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Chapter 20 - Molecular insights into anatomy and physiology

Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved…

Tags: 2021, Balaena mysticetus, Blubber, bowhead whale, Cooper LN, Department of Anatomy & Neurobiology, DNA, Gorbunova V, January 2021 List, journalArticle, lipid, longevity, molecular evolution, NEOEMD College of Medicine, The Bowhead Whale

Chapter 21 - Age estimation

In the late 1980s, annual carbon isotope cycles in the baleen plates of bowhead whales formed the basis of the first effective means of estimating bowhead age. However, the baleen aging method could only be used for aging subadult whales less than…

Tags: 2021, Age estimation, aspartic acid racemization, bowhead, Department of Anatomy & Neurobiology, George JC, Givens GH, January 2021 List, journalArticle, Lubetkin SC, NEOMED College of Medicine, ovarian corpora counts, Stable isotopes, The Bowhead Whale, Thewissen JGM, tympanic bulla, Wetzel D, whaling artifacts, Zeh JE

Chapter 7 - Life history, growth, and form

Bering–Chukchi–Beaufort Sea bowhead whales are born at about 4.2m in length and 1000kg, in lead systems along the NW Alaskan coast. Bowheads in the other northern stocks are also born in ice-covered seas. Maximum body lengths (standard measure) can…

Tags: 2021, Balaena mysticetus, bowhead whale, Breed GA, Brower Jr HK, Department of Anatomy & Neurobiology, George JC, growth and form, January 2021 List, journalArticle, life history, longevity, NEOMED College of Medicine, Person BT, Sformo TL, Suydam RS, The Bowhead Whale, Thewissen JGM, Von Duyke A

Study design: A research primer for low- and middle-income countries

Study design is critical to ensure that research questions are answered in an appropriate and rational manner for all aspects of health, but particularly in emergency care. Appropriate study design selection is one of the most critical decisions to…

Tags: 2020, African Journal Of Emergency Medicine, Cleveland Clinic Akron General Hospital, Department of Emergency Medicine, Emergency Medicine, Graham CA, January 2021 List, journalArticle, Knott J, NEOMED College of Medicine, Research methods, Simon EL, Study Design

Chapter 9 - Anatomy of skull and mandible

The skull of the bowhead whale is composed of all the bones commonly found in mammals, although the shape of these bones is far from ordinary. Features related to feeding dominate the skull: there are no teeth, and the rostrum is long and curved,…

Tags: 2021, Balaena mysticetus, Bones, bowhead whale, Department of Anatomy & Neurobiology, George JC, Hillmann DJ, January 2021 List, journalArticle, Mandible, Nader PB, NEOMED College of Medicine, osteology, skull, Tarpley RJ, The Bowhead Whale, Thewissen JGM, whale

Promoting bone health in children and adolescents following solid organ transplantation.

Solid organ transplantation in children and adolescents provides many benefits through improving critical organ function, including better growth, development, cardiovascular status, and quality of life. Unfortunately, bone status may be adversely…

Getting accepted - successful writing for scientific publication: A research primer for low- and middle-income countries

Clear and precise writing is a vital skill for healthcare providers and those involved in global emergency care research. It allows one to publish in scientific literature and present oral and written summaries of their work. However, writing skills…

Tags: 2020, African Journal Of Emergency Medicine, Cleveland Clinic Akron General Hospital, Department of Emergency Medicine, Evidence-Based Medicine, January 2021 List, journalArticle, Kwan J, NEOMED College of Medicine, Osei-Ampofo M, Publishing, Scientific writing, Simon EL, Wachira BW

Chapter 13 - Female and male reproduction

An understanding of the functional morphology of the bowhead whale continues to have significance for population management. This chapter first examines the anatomical features of the bowhead whale reproductive system, with an emphasis on the female.…

Research skills and the data spreadsheet: a research primer for low- and middle-income countries

The specialty of Emergency Medicine continues to expand and mature worldwide. As a relatively new specialty, the body of research that underpins patient management in the emergency department (ED) setting needs to be expanded for optimum patient…

Tags: 2020, African Journal Of Emergency Medicine, Cleveland Clinic Akron General Hospital, Data, Department of Emergency Medicine, Hodkinson PW, January 2021 List, journalArticle, Khan AS, NEOMED College of Medicine, Research, Simon EL, Spreadsheet, Taylor DM

Chapter 33 - Commercial whaling

The commercial hunt of the four stocks of bowhead whales by the nations of Europe and North America commenced in 1540 and came to an effective end at the start of World War I. At that time, all four stocks had been driven to near extinction. Whalers…

Tags: 2021, Balaena mysticetus, Basques, bowhead whale, Britain, Department of Anatomy & Neurobiology, George JC, Germany, January 2021 List, journalArticle, NEOMED College of Medicine, The Bowhead Whale, The Netherlands, Thewissen JGM, United States, whaling, Yankee

Chapter 39 - Past, present, and future

We discuss the evolution, phylogenetic relations to right whales, and geographical distribution of bowhead whales. We summarize its relations to humans, including whaling by indigenous and European whalers, conservation efforts, and modern challenges…

Tags: 2021, Balaena mysticetus, bowhead whale, conservation, Department of Anatomy & Neurobiology, George JC, History, International Whaling Commission, Inupiat, January 2021 List, journalArticle, life history, NEOMED College of Medicine, prehistoric, The Bowhead Whale, Thewissen JGM, whaling

Chapter 18 - Sensory systems

The sensory biology of bowhead whales reflects features both related to their origin from land mammals and adaptations to their current environment, polar seas. There is anatomical and genomic evidence that bowheads have a sense of smell. Their sense…

Tags: 2021, audition, Balaena mysticetus, Balance, bowhead whale, Department of Anatomy & Neurobiology, George JC, gustation, January 2021 List, journalArticle, magnetosense, mechanosense, NEOMED College of Medicine, olfaction, Sformo TL, Suydam RS, The Bowhead Whale, Thewissen JGM, Vision

Chapter 8 - Prenatal development

The prenatal development of bowhead whales is poorly known, and no complete ontogenetic series exist. However, the available embryos and fetuses elucidate aspects of the development of the species, as well as that of all of mysticetes in general, and…

Tags: 2021, Balaena mysticetus, bowhead whale, Department of Anatomy & Neurobiology, Embryo, Fetus, George JC, gestation, heterochrony, Hillmann DJ, January 2021 List, journalArticle, NEOMED College of Medicine, Sheffield Gay, Stimmelmayr R, Suydam RS, Tarpley RJ, The Bowhead Whale, Thewissen JGM

Chapter 10 - Postcranial skeleton and musculature

The postcranial skeleton of bowhead whales was described in detail more than 100 years ago. The musculature of bowheads has not been studied in detail but matches that of other mysticetes in general features. In this chapter, we focus on some aspects…

Trends in demographics and markers of injury severity in traumatic cervical spinal cord injury.

Over the past four decades, there have been progressive changes in the epidemiology of traumatic spinal cord injury (tSCI). We assessed trends in demographic and injury-related variables in traumatic cervical spinal cord injury (tCSCI) patients …

Endothelial Trpv4 contributes to pressure overload-induced pathological hypertrophy via modulation of coronary angiogenesis

Tags: 2020, Adapala RK, angiogenesis, Cardiac hypertrophy, Chilian WM, Circulation research, Department of Integrative Medical Sciences, Fibrosis, Ion Channels, January 2021 List, journalArticle, Kanugula AK, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan VA, Paruchuri SM, Thodeti CK

First person - Mohammad Yunus Ansari

Tags: 2020, Ansari MY, Department of Anatomy & Neurobiology, January 2021 List, Journal of Cell Science, journalArticle, NEOMED College of Medicine

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Immunofluorescence staining is a widely used and powerful tool for the visualization and colocalization of two or more proteins and/or cellular organelles. For colocalization studies in fixed cells, one target protein/organelle is immunostained and…

Measuring acetyl-coa and acetylated histone turnover in vivo: Effect of a high fat diet.

Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for …

Calciphylaxis: The potential diagnostic role of radiologists.

Calciphylaxis is a deadly disease that is currently diagnosed through a skin biopsy of resultant necrotic lesions despite many cases lacking this characteristic finding. Recently, research has demonstrated the ability of various radiologic …

Tags: 2021, Abdominal pain, Acinetobacter baumannii, Burdorf BT, Calcific uremic arteriolopathy, Calciphylaxis, Calcium acetate, Cinacalcet, January 2021 List, journalArticle, Livedo reticularis, NEOMED College of Medicine Student, NEOMED Student Publications, Radiology, Radiology Case Reports, Splenic infarction

Analysing the literature: A research primer for low- and middle-income countries

Effective critical appraisal of medical research requires training and practice. Evidence-based medicine provides a framework for standardised review of manuscripts of nearly any research design. Online resources and communities exist to provide free…

Tags: 2020, African Journal Of Emergency Medicine, Carpenter CR, Cleveland Clinic Akron General Hospital, Department of Emergency Medicine, Evidence-Based Medicine, Graham CA, Hollong B, January 2021 List, journalArticle, Librarian search strategies, NEOMED College of Medicine, Patient safety/QI, Simon EL, Social Media

Early physiological and cellular indicators of cisplatin-induced ototoxicity.

Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted decrease in quality of life. Identification of early cisplatin-induced cochlear damage would greatly improve clinical diagnosis and provide potential drug …

Tags: 2021, Bao J, Bielefeld EC, Chen Y, cisplatin, Department of Anatomy & Neurobiology, Hair Cells, January 2021 List, Journal of the Association for Research in Otolaryngology : JARO, journalArticle, Mafi Amir M, Mellott JG, NEOMED College of Medicine, Ototoxicity, Schwann cell, Spiral ganglion neuron, Wang W, Yamoah EN

Intrinsic properties of avian interaural level difference sound localizing neurons.

Intrinsic properties of neurons are one major determinant for how neurons respond to their synaptic inputs and shape their outputs in neural circuits. Here, we studied the intrinsic properties of neurons in the chicken posterior portion of the…

Tags: 2021, action potential, Brain research, Curry RJ, Department of Anatomy & Neurobiology, interaural level difference, intrinsic property, January 2021 List, journalArticle, Lu Y, NEOMED College of Medicine, posterior portion of the dorsal nucleus of the lateral lemniscus

Full acceptance of bariatric surgery? ... Let's face reality and demand better evidence!

Tags: 2021, Bariatric Surgery, Bariatric Times, Carotid endarterectomy, Dan A, Department of General Surgery, EVIDENCE, Gastric Bypass, January 2021 List, journalArticle, MEDICAL personnel, NEOMED College of Medicine, Summa Health Akron City Hospital

Estimates of throughput and utilization at freestanding compared to low-volume hospital-based emergency departments.

OBJECTIVE: Our investigation compared throughput metrics and utilization measures for freestanding emergency departments (FSEDs) versus hospital-based emergency departments (HBEDs) of similar volumes in the United States. METHODS: This study is a…

Tags: 2020, Canellas M, Dark C, Department of Emergency Medicine, January 2021 List, Jouriles N, Journal Of The American College Of Emergency Physicians Open, journalArticle, Mangira C, NEOMED College of Medicine, Simon EL, Summa Health Akron City Hospital

Lipoxin A4 induces lipid class switching and inflammation resolution at the genomic level in human osteoarthritis

Tags: 2020, Amin A, Arthritis & Rheumatology, Chawla A, Dave M, Islam A, January 2021 List, journalArticle, NEOMED College of Medicine, NEOMED Student Publications, Parekh Akshat, Patel J

Funding sources for research: A research primer for low- and middle-income countries

Research is a fundamental component of the development of quality emergency care systems. Developing qualified professionals and programs to conduct emergency care research is essential to understanding epidemiology in low resource settings. This…

Tags: 2020, African Journal Of Emergency Medicine, Aluisio A, Cleveland Clinic Akron General Hospital, Department of Emergency Medicine, DeVos E, Emergency Medicine, January 2021 List, journalArticle, Low income countries, Mentorship, NEOMED College of Medicine, Research, Simon EL

The Case Files: A serious condition hiding behind nonspecific symptoms.

Mentorship and how to conduct research: A research primer for low- and middle-income countries

Development of a successful research program can seem daunting when looked at from the starting line. It will take years if not decades to succeed and become sustainable. It requires local partnerships and mentoring; it mandates the establishment of…

Tags: 2020, African Journal Of Emergency Medicine, Cleveland Clinic Akron General Hospital, Department of Emergency Medicine, Ducharme J, Emergency Medicine, January 2021 List, Jouriles N, journalArticle, Kole T, Low income countries, Maharjan RK, Mentorship, NEOMED College of Medicine, Research, Simon EL, Summa Health Akron City Hospital

Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease.

Scavenger receptor CD36 contributes significantly to lipid homeostasis, inflammation, and amyloid deposition, while CD36 deficiency is associated with restored cerebrovascular function in an Alzheimer's disease (AD) mouse model. Yet the…

Tags: 2020, Aging, Ahmed HS, Alzheimer's disease, Alzheimer&apos, Brain, CD36, cerebral amyloid angiopathy, Edler MK, January 2021 List, Johnson CT, journalArticle, mouse, NEOMED College of Medicine Student, NEOMED Student Publications, Richardson JR, s disease, The Journal of comparative neurology, vasculature

Acute kidney injury associated with urinary stone disease in children and young adults presenting to a pediatric emergency department.

Background: Acute kidney injury (AKI) due to urinary stone disease (USD) is rare in adults; AKI rates in children with USD may be higher, and emerging data links stones to chronic kidney disease (CKD) development in adults. Methods: This study is a …

TSP-1 (thrombospondin-1) deficiency protects APOE(-/-) mice against leptin-induced atherosclerosis.

OBJECTIVE: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on TSP-1 (thrombospondin-1) expression, a proatherogenic matricellular protein …

Carpal morphology and function in the earliest cetaceans

During the land-to-water transition in the Eocene epoch, the cetacean skeleton underwent modifications to accommodate life in the seas. These changes are well-documented in the fossil record. The forelimb transformed from a weight-bearing limb with…

Tags: 2021, ARTICLES, Cooper LN, Department of Anatomy & Neurobiology, Fish FE, Gavazzi LM, Hussain ST, January 2021 List, Journal of Vertebrate Paleontology, journalArticle, NEOMED College of Medicine, NEOMED Student Publications, Thewissen JGM

Bivariate markov model based analysis of ecg for accurate identification and classification of premature heartbeats and irregular beat-patterns

This paper describes a novel intelligent analysis technique based upon bivariate Markov model that integrates morphological and temporal features with a rule-based interval analysis of ECG signals to localize and accurately classify the premature…

Collaboration with non-emergency care specialists and other emergency care providers: A research primer for low- and middle-income countries

As emergency and acute care systems develop, the ability to broadly engage key stakeholders becomes paramount for success. Collaborating with emergency medicine clinicians as well as other providers who have already developed their specialties,…

Tags: 2020, African Journal Of Emergency Medicine, Best practice consensus, Cleveland Clinic Akron General Hospital, collaboration, Department of Emergency Medicine, emergency medicine research, Gutierrez CE, January 2021 List, journalArticle, NEOMED College of Medicine, Research networks, Simon EL, Systems development

Chapter 34 - Indigenous knowledge in research and management

Indigenous whalers know a great deal about the habits and environment of bowhead whales. That knowledge is essential for safe and effective hunting and has also been invaluable to scientific research and management of bowheads. Studies in Chukotka,…

Tags: 2021, bowhead whale, Department of Anatomy & Neurobiology, Ferguson SH, George JC, Huntington HP, Indigenous knowledge, January 2021 List, journalArticle, NEOMED College of Medicine, Noongwook G, Quakenbush L, scientific research, The Bowhead Whale, Thewissen JGM, wildlife management

A novel regulatory role of TRAPPC9 in osteoarthritis

Tags: 2020, Department of Anatomy & Neurobiology, Hussein N, January 2021 List, Journal of Bone and Mineral Research, journalArticle, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED Student Publications, Safadi F

Necrotizing soft tissue infection of the breast during COVID-19 pandemic.

Necrotizing soft tissue infection has been historically recognized as a severe, rapidly spreading soft tissue infection associated with a very high risk of mortality. Cases of primary necrotizing fasciitis of the breast are rarely described but…

Tags: 2020, ABDOMINAL wall, breast, Case reports in surgery, COVID-19 pandemic, DeVito R, January 2021 List, journalArticle, Kamagate N, Necrotizing fasciitis, NEOMED College of Medicine Student, NEOMED Student Publications, soft tissue infections, tobacco use

Conference presentations: A research primer for low- and middle-income countries

Presenting research at a conference is an opportunity to disseminate the findings, network with other researchers, and to develop your academic track record. Although every conference will have some local differences, there are common approaches to…

Tags: 2020, African Journal Of Emergency Medicine, Cleveland Clinic Akron General Hospital, Conference presentation, Conference proceedings, Department of Emergency Medicine, January 2021 List, journalArticle, Knott JC, NEOMED College of Medicine, Research methods, Simon EL, Taylor DM

Group II metabotropic glutamate receptors modulate sound evoked and spontaneous activity in the mouse inferior colliculus.

Little is known about the functions of group II metabotropic glutamate receptors (mGluRs2/3) in the inferior colliculus (IC)-a midbrain structure that is a major integration region of the central auditory system. We investigated how these receptors…

Tags: 2020, Auditory, Beebe NL, Department of Anatomy & Neurobiology, eNeuro, GABAergic, Galazyuk AV, January 2021 List, journalArticle, Kristaponyte I, LY354740, mGluR2/3, NEOMED College of Medicine, NEOMED Student Publications, neuromodulation, non-GABAergic, Schofield BR, Shanbhag SJ, Young JW

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