Novel automated processing technique for standardization and normalization of fluorescein angiography images in patients with uveitis
Kesav Natasha Preethi; Yang Qixin; Losert Wolfgang; Sen H Nida
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2746415" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2746415</a>
Sight for Kids: Improving the Vision of Children in an At-Risk Population
Yusuf Saidah; Yalamanchili Siri; Parikh Ankur A; Erzurum Sergul
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2743996" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2743996</a>
Upregulation of monocarboxylate transporter 2 protects retinal ganglion cells in glaucoma
Pappenhagen Nate; Harun-Or-Rashid Mohammad; Jaboori Assraa Jassim; Inman Denise M
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2741271" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2741271</a>
Comparison of Patient Volumes between Academic and Private Practice Retinal Specialists
Sciulli Harrison; Miller Alexander G; Obri Mark; Miller Christian X; Hornik Joan H; Miller David G
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2744780" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2744780</a>
Neovascular Glaucoma Presenting Characteristics in a Referral-based Setting
Miller David G; Chandra Rohit; Fill Lauren; Miller Chase W; Gan Jenny; Giltner Angela; Pendergast Scott D
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2742253" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2742253</a>
Correlation of Medicare Patient Volume and Online Ratings for Retinal Physicians
Miller Christian X; Miller Alexander G; Obri Mark; Hornik Joan H; Rowland Douglas Y; Miller David G
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2744787" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2744787</a>
Impact of the Optiwave Refractive Analysis in Post-LASIK Patients Undergoing Cataract Surgery
Yalamanchili Siri; Parikh Ankur A; Gemmel David; Erzurum Sergul
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2742298" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2742298</a>
Glaucoma-associated E50K-optineurin mutation impairs mitochondrial-derived vesicle trafficking
Powers James; Trautman-Buckley Kayla; Sun Emily; Chen Charlaine; Inman Denise M; Tseng Henry
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2741309">https://iovs.arvojournals.org/article.aspx?articleid=2741309</a>
Dehydrated Extracellular Membranes in the Treatment of Severe Dry Eye
Parikh Ankur A; Yalamanchili Siri; Gemmel David; Erzurum Sergul
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2745672" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2745672</a>
Surgical Outcomes and Patient Satisfaction in Vitrectomy for Vitreous Floaters
Pophal Charles; Chandra Rohit; Hornik Joan H; Miller David G; Singerman Lawrence J; Zegarra Hernando; Novak Michael A; Pendergast Scott D; Coney Joseph M; Rao Llewelyn J; Zakov Z Nicholas; Schartman Jerome P
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2744965" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2744965</a>
Clinical and Electrophysiological Outcomes After Eye Muscle Surgery in 81 Adults with Infantile Nystagmus Syndrome (INS)
Hertle Richard W; Curtiss Molly; Ricker Isabel; Ghering Alyssa
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="http://doi.org/10.1016/j.jaapos.2019.08.111" target="_blank" rel="noreferrer noopener">10.1016/j.jaapos.2019.08.111</a>
Efficacy of Macular Hole Surgery in Patients with Idiopathic Macular Telangiectasia Type 2
Chandra Rohit; Pophal Charles; Miller Alexander G; Hornik Joan H; Schartman Jerome P; Coney Joseph M; Singerman Lawrence J; Miller David G
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2744960" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2744960</a>
Pre-degenerative Accumulation of Superoxide and Hydroxide in a Chronic Mouse Model of Glaucoma
Jassim Assraa Hassan; Inman Denise M
Investigative Ophthalmology & Visual Science
2019
2019-07
Journal Article
<a href="https://iovs.arvojournals.org/article.aspx?articleid=2741311" target="_blank" rel="noreferrer noopener">https://iovs.arvojournals.org/article.aspx?articleid=2741311</a>
Decreased Energy Capacity And Increased Autophagic Activity In Optic Nerve Axons With Defective Anterograde Transport
anterograde transport; autophagy; cholera; cholera-toxin; degeneration; dying back process; endoplasmic-reticulum; glaucoma; microscopy; Mitochondria; mitophagy; mouse model; Ophthalmology; optic neuropathy; stress; toxin-B
PURPOSE. Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally differentiated cells like neurons manage cytoskeletal and organelle turnover. How autophagy relates to associated neurodegenerative pathologies remain unclear. We examined autophagy in optic neuropathy by investigating cytoskeletal degradation, mitochondria, and autophagic vesicles in the DBA2/J mouse model of glaucoma exhibiting differing levels of axon transport functionality. METHODS. DBA/2J and DBA/2J(wt-gpnmb) control mice 11 to 14 months of age were injected with cholera toxin-B (CTB) to assay anterograde axonal transport. Axonal mitochondria and autophagic vesicles were analyzed with respect to transport integrity in proximal and distal optic nerve using serial block face scanning electron microscopy (3D EM). RESULTS. Several indices varied significantly between the DBA/2J and DBA/2Jwt-gpnmb mice, including mitochondrial volume, average number of autophagic vesicles per axon, and mitochondrial cristae. However, there were no differences in mitochondrial cristae for axons with functional versus dysfunctional CTB transport, suggesting that mitochondrial dysfunction precedes overt transport blockade. Anterograde transport failure was accompanied by a dissociation of the relationship between mitochondrial and axon volumes. Autophagic vesicle profiles were significantly increased in optic nerve with transport deficit, consistent with greater autophagic activity. Mitochondria within autophagosomes, indicative of mitophagy, were observed in both proximal and distal axons. CONCLUSIONS. Loss of anterograde transport in DBA/2J optic nerve is concomitant with diminished mitochondrial volume, increased cytoskeletal breakdown and autophagic activity, and accumulation of autophagic profiles, including signs of mitophagy, in proximal optic nerve. Axons with transport deficit are metabolically underserved, though not necessarily from mitophagy.
Kleesattel D; Crish S D; Inman D M
Investigative Ophthalmology & Visual Science
2015
2015-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1167/iovs.15-17885" target="_blank" rel="noreferrer noopener">10.1167/iovs.15-17885</a>
Source Of Optic Nerve Metabolic Vulnerability In Dba/2j Model Of Glaucoma
Ophthalmology
Inman D M; Palmer P G
Investigative Ophthalmology & Visual Science
2016
2016-09
Journal Article or Conference Abstract Publication
n/a
The Role Of Nrf2 Transcription Factor In Ganglion Cell Survival In Glaucoma
531 ganglion cells; 634 oxidation/oxidative or free radical damage; 740; Ophthalmology; transgenics/knock-outs
Inman D M; Coughlin L
Investigative Ophthalmology & Visual Science
2014
2014-04
Journal Article or Conference Abstract Publication
n/a
Clinical And Electrophysiological Results Of Eye Muscle Surgery In 17 Patients With Downbeat Nystagmus (dbn)
Ophthalmology
Hertle R W; Ahmad A
Investigative Ophthalmology & Visual Science
2017
2017-06
Journal Article or Conference Abstract Publication
n/a
Inhibition Of Apoptosis In Human Retinal Pigment Epithelial Cells Treated With Benzo(e)pyrene, A Toxic Component Of Cigarette Smoke
alzheimers-disease; dna-damage; experimental glaucoma; genistein; macular degeneration; memantine treatment; mitochondrial dysfunction; Ophthalmology; oxidative stress; protects; resveratrol
Mansoor S; Gupta N; Patil A J; Estrago-Franco M F; Ramirez C; Migon R; Sapkal A; Kuppermann B D; Kenney M C
Investigative Ophthalmology & Visual Science
2010
2010-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1167/iovs.09-4121" target="_blank" rel="noreferrer noopener">10.1167/iovs.09-4121</a>
Macular And Peripapillary Vascular Dropout Are Associated With Disease Severity In Advanced Glaucoma
Ophthalmology
Ghahari E; Zangwill L M; Bowd C; Hasenstab K; Hou H Y; Penteado R; Manalastas P I C; Moghimi S; Shoji T; Li A J; Nguyen K; Villatoro G; Yarmohammadi A; Weinreb R N
Investigative Ophthalmology & Visual Science
2018
2018-07
Journal Article or Conference Abstract Publication
n/a
3d-qsar And Docking Studies Of The Activin Receptor-like Kinase 5 Antagonists For Use In Glaucoma Filtration Surgery
computational modeling; cytokines/chemokines; Ophthalmology; wound healing
Geldenhuys W J; Sapitro J; Celmer M; Nakamura H
Investigative Ophthalmology & Visual Science
2010
2010-04
Journal Article or Conference Abstract Publication
n/a
Is 10 Years Of Age The End Of The Critical Period For Amblyopia Treatment?
Ophthalmology
Garuda S R; Magoon E H
Investigative Ophthalmology & Visual Science
1996
1996-02
Journal Article or Conference Abstract Publication
n/a
The Incidence Of Topographic Abnormalities In Patients Scheduled For Cataract Surgery
445 cataract; 574 keratoconus; 733 topography; Ophthalmology
Frank B; Trattler W; McCabe S; Correa R; Loh J; Buznego C
Investigative Ophthalmology & Visual Science
2014
2014-04
Journal Article or Conference Abstract Publication
n/a
Pulvinar-lp Cells Receiving Input From Superior Colliculus
Ophthalmology
Fish S E; Chalupa L M
Investigative Ophthalmology & Visual Science
1979
1979
Journal Article or Conference Abstract Publication
n/a
An Inventory Of Visually Guided Activities Self-reported By Individuals With Profound Visual Impairment
584 low vision; 754 visual acuity; 758 visual fields; Ophthalmology
Dagnelie G; Jeter P; Dalvin L; Arnold E
Investigative Ophthalmology & Visual Science
2013
2013-06
Journal Article or Conference Abstract Publication
n/a
Cytoskeletal Changes In The Visual Projection Of The Dba/2j Mouse
Ophthalmology
Crish S D; Lepp J K; Smith M A; Dengler-Crish C M; Wilson G N
Investigative Ophthalmology & Visual Science
2015
2015-06
Journal Article or Conference Abstract Publication
n/a
Thermoreversible Gel for Delivery of Activin Receptor-Like Kinase 5 Inhibitor in Glaucoma Filtration Surgery
receptors; Ophthalmology; wound healing; conjunctiva
Miladore N; Nakamura H; Geldenhuys W; Bhatia D; Sutariya V
Investigative Ophthalmology & Visual Science
2010
2010-04
Journal Article or Conference Abstract Publication
n/a
Does resveratrol exhibit antiviral properties against cytomegalovirus replication?
Ophthalmology
Atreides S A; Wilkins C; Ekworomadu C O; Docherty J J; Dix R D
Investigative Ophthalmology & Visual Science
2002
2002-05
Journal Article or Conference Abstract Publication
n/a
Value of Scheimpflug Photography in Predicting Corneal Decompensation Requiring Keratoplasty Following Cataract Surgery in Patients with Fuchs Dystrophy
Ophthalmology
Arshad J; Sankovic A; Sayegh R R
Investigative Ophthalmology & Visual Science
2018
2018-07
Journal Article or Conference Abstract Publication
n/a
Cytoskeletal and mitochondrial-related protein changes within the DBA/2J retinal projection
Ophthalmology
Wilson G N; Inman D M; Crish S D
Investigative Ophthalmology & Visual Science
2016
2016-09
Journal Article
n/a
Characterization of cytokine levels in the DBA/2J mouse model of glaucoma
Ophthalmology
Wilson G N; Smith M A; Dengler-Crish C; Inman D M; Crish S D
Investigative Ophthalmology & Visual Science
2015
2015-06
Journal Article
n/a
IMPACT OF PUPIL DILATION ON RETINAL MICROVASCULATURE IN HEALTHY EYES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
Ophthalmology
Villatoro G; Manalastas P I C; Hasenstab K; Nguyen K D; Bowd C; Hou H Y; Li A J; Penteado R; Moghimi S; Ghahari E; Weinreb R N; Zangwill L M
Investigative Ophthalmology & Visual Science
2018
2018-07
Journal Article
n/a
The Clinical Profile of Moderate Hyperopia in Children Three to Five Years of Age
Ophthalmology
Suh D W; Kulp M T; Dean T W; Kraker R T; Erzurum S A; Wallace D K; Pang Y; Shea C J; Avallone J M; Pediat Eye Dis Investigator Grp
Investigative Ophthalmology & Visual Science
2015
2015-06
Journal Article
n/a
Three-Dimensional Ultrastructure of Retinal Ganglion Cell Synapses in the DBA/2J Mouse Model of Glaucoma
Ophthalmology
Smith M A; Xia C Z; Fening K M; Nakamoto K T; Dengler-Crish C; Schofield B R; Crish S D
Investigative Ophthalmology & Visual Science
2015
2015-06
Journal Article
n/a
Synapse-like structures on retracting end-bulbs in the optic nerve of the DBA/2J mouse model of glaucoma
Ophthalmology
Smith M A; Inman D M; Dengler-Crish C M; Silver J; Crish S D
Investigative Ophthalmology & Visual Science
2016
2016-09
Journal Article
n/a
Node of Ranvier pathology in two mouse models of glaucoma
Ophthalmology
Smith M A; Plyler E; Dengler-Crish C M; Crish S D
Investigative Ophthalmology & Visual Science
2018
2018-07
Journal Article
n/a
Prevalence of CFH and ARMS2 Genetic Polymorphisms in African-American Patients with Age-Related Macular Degeneration
Ophthalmology
Shah A; Singerman L J; Zanke B
Investigative Ophthalmology & Visual Science
2015
2015-06
Journal Article
n/a
Suppression of Ocular Scarring After Glaucoma Filtration Surgery in Rabbits by Activin Receptor-Like Kinase 5 Inhibitor
growth factors/growth factor; inhibitory receptors; Ophthalmology; receptors; Wound healing
Sapitro J; Dunmire J J; Sutariya V; Geldenhuys W J; Hewit M; Yue Byjt; Nakamura H
Investigative Ophthalmology & Visual Science
2010
2010-04
Journal Article
n/a
Retinal amyloid pathology requires CD36 receptors
Ophthalmology
Plyler E; Smith M A; Richardson J R; Dengler-Crish C M; Crish S D
Investigative Ophthalmology & Visual Science
2018
2018-07
Journal Article
n/a
Evaluation of Visual Acuity and Acute Retinal Changes Following Intravitreal Injection of Ocriplasmin
Ophthalmology
Patel D; Shah A; Melchioris A; Miller D G
Investigative Ophthalmology & Visual Science
2017
2017-06
Journal Article
n/a
Resolution of Vitreomacular Traction Using Jetrea and its Potential Role in Diabetic Macular Edema
505 edema; 585 macula/fovea; 763 vitreous; Ophthalmology
Oneill B; Shah A; Coney J M
Investigative Ophthalmology & Visual Science
2014
2014-04
Journal Article
n/a