, Premedication/*statistics & numerical data, Prevalence, Price Matthew, Purinergic P2Y Receptor Antagonists/administration & dosage, Pyridines/*administration & dosage, Ramaiahm Chandrashekar, Risk Assessment, The heart surgery forum, Todd Meredith, Topo Eric J, Treatment Outcome, Tummala Pradyumna, United States/epidemiology, Voeltz Michele, Welsby Ian

Cyclosporine disposition and long-term renal function in a 500-pound kidney transplant recipient.

Patient size has been suggested as a risk factor in kidney transplantation. We have followed a recipient of a cadaver kidney who became massively obese (232 kg, 511 lbs) 5 years posttransplantation. He has maintained stable renal function with no…

Local blistering reaction complicating subcutaneous injection of pegylated interferon in a patient with hepatitis C.

PEG-Intron is a covalent conjugate of recombinant alpha-2b interferon with monomethoxy polyethylene glycol (PEG). Compared to standard interferon-alpha injections, this preparation has a longer half-life allowing for once-weekly injections and…

Tags: *Interferon-alpha/*administration & dosage/*adverse effects, *Polyethylene Glycols, 2003, Blister/*chemically induced/pathology, Brodell Robert T, Gallina Kelly, Hepatitis C/*drug therapy, Humans, Injections, Interferon alpha-2, Journal of drugs in dermatology : JDD, Male, Middle Aged, Naffah Farid, Nedorost Susan, Recombinant Proteins, Subcutaneous

The effect of immediate intraperitoneal carboplatinum on wound healing.

The effect of introducing intraperitoneal carboplatinum on wound healing immediately after wound closure was studied using a rat model. All animals were opened through a midline incision. A bowel anastomosis was then performed in a single-or…

Tags: 1993, Animals, Carboplatin/*administration & dosage/pharmacology, Clark T, Dose-Response Relationship, Drug, Gynecologic oncology, Hopkins M P, Injections, Intraperitoneal, Jenison E L, Male, Postoperative Period, Rats, Shellhaas C, Sprague-Dawley, Stakleff K S, Tissue Adhesions/etiology, Wound Healing/*drug effects

The effect of various insufflation gases on tumor implantation in an animal model.

OBJECTIVE: The expanded use of laparoscopy has led to reports of tumor dissemination and spread to laparoscopic port sites. We previously showed that carbon dioxide insufflation produced tumor dissemination compared with laparotomy. It is unknown…

Early Uncomplicated Appendicitis-Who Can We Treat Nonoperatively?

This study evaluated nonoperative treatment for mild appendicitis and reviewed selection criteria to be used in introducing this option into clinical practice. A retrospective review of 73 consecutive cases of appendicitis treated by a single surgeon…

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.

Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human…

Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells.

The purpose of this study was to determine whether a combination of fibrin glue and cultured periosteal cells will result in new bone formation at heterotopic sites in nude mice. Growing cells and developing matrices surrounding periosteal explants…

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.

During heightened cardiac work, O2 consumption by the heart benefits energy production via mitochondria. However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. To understand the…

Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects

Plication augmentation of the modified Hummelsheim procedure for treatment of large-angle esotropia due to abducens nerve palsy and type 1 Duane syndrome.

BACKGROUND: Multiple procedures have been described to treat a large-angle esodeviation with an associated abduction deficit. We report a plication augmentation of the Hummelsheim procedure for the management of esotropia and severe abduction deficit…

Tags: *Ophthalmologic Surgical Procedures, 2015, 80 and over, Abducens Nerve Diseases/complications/physiopathology/*surgery, Adolescent, Adult, Aged, Binocular/physiology, Botulinum Toxins, Child, Cochran Megan, Duane Retraction Syndrome/complications/physiopathology/*surgery, El Sahn Mahmoud, Esotropia/etiology/physiopathology/*surgery, Eye Movements/physiology, Female, Granet David B, Hertle Richard W, Humans, Injections, Intramuscular, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Khayali Salma, Kinori Michael, Male, Middle Aged, Miller Kyle E, Neuromuscular Agents/administration & dosage, Oculomotor Muscles/drug effects/physiopathology/*surgery, Patil Preeti A, Preschool, Retrospective Studies, Robbins Shira L, Suture Techniques, Tendon Transfer, Type A/administration & dosage, Vision, Young Adult

Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.

Case reports of neurogenic pulmonary edema (NPE) often indicate that the edema resolves quickly. Because plasma epinephrine concentration may be elevated in NPE, and epinephrine has been shown to increase the rate of alveolar liquid clearance (ALC),…

Tags: 1998, Adrenal Glands/*metabolism, Adrenalectomy, Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use, Adrenergic beta-Antagonists/therapeutic use, American journal of respiratory and critical care medicine, Amiloride/therapeutic use, Animal, Animals, Awender N E, Blood, Blood Pressure, Brain Diseases/chemically induced/*complications, Central Nervous System Agents/adverse effects, Cisterna Magna, Disease Models, Diuretics/therapeutic use, Dogs, Epinephrine/blood/*physiology/therapeutic use, Extravascular Lung Water/chemistry/*metabolism, Female, Hypertension, Injections, Lane S M, Maender K C, Male, Maron M B, Propanolamines/therapeutic use, Proteins/analysis, Pulmonary Alveoli/*metabolism, Pulmonary Artery, Pulmonary Edema/etiology/*metabolism/prevention & control, Pulmonary/prevention & control, Sodium Channel Blockers, Veratrine/adverse effects

Effect of neuropeptide Y on hemodynamics of the rabbit lung.

We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg…

Tags: 1998, Animals, Cisterna Magna, Hemodynamics/*physiology, In Vitro Techniques, Injections, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maron M B, Neuropeptide Y/blood/pharmacology/*physiology, Norepinephrine/pharmacology, Perfusion, Pulmonary Circulation/drug effects/*physiology, Rabbits, Sympathetic Nervous System/drug effects/physiology, Vascular Resistance/drug effects/physiology, Vasoconstriction/drug effects/physiology, Vasoconstrictor Agents/pharmacology, Veratrine/administration & dosage/pharmacology

A subtherapeutic international normalized ratio despite increasing doses of warfarin: could this be malabsorption?

OBJECTIVE: To describe a case of warfarin resistance apparently caused by malabsorption and to review the literature regarding warfarin resistance. CASE SUMMARY: A 28-year-old renal transplant patient with systemic lupus erythematosus was admitted…

Comparison of short-acting intramuscular antipsychotic medication: impact on length of stay and cost.

A retrospective cohort study was conducted to determine if there is an association between short-acting intramuscular (SAIM) antipsychotics used for acute agitation and length of stay (LOS). Patients with a diagnosis of schizophrenia or…

Tags: 2011, Adult, American journal of therapeutics, Antianxiety Agents, Antiinfective Agents, Antipsychotic Agents – Administration and Dosage, Antipsychotic Agents – Economics, Antipsychotic Agents – Therapeutic Use, Benedetti AM, Benedetti Amanda M, Benzodiazepine – Economics, Benzodiazepine – Therapeutic Use, Department of Family & Community Medicine, Department of Internal Medicine, Female, Frazee L A, Frazee Lawrence A, Haloperidol – Economics, Haloperidol – Therapeutic Use, Health Care Costs, Heterocyclic Compounds – Economics, Heterocyclic Compounds – Therapeutic Use, Injections, Intramuscular, Length of Stay – Economics, Length of Stay – Statistics and Numerical Data, Leung JG, Leung Jonathan G, Male, Middle Age, Myers N, Myers Nancy, NEOMED College of Medicine, Prospective Studies, Psychomotor Agitation – Drug Therapy, Quinolone – Economics, Quinolone – Therapeutic Use, Retrospective Design, Schizophrenia – Drug Therapy, Thiazoles – Economics, Thiazoles – Therapeutic Use

Pseudogout following intraarticular injection of sodium hyaluronate.

Tags: 1998, Altawil B, Arthritis and rheumatism, Chondrocalcinosis/*chemically induced, Contraindications, Humans, Hyaluronic Acid/*adverse effects, Injections, Intra-Articular, Knee Joint/drug effects/physiopathology, Luzar M J, Male, Middle Aged, Osteoarthritis/*drug therapy, Pain/drug therapy

Verruca vulgaris. Treatment with natural interferon alfa using a needleless injector.

Tags: 1993, Adult, Archives of dermatology, Brodell R T, Child, Department of Family & Community Medicine, Female, Foot Diseases/therapy, Hand, Humans, Injections, Interferon-alpha/*administration & dosage, Intralesional, Jet, Naples S P, NEOMED College of Medicine, Warts/*therapy

Browse Items (54 total)