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<a href="http://doi.org/10.1016/j.nano.2019.102107" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nano.2019.102107</a>
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Pages
102107
Volume
23
ISSN
1549-9642
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Title
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Nose-to-brain co-delivery of repurposed simvastatin and BDNF synergistically attenuates LPS-induced neuroinflammation
Publisher
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Nanomedicine: Nanotechnology, Biology, And Medicine
Date
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2019
2019-10-23
Subject
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Microglia; Nanoparticles; Drug repurposing; Polymersomes; Intranasal delivery
Creator
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Manickavasagam Dharani; Lin Li; Oyewumi Moses O
Description
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A therapeutic strategy that can combat the multifaceted nature of neuroinflammation pathology was investigated. Thus, we fabricated PEG-PdLLA polymersomes and evaluated the efficacy in co-delivery of simvastatin (Sim, as a repurposed anti-inflammatory agent) with brain derived neurotrophic factor (BDNF, as an exogeneous trophic factor supplementation). Using LPS model of neuroinflammation, intranasal administration of combination drug-loaded polymersomes (containing both Sim and BDNF; Sim-BDNF-Ps) markedly down-regulated brain levels of cytokines compared to free drug and single-drug-loaded polymersomes. Further, Sim-BDNF-Ps effectively replenished brain level of BDNF that was depleted following neuroinflammation, resulting in a 2-fold BDNF increase versus untreated LPS control group. We found out that the efficiency of the combination drug-loaded polymersomes to suppress microglia activation in brain regions followed the order: frontal cortex > striatum > hippocampus. Our findings indicated that Sim-BDNF-Ps could effectively inhibit microglial-mediated inflammation as well as potentially resolve the neurotoxic microenvironment that is often associated with neuroinflammation.
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<a href="http://doi.org/10.1016/j.nano.2019.102107" target="_blank" rel="noreferrer noopener">10.1016/j.nano.2019.102107</a>
PMID: 31655202
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Journal Article
2019
And Medicine
Biology
Department of Pharmaceutical Sciences
Drug repurposing
Intranasal delivery
Journal Article
Lin Li
Manickavasagam Dharani
Microglia
Nanomedicine: Nanotechnology
Nanomedicine: Nanotechnology, Biology, And Medicine
Nanoparticles
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
November 2019 Update
Oyewumi Moses O
polymersomes