Browse Items (3 total)
- Tags: Interleukin-6/genetics/*metabolism
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1beta-induced IL-6 expression in human OA chondrocytes.
Tags: *IL-6, *MCPIP1, *miRNA, *OSTEOARTHRITIS, *Vorinostat, 2017, Adult, Aged, CCAAT-Enhancer-Binding Proteins/genetics/metabolism, Cells, Chondrocytes/*metabolism/pathology, Connective tissue research, Cultured, Department of Anatomy & Neurobiology, Female, Gene Expression Regulation/*drug effects, Genetic, Haqqi Tariq M, Humans, Hydroxamic Acids/*pharmacology, Interleukin-1beta/genetics/*metabolism, Interleukin-6/genetics/*metabolism, Makki Mohammad S, Male, MicroRNAs/genetics/*metabolism, Middle Aged, NEOMED College of Medicine, Osteoarthritis/drug therapy/genetics/*metabolism/pathology, Promoter Regions, Ribonucleases/*biosynthesis/genetics, Transcription Factors/*biosynthesis/genetics, Vorinostat
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.
Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism