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Text
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URL Address
<a href="http://doi.org/10.1139/y02-121" target="_blank" rel="noreferrer noopener">http://doi.org/10.1139/y02-121</a>
Pages
935–940
Issue
10
Volume
80
Dublin Core
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Title
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Circadian variation in cell-adhesion molecule expression by normal human leukocytes.
Publisher
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Canadian journal of physiology and pharmacology
Date
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2002
2002-10
Subject
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*Circadian Rhythm; Adult; CD11a Antigen/metabolism; CD11b Antigen/metabolism; Cell Adhesion Molecules/*metabolism; Female; Flow Cytometry; Humans; Integrin alpha Chains/metabolism; Intercellular Adhesion Molecule-1/metabolism; L-Selectin/metabolism; Leukocytes/*metabolism; Lymphocytes/metabolism; Male; Middle Aged; Monocytes/metabolism; Neutrophils/metabolism
Creator
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Niehaus Gary D; Ervin Elyce; Patel Amit; Khanna Kamal; Vanek Vincent W; Fagan Diana L
Description
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Adhesion molecules located on the surface of blood-borne leukocytes permit adherence of leukocytes to the microvascular endothelium, diapedesis of leukocytes across vessel walls, formation of intimate multicell interactions, and enhanced transmembrane signal transduction. Since some leukocyte-mediated immune functions exhibit nocturnal intensification, the current study was conducted to investigate the hypothesis that expression of selected cell adhesion molecules (CAM) varies with circadian periodicity. Blood was collected from normal human donors over a 24-h period and CAM expression by monocytes, neutrophils, and lymphocytes evaluated by monoclonal antibody binding and flow cytometry. All leukocyte classes exhibited significant circadian-like variation (p \textless 0.05) in CD62L (L-selectin) expression. Similarly, a diurnal variation (p \textless 0.05) in monocyte and neutrophil CD54 (ICAM-1) was observed. Finally, neutrophils demonstrated a circadian-like variation (p \textless 0.05) in CD11a (LFA-1a). The rhythmic alterations in CAM expression may be clinically relevant, since changes in CAM expression have the potential to modulate the leukocyte-induced pathogenesis associated with disease progressions such as nocturnal asthma, the nighttime exacerbations of rheumatoid arthritis, and the high nocturnal incidence of cerebrovascular and cardiovascular crisis.
Identifier
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<a href="http://doi.org/10.1139/y02-121" target="_blank" rel="noreferrer noopener">10.1139/y02-121</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Circadian Rhythm
2002
Adult
Canadian journal of physiology and pharmacology
CD11a Antigen/metabolism
CD11b Antigen/metabolism
Cell Adhesion Molecules/*metabolism
Department of Integrative Medical Sciences
Department of Internal Medicine
Ervin Elyce
Fagan Diana L
Female
Flow Cytometry
Humans
Integrin alpha Chains/metabolism
Intercellular Adhesion Molecule-1/metabolism
Khanna Kamal
L-Selectin/metabolism
Leukocytes/*metabolism
Lymphocytes/metabolism
Male
Middle Aged
Monocytes/metabolism
NEOMED College of Medicine
Neutrophils/metabolism
Niehaus Gary D
Patel Amit
Vanek Vincent W