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Text
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URL Address
<a href="http://doi.org/10.1016/j.molimm.2005.12.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.molimm.2005.12.003</a>
Pages
1933–1940
Issue
12
Volume
43
Dublin Core
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Title
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Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.
Publisher
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Molecular immunology
Date
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2006
2006-05
Subject
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*Keratinocytes/metabolism/radiation effects; *Ultraviolet Rays; Cell Culture Techniques; Cells; Cultured; Epidermal Cells; Gene Expression Regulation/drug effects; Genetic/*radiation effects; Humans; Interleukin-12/*genetics/*metabolism/pharmacology; Transcription
Creator
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Molenda Matthew; Mukkamala Lakshmi; Blumenberg Miroslav
Description
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Interleukin-12 (IL-12) is a proinflammatory and immunomodulatory cytokine that plays a critical role it in innate and adaptive immunity by inducing production of interferon-gamma and other cytokines. IL-12 was shown to block the ultraviolet light-induced immunosuppression, important in cancer immunosurveillance, cutaneous allergies and inflammation. To characterize the molecular effects of
Identifier
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<a href="http://doi.org/10.1016/j.molimm.2005.12.003" target="_blank" rel="noreferrer noopener">10.1016/j.molimm.2005.12.003</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Keratinocytes/metabolism/radiation effects
*Ultraviolet Rays
2006
Blumenberg Miroslav
Cell Culture Techniques
Cells
Cultured
Epidermal Cells
Gene Expression Regulation/drug effects
Genetic/*radiation effects
Humans
Interleukin-12/*genetics/*metabolism/pharmacology
Molecular immunology
Molenda Matthew
Mukkamala Lakshmi
Transcription