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40
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Text
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URL Address
<a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.intimp.2020.106612</a>
Pages
106612
Volume
85
ISSN
1878-1705 1567-5769
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.intimp.2020.106612</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Publisher
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International immunopharmacology
Date
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2020
2020-05-22
Subject
The topic of the resource
Imperatorin; inflammation; iNOS; Osteoarthritis; Oxidative-stress; Plant-derived-polyphenol
Creator
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Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M
Description
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Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by
Identifier
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<a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">10.1016/j.intimp.2020.106612</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Ahmad Nashrah
Ansari Mohammad Y
Bano Shabana
Department of Anatomy & Neurobiology
Haqqi Tariq M
Imperatorin
Inflammation
iNOS
International Immunopharmacology
journalArticle
June 2020 Update II
NEOMED College of Medicine
Osteoarthritis
Oxidative-stress
Plant-derived-polyphenol
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.intimp.2009.12.016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.intimp.2009.12.016</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
412-421
Issue
4
Volume
10
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Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model
Publisher
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International Immunopharmacology
Date
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2010
2010-04
Subject
The topic of the resource
acellular pertussis-vaccine; auto-immune; beta-chain; binding-site; Collagen induced arthritis; identification; immune responses; immunogenicity; Immunology; inflammation; peptide analog; Pharmacology & Pharmacy; Regulation of cytokines in autoimmunity; regulatory t-cells; rheumatoid-arthritis; Therapeutic vaccine; transgenic mice; Vaccines for autoimmunity
Creator
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Zimmerman D H; Taylor P; Bendele A; Carambula R; Duzant Y; Lowe V; O'Neill S P; Talor E; Rosenthal K S
Description
An account of the resource
The mouse model of collagen induced arthritis (CIA) effectively mimics human disease and thus is useful for testing and development of rheumatoid arthritis (RA) therapies. We developed a Ligand Epitope Antigen Presentation System (LEAPS) peptide hetero-conjugate vaccine containing an epitope of human collagen type II (CEL-2000) that acted as a therapeutic vaccine in the collagen induced arthritis (CIA) mouse model. LEAPS technology converts a small peptide containing a disease specific epitope into an immunogen by attaching it to an immune or T cell binding peptide (I/TCBL). For CEL-2000, a peptide from human collagen type II (254-273) is attached to the I/TCBL peptide from human in microglobulin (J). Treatment with CEL-2000 limited disease (CIA) progression, as demonstrated by reduced Arthritic Index (AI) score, and footpad swelling. Efficacy was confirmed by histopathological microscopic examination of tissues at the end of the study. CEL-2000 limited disease progression as well or better than the etanercept (Enbrel) therapeutic control with significantly better histopathological results than the etanercept treated mice. Most interestingly, CEL-2000 therapy modulated serum cytokine levels with an increase in IL-12p70 and IL-10, which are not seen with etanercept therapy, and reduced IL-17 and INF-alpha, also seen with etanercept, among other cytokines studied. CEL-2000 was safe and well tolerated for the mice that received 5 injections given every 2 weeks in a 90 day study supporting its potential usage for long term therapy. These studies demonstrate that fewer treatments with CEL-2000 provide therapy at least as effective as etanercept by specifically modulating the disease producing autoimmune response. (C) 2010 Elsevier B.V. All rights reserved.
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<a href="http://doi.org/10.1016/j.intimp.2009.12.016" target="_blank" rel="noreferrer noopener">10.1016/j.intimp.2009.12.016</a>
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Journal Article
2010
acellular pertussis-vaccine
auto-immune
Bendele A
beta-chain
binding-site
Carambula R
Collagen induced arthritis
Duzant Y
identification
immune responses
immunogenicity
Immunology
Inflammation
International Immunopharmacology
Journal Article
Lowe V
O'Neill S P
peptide analog
Pharmacology & Pharmacy
Regulation of cytokines in autoimmunity
regulatory t-cells
rheumatoid-arthritis
Rosenthal K S
Talor E
Taylor P
Therapeutic vaccine
Transgenic mice
Vaccines for autoimmunity
Zimmerman D H